专利号:US-2002161219-A1 优先权日:2001-02-21 标 题:Non-enzymatic large scale synthesis of RNA 发明人:KANAVARIOTI ANASTASSIA; DEAMER DAVID W; MONNARD PIERRE-ALAIN M; BERNASCONI CLAUDE F 摘要:This invention pertains to the development of methods that accomplish efficient, non-enzymatic, nucleic acid-directed (e.g. RNA-directed) nucleic acid (e.g. RNA) synthesis. In certain embodiments the methods provide conditions that favor oligouridylate synthesis with excellent yield and, at least, up to 30% regioselectivity favoring the RNA linkage. The methods preferably involve contacting, in the presence of lead ions (Pb 2+ ) and/or tin ions (Sn 2+ ) and, optionally, magnesium ions (Mg 2+ ), a template nucleic acid with a nucleotide derivatized with an imidazolide.
专利号:US-7855285-B2 优先权日:2005-06-14 标 题:Methods for selective N-9 glycosylation of purines 发明人:ROBINS MORRIS J; ZHONG MINGHONG 权利人:UNIV BRIGHAM YOUNG 摘要:A process for providing regiospecific and highly stereoselective synthesis of 9-β anomeric purine nucleoside analogs is described. The introduction of the sugar moiety on to 6-(azolyl)-substituted purine bases is performed so that highly stereoselective formation of the β anomers of only the 9 position regioisomers of the purine nucleoside analogs (either D or L enantiomers) is obtained. This regiospecific and stereoselective introduction of the sugar moiety allows the synthesis of nucleoside analogs, and in particular 2′-deoxy, 3′-deoxy, 2′-deoxy-2′-halo-arabino and 2′,3′-dideoxy-2′-halo-threo purine nucleoside analogs, in high yields without formation of the 7-positional regioisomers. Processes for providing novel 6-(azolyl)purines for the regiospecific and highly stereoselective synthesis of 9-β anomeric purine nucleoside analogs are described. The compounds are drugs or intermediates to drugs.
专利号:US-2008280855-A1 优先权日:2005-06-22 标 题 :Process For the Production of Intermediates For the Preparation of Tricyclic Benzimidazoles 发明人:CHIESA MARIA VITTORIA; PALMER ANDREAS; BUHR WILM; ZIMMERMANN PETER JAN; BREHM CHRISTOF; SIMON WOLFGANG-ALEXANDER; POSTIUS STEFAN; KROMER WOLFGANG; ZANOTTI-GEROSA ANTONIO 权利人:NYCOMED GMBH 摘要:The invention relates to a process for the synthesis of compounds of the formula 1-a and compounds of the formula 1-b. n n n n n n n n n n The compounds of the formula 1-a and the compounds of the formula 1-b, in which the substituents R1, R2, R3, and Ar have the meanings indicated in the description, are valuable intermediates for the preparation of pharmaceutically active compounds.
专利号:WO-2007141253-A1 优先权日:2006-06-07 标 题 :Process for the production of intermediates for the preparation of tricyclic imidazopyridines 发明人:PALMER ANDREAS; BUHR WILM; ZIMMERMANN PETER JAN; BREHM CHRISTOF; CHIESA MARIA VITTORIA; ZANOTTI-GEROSA ANTONIO 权利人:NYCOMED GMBH; PALMER ANDREAS; BUHR WILM; ZIMMERMANN PETER JAN; BREHM CHRISTOF; CHIESA MARIA VITTORIA; ZANOTTI-GEROSA ANTONIO 摘要:The invention relates to a process for the synthesis of compounds of the formula (1-a) and compounds of the formula (1-b). The compounds of the formula 1-a and the compounds of the formula 1-b, in which the substituents R1, R2, R3, and Arom have the meanings indicated in the description, are valuable intermediates for the preparation of pharmaceutically active compounds.
专利号:US-12054833-B2 优先权日:2020-07-29 标 题:Catalyst for synthesizing organic carbonate and method of producing thereof, electrode for synthesizing organic carbonate, cell for synthesizing organic carbonate, method of producing organic carbonate, and synthesis system 发明人:FUJINUMA NAOHIRO 权利人:SEKISUI CHEMICAL CO LTD 摘要:An organic carbonate synthesis catalyst for electrochemically synthesizing an organic carbonate from carbon monoxide, comprises: an active particle containing a metal element; and a porous carbon supporting the active particle.
专利号:US-12215435-B2 优先权日:2021-09-09 标 题 :Electrochemical cell, method for producing carbonyl compound, and synthesis system 发明人:FUJINUMA NAOHIRO 权利人:SEKISUI CHEMICAL CO LTD 摘要:The electrochemical cell is an electrochemical cell which electrochemically synthesizes at least one carbonyl compound selected from the group consisting of organic carbonates and organic oxalates from carbon monoxide, and has an electrolyte solution containing a redox species and a catalyst, and an electrode.
参考文献:10.1021/jm060495o 摘要:Vock CA, Scolaro C, Phillips AD, Scopelliti R, Sava G, Dyson PJ. Synthesis, characterization, and in vitro evaluation of novel ruthenium(II) eta6-arene imidazole complexes. J Med Chem. 2006 Sep 07;49(18):5552–61. doi: 10.1021/jm060495o. 参考文献:10.1021/jp802107m 摘要:Tsuzuki S, Arai AA, Nishikawa K. Conformational analysis of 1-butyl-3-methylimidazolium by CCSD(T) level ab initio calculations: effects of neighboring anions. J Phys Chem B. 2008 Jul 03;112(26):7739–47. doi: 10.1021/jp802107m.