CAS: 16273-37-3; 3-Chloromandelic Acid

相似化合物

61008-98-8 153294-00-9 32222-43-8

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CAS号7677-24-9 三甲基氰硅烷 | CAS号587-04-2 3-氯苯甲醛 | CAS号75-25-2 三溴甲烷 | CAS号99-02-5 3-氯苯乙酮 | CAS号56-37-1 三乙基苄基氯化铵(TEBAC) | CAS号67-66-3 氯仿 | CAS号75-77-4 三甲基氯硅烷 | CAS号151-50-8 氰化钾 | CAS号587-04-2 3-氯苯甲醛 | CAS号535-80-8 间氯苯甲酸 | CAS号80051-04-3 (R)-1-(3-氯苯基)-1... | CAS号618-48-4 3-氯苯甲酰胺 | CAS号32222-44-9 (S)-2-(3-氯苯基)-2... | CAS号22868-31-1 2-(3-氯苯基)苯并[d]噻唑 | CAS号16273-37-3 3-氯扁桃酸 | CAS号65-85-0 苯甲酸

2-(3-Chlorophenyl)-2-((Trimethylsilyl)Oxy)Acetonitrile置于盐酸体系中,化学反应 5.0H,反应生成3-氯扁桃酸
参考文献:Lee,Donald G.; Chen,Tao,Journal Of The American Chemical Society,1993,Vol. 115,# 24,P. 11231-11236
标题:Lee,Donald G.; Chen,Tao,Journal Of The American Chemical Society,1993,Vol. 115,# 24,P. 11231-11236

专利信息

专利号:US-8846916-B2
优先权日:2009-05-11
标题:Sitagliptin synthesis
发明人：GORE VINAYAK GOVIND; GADAKAR MAHESHKUMAR; BHOSLE PRIYANKA; SHINDE SURESH
权利人:GORE VINAYAK GOVIND; GADAKAR MAHESHKUMAR; BHOSLE PRIYANKA; SHINDE SURESH; GENERICS UK LTD
摘要:The present invention relates to novel processes for the preparation of enantiomerically enriched β-amino acid derivatives such as β-amino esters useful for the synthesis of enantiomerically enriched biologically active molecules such as sitagliptin. The key step involves the resolution of the racemate with mandelic acid.

专利号:WO-2012142983-A1
优先权日:2011-04-19
标 题 :Optically active salts of (3ar,4s,6r,6as)-6-amino-2,2-dimethyltetrahydro-3ah- cyclopenta-[d] [1,3]dioxol-4-ol and a method of their preparation
发明人：LUSTIG PETR; HEJTMANKOVA LUDMILA
权利人:ZENTIVA KS; LUSTIG PETR; HEJTMANKOVA LUDMILA
摘要:Diastereomeric salts of the compound of formula I with D-(-)-mandelic and R-(-)-3- chloromandelic acid, a method of for the preparation thereof and their use in the synthesis of the drug ticagrelor.

专利号:WO-2021224280-A1
优先权日:2020-05-05
标题:Synthesis of a sickle cell disease agent and intermediates thereof
发明人：JUDGE THOMAS; SCHROEDER MEL C; KOPEL LUCAS C; EKLOV BRIAN M
权利人:DIPHARMA FRANCIS SRL
摘要:New processes for preparing 2-hydroxy-6-((2-(1-isopropyl-1H-pyrazol-5- yl)pyridin-3-yl)methoxy)benzaldehyde, an agent developed for the treatment of sickle cell disease, and intermediates thereof, are provided herein.

专利号:US-8796488-B2
优先权日:2010-01-29
标 题:Process for the preparation of lacosamide
发明人：BOLOGNA ALBERTO; CASTOLDI PATRIZIA; VERGANI DOMENICO; BERTOLINI GIORGIO
权利人:BOLOGNA ALBERTO; CASTOLDI PATRIZIA; VERGANI DOMENICO; BERTOLINI GIORGIO; EUTICALS SPA
摘要:A novel process for the synthesis of Lacosamide using D,L-serine as starting material is described, where the methylation reaction of hydroxyl is carried out using an inexpensive base such as NaOH and an inexpensive alkylating agent, non-toxic and non-carcinogenic, such as methyl p-toluenesulfonate; the R enantiomer is isolated from the racemic mixture of Lacosamide after selective hydrolysis of the acetamide, salification of the racemic mixture with a chiral acid (HX*) in an organic solvent, resolution of the diastereoisomeric mixture, preferably by precipitation of the R enantiomer, and subsequent acetylation of the optically pure intermediate.

专利号:CN-106467470-B
优先权日:2015-08-19
标 题 :Novel chiral metal complexes and their use in synthesis of metal complexes1H NMR Spectroscopy for chirality of charged CompoundsUse of

专利号:CN-113355367-B
优先权日:2018-03-22
标题 :Application of ketoacid reductase in synthesis of chiral aromatic 2-hydroxy acid