CAS: 741709-63-7; 5-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)Picolinonitrile

相似化合物

1011722-07-8 1257553-74-4 1073354-14-9

上下游产品

2-Cyano-5-bromopyridine bis(pinacol)diborane 5-bromo-pyridine-2-carbaldehyde C-[5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridin-2-yl]-methylamineC-[5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-pyridin-2-yl]-methylamine tert-butyl 4-((5-(6-cyanopyridin-3-yl)-2-methoxybenzyloxy)methyl)-4-phenylpiperidine-1-carboxylate 5-(2-formylphenyl)pyridine-2-carbonitrile 5-[6-(3,4-dimethoxy-phenyl)-2-methyl-imidazo[1,2-b]pyridazin-3-yl]-[2,3']bipyridinyl-6'-carbonitrile

5-溴-2-吡啶甲醛置于(1,1'-Bis(Diphenylphosphino)Ferrocene)Palladium(II) Dichloride,Ammonium Hydroxide,碘,Potassium Acetate体系中,用 四氢呋喃,二甲基亚砜 作为反应溶剂,化学反应 29.0H,反应生成 2-氰基吡啶-5-硼酸频那酯
参考文献:Biological Evaluation Of Isothiazoloquinolones Containing Aromatic Heterocycles At The 7-Position: In Vitro Activity Of A Series Of Potent Antibacterial Agents That Are Effective Against Methicillin-Resistant Staphylococcus Aureus
标题:Biological Evaluation Of Isothiazoloquinolones Containing Aromatic Heterocycles At The 7-Position: In Vitro Activity Of A Series Of Potent Antibacterial Agents That Are Effective Against Methicillin-Resistant Staphylococcus Aureus
摘要:We Synthesized A Diverse Series Of 9H-Isothiazolo[5,4-B]Quinoline-3,4-Diones Containing Heteroaromatic Groups At The 7-Position Via Palladium-Catalyzed Cross-Coupling. Many Of These Compounds Demonstrated Potent Antistaphylococcal Activity (Mics <= 2 Mu G/ml) Against A Multi-Drug-Resistant Strain (Atcc 700699) And Low Cytotoxic Activity (Cc50 > 100 Mu M) Against The Human Cell Line Hep2 (Laryngeal Carcinoma). (C) 2005 Elsevier Ltd. All Rights Reserved.
DOI:10.1016/j.Bmcl.2005.11.064

专利信息

专利号:WO-2023141114-A2
优先权日:2022-01-18
标 题:Synthesis of boron-containing amidoxime reagents and their application to synthesize functionalized oxadiazole and quinazolinone derivatives

专利号:WO-2024159285-A1
优先权日:2023-01-30
标题 :Nav1.7- and/or nav1.8-inhibiting aryl pyridine compounds, processes for the preparation thereof, compositions, uses, methods for treatment using same, and kits
发明人：BARREIRO GABRIELA; SANT’ANA DANILO PEREIRA DE; MONTEIRO JÚLIA LAMMOGLIA; GAMBA LUIS EDUARDO REINA; LIMA LÃ?DIA MOREIRA; FRAGA CARLOS ALBERTO MANSSOUR; BARREIRO ELIEZER JESUS DE LACERDA
权利人:EUROFARMA LABORATORIOS S A; UNIV FEDERAL DO RIO DE JANEIRO – UFRJ
摘要:The present invention relates to Nav1.7- and/or Nav1.8-inhibiting aryl pyridine compounds. More specifically, the present invention relates to aryl pyridines comprising formula (I): (I), in which the substituents R1 to R10 are selected independently of the groups defined in the description, as well as to processes for preparing same, compositions comprising at least one of these compounds, uses, treatment methods for treating or preventing pain-related pathologies, and kits. The present invention pertains to the fields of medicinal chemistry and organic synthesis, as well as to the treatment of pain-related diseases.