CAS: 3715-29-5; Sodium 3-Methyl-2-Oxobutanoate

相似化合物

3715-31-9 113-24-6 1173018-24-0

上下游产品

CAS号20201-24-5 3-甲基-2-氧代丁酰乙酯 | CAS号1068-55-9 异丙基氯化镁 | CAS号95-92-1 草酸二乙酯 | CAS号3952-67-8 2-氧代-3-甲基丁酸甲酯 | CAS号59935-29-4 L-缬氨酸-15N | CAS号72-18-4 l-缬氨酸 | CAS号640-68-6 D-缬氨酸 | CAS号759-05-7 3-甲基-2-氧丁酸 | CAS号13031-04-4 二氢-4,4-二甲基-2,3-呋喃二酮 | CAS号79-50-5 DL-泛酰内酯 | CAS号76585-78-9 benzyl 3-methyl... | CAS号77257-02-4 D-[2-2H]valine | CAS号77257-03-5 L-缬氨酸-D1

3-甲基-2-氧代丁酰乙酯 在 Lithium Hydroxide,水体系中,用 四氢呋喃作为反应溶剂,获得 Sodium 3-Methyl-2-Oxobutyrate
参考文献:[En] Process For Making N-Sulfonated-Amino Acid Derivatives[Fr] Procede De Fabrication De Derives D'Acides Amines N-Sulfones
标题:[En] Process For Making N-Sulfonated-Amino Acid Derivatives[Fr] Procede De Fabrication De Derives D'Acides Amines N-Sulfones

专利信息

专利号:US-5686275-A
优先权日:1991-12-23
标 题 :Synthesis of homochiral 2-hydroxy acids
发明人：CASEY GUY; LEE THOMAS; LEE ADMINISTRATOR VICTOR; LEE ADMINISTRATRIX EILEEN ANN
权利人:GENZYME LTD
摘要:PCT No. PCT/GB92/02396 Sec. 371 Date Aug. 26, 1994 Sec. 102(e) Date Aug. 26, 1994 PCT Filed Dec. 23, 1992 PCT Pub. No. WO93/13215 PCT Pub. Date Jul. 8, 1993A process for the production of a homochiral 2-hydroxy carboxylic acid or salt thereof corresponding to general formula (I), wherein R represents one of formulae (II), (III), (IV), (V), wherein R' represents straight- or branched-chain alkyl or phenyl optionally para-substituted with methyl, methoxy, nitro or amino; and R'' represents hydrogen, halogen or phenyl optionally para-substituted with methyl, methoxy, nitro or amino; and M represents hydrogen or a salt-forming moiety; characterized in that it comprises reducing a corresponding 2-keto carboxylic acid or salt thereof using a (R)- or (S)-2-oxo carboxylic acid dehydrogenase, inter alia, is disclosed.

专利号:WO-9313215-A1
优先权日:1991-12-23
标 题:Synthesis of homochiral 2-hydroxy acids

专利号:US-7122578-B2
优先权日:2001-09-11
标 题:Method and composition for treating mammalian diseases and injuries which cause pain, erythema, swelling, crusting, ischemia scarring and excess white blood cell infiltration
发明人：MARTIN ALAIN
权利人:MARTIN ALAIN
摘要:A method for treating the disease state in mammals caused by mammalian cells involved in the inflammatory response is disclosed. Mammalian cells participating in the inflammatory response are contacted with an inflammatory suppressor selected from the group consisting of alpha-keto acids and their salts which reduce the undesired inflammatory response and is an antioxidant. The inflammatory suppressor may further provide a cellular energy source and be a building block in the cellular synthesis of other cellular components. Compositions for reducing and treating undesired inflammatory response such as pain, swelling, erythema, crusting, scarring, itching, also disclosed.

专利号:EP-0620857-B1
优先权日:1991-12-23
标题:Synthesis of homochiral 2-hydroxy acids

专利号:EP-0620857-A1
优先权日:1991-12-23
标 题 :Synthesis of homochiral 2-hydroxy acids

专利号:US-9861636-B2
优先权日:2014-04-29
标题 :Polyfluorinated compounds acting as bruton tyrosine kinase inhibitors
发明人：HE WEI
权利人:HE WEI; ZHEJIANG DTRM BIOPHARMA CO LTD
摘要:Described herein is a novel series of multi-fluoro-substituted pyrazolopyrimidine compounds or salts thereof. These compounds are Bruton's tyrosine kinase (BTK) inhibitors. These compounds may possess better BTK inhibition selectivity and pharmacokinetic properties. Disclosed herein are the synthesis methods of these compounds. Disclosed herein are novel synthesis methods of the multi-fluoro-substituted benzophenone and substituted phenoxy benzene. Also disclosed are pharmaceutical compositions comprising the BTK inhibitors described herein. The present invention also relates to pharmaceutical formulations comprising the compounds described herein as active ingredients. The present invention also includes the therapeutic methods by administering the BTK inhibitors and their formulations to treat and inhibit autoimmune disease, hypersensitivity disease, inflammatory diseases and cancer.