CAS: 26544-34-3; 7-(((2S,3R,4S,5S,6R)-3-(((2S,3R,4R)-3,4-Dihydroxy-4-(Hydroxymethyl)Tetrahydrofuran-2-yl)Oxy)-4,5-Dihydroxy-6-(Hydroxymethyl)Tetrahydro-2H-Pyran-2-yl)Oxy)-5-Hydroxy-2-(4-Hydroxyphenyl)-4H-Chromen-4-One

上下游产品

CAS号2280-44-6 D-glucopyranose | CAS号520-36-5 芹菜素; 芹黄素; 5,7,4... | CAS号578-74-5 芹甙元-7-葡萄糖苷

芹甙元-7-葡萄糖苷,Uridin-5'-(α-D-Apio-D-Furanosylpyrophosphat)置于sodium Chloride体系中,用 Aq. Buffer 用作溶剂,化学反应 2.0H,反应生成芹菜甙
参考文献:Udp-Apiose的实用制备及其在研究apiosyltransferase中的应用.
标题:Udp-Apiose的实用制备及其在研究apiosyltransferase中的应用.
摘要:Udp-Apiose(apiosyltransferase的供体底物)由于其分子内自环化能力而不稳定,导致形成apiofuranosyl-1,2-环磷酸酯的形成.因此,Udp-Apiose的稳定化对于其可用性以及鉴定和表征参与apiosylated糖链和糖苷的生物合成的apiosyltransferase必不可少.在这里,我们建立了一种使用大体积阳离子作为抗衡离子来稳定udp-Apiose的方法.大体积阳离子(如三乙胺)可有效抑制溶液中udp-Apiose的降解.使用三乙胺作为抗衡阳离子,在ph 6.0和25oc的条件下,Udp-Apiose的半衰期延长至48.1+/-2.4 H.Udp-Apiose与抗衡阳离子配合使用,可以在冰冻条件下长期存储.Udp-Apiose被用作芹菜素7-O-β-D-葡糖苷apiosyltransferase的供体底物以产生apiosylated糖苷apiin.该a
Doi:10.1016/j.Carres.2019.03.011

专利信息

专利号:US-2002165207-A1
优先权日:2001-05-02
标题 :Compositions and methods for the treatment of diabetic neuropathy
发明人：ROSENBLOOM RICHARD
摘要:Compositions and a method for the treatment of diabetic neuropathy is disclosed. The compositions comprise a mixture of a compound that promotes synthesis of nerve growth factor, an aldose reductase inhibitor and an antioxidant, optionally formulated in a pharmaceutically acceptable carrier. This combination of active agents provides significant, effective relief of the symptoms of diabetic neuropathy, as well as at least partial recovery of lost neurological function in some cases. In addition, the compositions of the present invention, when used in effective amounts to treat diabetic neuropathy, do not exhibit the severe side effects of many prior art compositions proposed for treatment of this ailment. n In a second aspect, a method for the administration of a composition in accordance with the present invention for the treatment of diabetic neuropathy is disclosed. In the method, an effective amount of the composition of the invention is administered on a regular basis over a period of time sufficient to provide the beneficial effects of relief from the symptoms of diabetic neuropathy, as well as at least some recovery of the damaged nerve tissues.

专利号:US-7914823-B2
优先权日:2000-12-21
标题 :Method and composition for the topical treatment of diabetic neuropathy
发明人：ROSENBLOOM RICHARD ALLEN
权利人:PROPHASE LABS INC
摘要:A method and composition for the treatment of diabetic neuropathy is disclosed. The composition comprises a cold compounded mixture of a compound that promotes synthesis of nerve growth factor, an aldose reductase inhibitor and an antioxidant formulated in a pharmaceutically acceptable carrier. It has been found that this combination of active agents provides significant, effective relief of the symptoms of diabetic neuropathy, as well as at least partial recovery of lost neurological function in some cases. In view of the consensus in the art that effective combinations of various active agents have not been demonstrated to be effective for the treatment of diabetic neuropathy, the present invention provides a surprising and unexpected effect. In addition, the topical compositions of the present invention, when used in effective amounts to treat diabetic neuropathy, do not exhibit the severe side effects of many prior art compositions proposed for treatment of this ailment. n In a second aspect, a method for the topical administration of a composition in accordance with the present invention for the treatment of diabetic neuropathy is disclosed. In the method, an effective amount of the composition of the invention is topically administered to the areas of the body that have been adversely affected by the diabetic neuropathy on a regular basis over a period of time sufficient to provide the beneficial effects of relief from the symptoms and at least some recovery of the damaged nerve tissues.

专利号:US-2007232495-A1
优先权日:2006-03-24
标题:Compositions and methods to add value to plant products, increasing the commercial quality, resistance to external factors and polyphenol content thereof
发明人：NAPPA ALVARO O; LORENZINI FELIPE C; SANHUEZA ANDRES L
权利人:NAPPA ALVARO O; LORENZINI FELIPE C; SANHUEZA ANDRES L
摘要:The invention is related to compositions and methods that naturally protect plant tissues against ultraviolet radiation and temperature, thus giving protection against sunburn to plants, plant parts, fruits and/or flowers during their development. The invention is also related to compositions and methods to naturally improve the color of plants, plant parts, fruits and/or flowers by inducing the natural synthesis of flavonoids and anthocyanins present in plants. Likewise, the present invention is directed to improving the nutritional value of plants, plant parts, fruits and/or flowers by increasing the normal levels of polyphenolic compounds, especially flavonoids, present therein. Additionally, the present invention is related to compositions and methods that give more resistance to plants, plant parts, fruits and/or flowers against pathogens as bacteria and fungi. Finally, the present invention is related to plants, plant parts, fruits, flowers and/or propagating material treated with the compositions described in the present document.