专利号:US-5719283-A 优先权日:1990-06-20 标 题:Intermediates useful in the synthesis of pyrazolopyrimidinone antianginal agents 发明人:BELL ANDREW SIMON; BROWN DAVID; TERRETT NICHOLAS KENNETH 权利人:PFIZER 摘要:Compounds of the formula ##STR1## wherein R 1 is H, C 1 -C 3 alkyl, C 3 -C 5 cycloalkyl or C 1 -C 3 perfluoroalkyl; n R 2 is H, C 1 -C 6 alkyl optionally substituted by OH, C 1 -C 3 alkoxy or C 3 -C 6 cycloalkyl, or C 1 -C 3 perfluoroalkyl; n R 3 is H, C 1 -C 6 alkyl, C 3 -C 6 alkenyl, C 3 -C 6 alkynyl, C 3 -C 7 cycloalkyl, C 1 -C 6 perfluoroalkyl or (C 3 -C 6 cycloalkyl)C 1 -C 6 alkyl; n and Y is chloro, bromo, or fluoro. n The above compounds are intermediates useful in the synthesis of certain pyrazolopyrimidinones which inhibit cyclic guanosine 3', 5'-monophosphate phosphodiesterase.
专利号:CN-103044330-B 优先权日:2013-01-14 标 题:A New Process for the Green Synthesis of Sildenafil Intermediate 4-Amino-1-Methyl-3-n-Propylpyrazole-5-Carboxamide
专利号:CN-103044330-A 优先权日:2013-01-14 标 题:A New Process for the Green Synthesis of Sildenafil Intermediate 4-Amino-1-Methyl-3-n-Propylpyrazole-5-Carboxamide
专利号:US-6960661-B2 优先权日:2001-01-27 标题:[7-(3-chloro-4-methoxybenzlamino)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-ylmethoxy]acetic acid, synthesis thereof and intermediates used therein 发明人:EGGENWEILER HANS-MICHAEL 权利人:MERCK PATENT GMBH 摘要:[7-(3-chloro-4-methoxybenzylamino)-1-methyl-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-ylmethoxy]acetic acid, n n n is disclosed, as well as a process for its preperation and intermediates in the process of preparing the same.
专利号:CN-105622512-A 优先权日:2015-12-16 标题:Nitrolation Synthesis Process of Sildenafil Intermediate Suitable for Industrialization
参考文献:10.1007/978-981-19-2734-8_1 摘要:Tiwari VK, Kumar A, Rajkhowa S, Tripathi G, Singh AK. Green Chemistry: Introduction to the Basic Principles. 2022. In: Green Chemistry.