CAS: 118289-07-9; (2,4,6-Trifluorophenyl)Methanol

相似化合物

58551-83-0 28314-80-9 79538-28-6

上下游产品

2,4,6-trifluorobenzoic acid 2,4,6-trifluorobenzaldehyde 1,3,5-trifluorobenzene 2-(2,4,6-trifluorophenyl)acetonitrile

1,3,5-三氟苯置于正丁基锂,钾硼氢,N,N-二甲基甲酰胺体系中,用 四氢呋喃 用作溶剂,化学反应 6.5H,反应生成2,4,6-三氟苯甲醇
参考文献:一种2,4,6-三氟苄胺化合物的制备方法
标题:一种2,4,6-三氟苄胺化合物的制备方法
摘要:本发明涉及2,4,6-三氟苄胺的制备方法,本发明以1,3,5-三氟苯为原料,经锂化,醛基化,还原,卤代和置换反应制备2,4,6-三氟苄胺方法,反应条件温和,可操作性强,原子经济性高,工艺简单易于实现工业化,并且产品纯度高,质量稳定,符合作为中间体的使用要求.

专利信息

专利号:US-10745342-B2
优先权日:2018-07-05
标 题 :Synthesis method of 2,4,6-trifluorobenzylamine
发明人：YUAN QILIANG; QIAN JIE; LAI XIN; CHEN HAIFENG; CHEN YINHAO; WANG CHAO
权利人:ZHEJIANG ZHONGXIN FLUORIDE MAT CO LTD; SHAOXING ZHONGKE BAIYUN CHEMICAL TECH CO LTD
摘要:The disclosure provides a synthesis method of 2,4,6-trifluorobenzylamine, belonging to the technical field of chemical synthesis. The synthesis method is characterized by comprising the following steps: (1) allowing pentachlorobenzonitrile as a raw material to undergo fluoridation reaction with a fluoridation agent based on 2,4,6-trifluoro-3,5-dichlorobenzonitrile as a solvent to obtain 2,4,6-trifluoro-3,5-dichlorobenzonitrile; (2) hydrogenating the obtained 2,4,6-trifluoro-3,5-dichlorobenzonitrile with hydrogen in the presence of organic carboxylic acid, based, on palladium carbon as a catalyst to obtain 2,4,6-trifluoro-3,5-dichlorobenzylamine; and (3) hydrogenating the obtained 2,4,6-trifluoro-3,5-dichlorobenzylamine with hydrogen in a solvent in the presence of a catalyst to obtain 2,4,6-trifluorobenzylamine. The synthesis method has the advantages of low raw material cost, short reaction steps, high reaction yield, good product purity simple operation and the like, and is suitable for industrial production.

专利号:US-2020207702-A1
优先权日:2018-07-05
标 题:Synthesis method of 2,4,6-trifluorobenzylamine