CAS: 105752-11-2; 3-Amino-4-Iodopyridine

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上下游产品

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3-氨基-4-溴吡啶置于copper(L) Iodide,(1R,2R)-(-)-N,N'-二甲基-1,2-环己二胺,Sodium Iodide体系中,用 1,4-二氧六环 用作溶剂,化学反应 24.0H,以94%的收率获得3-氨基-4-碘吡啶
参考文献:单萜吲哚生物碱生物合成中的氮杂色胺底物
标题:单萜吲哚生物碱生物合成中的氮杂色胺底物
摘要:通过引入新的起始材料,可以劫持生物合成途径以产生新的化合物.在这里,我们通过用四种氮杂吲哚异构体之一替换吲哚来改变色胺,色胺是各种生物碱生物合成途径的起始底物.我们表明两种氮杂色胺底物可以成功地掺入长春花中单萜吲哚生物碱途径的产物中.非天然杂环在微生物和植物天然产物途径中的前体导向生物合成中的使用尚未得到广泛证明,并且先前未报道过成功掺入含有氮杂吲哚官能团的起始底物类似物.
Doi:10.1016/j.Chembiol.2009.11.016

专利信息

专利号:WO-2010001220-A1
优先权日:2008-07-01
标 题 :New 1,2,4-triazine derivatives and biological applications thereof
发明人：DESROY NICOLAS; DENIS ALEXIS; GERUSZ VINCENT; OLIVEIRA CHRYSTELLE; VONGSOUTHI VANIDA; MOREAU FRANCOISE; ESCAICH SONIA
权利人:MUTABILIS SA; DESROY NICOLAS; DENIS ALEXIS; GERUSZ VINCENT; OLIVEIRA CHRYSTELLE; VONGSOUTHI VANIDA; MOREAU FRANCOISE; ESCAICH SONIA
摘要:The invention relates to new 1,2,4-triazine derivatives of formula (I): wherein A, B, R2 and Y are defined in the application, their preparation and intermediates, their use as drugs and pharmaceutical compositions and associations containing them. The compounds of formula (I) are capable of inhibiting bacterial heptose synthesis.