CAS: 2905-24-0; 3-Bromobenzenesulfonyl Chloride

上下游产品

CAS号591-19-5 3-溴苯胺 | CAS号89598-96-9 3-溴苯硼酸 | CAS号308283-47-8 N-叔丁基-3-溴苯磺酰胺 | CAS号937014-80-7 4-(3-溴-苯磺酰基)-哌嗪... | CAS号188062-33-1 2,2-dimethylpro... | CAS号214210-14-7 1-((3-溴苯基)磺酰基)吡咯烷 | CAS号876694-43-8 3-溴-N-环丙基苯磺酰胺 | CAS号871269-08-8 N-异丙基-3-溴苯磺酰胺 | CAS号89599-01-9 3-溴苯磺酰胺 | CAS号871269-12-4 1-((3-溴苯基)磺酰基)哌啶 | CAS号625470-36-2 N-苄基-3-溴苯磺酰胺 | CAS号6320-01-0 3-溴苯硫酚

3-溴苯磺酰肼置于n-氯代丁二酰亚胺体系中,用 乙腈 用作溶剂,化学反应 2.0H,以99%的收率获得3-溴苯磺酰氯
参考文献:从磺酰肼轻松合成磺酰氯/溴化物
标题:从磺酰肼轻松合成磺酰氯/溴化物
摘要:描述了一种使用 Nxs(x = Cl 或 Br)从磺酰肼高效合成磺酰氯/溴化物并在后期转化为几个其他官能团的简单快速方法.多种亲核试剂可以参与这种转化,从而可以合成复杂的磺酰胺和磺酸盐.在大多数情况下,这些反应具有高度选择性,简单且清洁,以优异的收率提供产品.
Doi:10.3390/molecules26185551

专利信息

专利号:US-8642809-B2
优先权日:2007-09-25
标 题:Methods of synthesis of certain hydroxamic acid compounds
发明人：REISCH HELGE A; LEEMING PETER; RAJE PRASAD S
权利人:REISCH HELGE A; LEEMING PETER; RAJE PRASAD S; TOPOTARGET UK LTD
摘要:The present invention pertains to the general field of chemical synthesis, and more particularly to methods for the synthesis of certain hydroxamic acid compounds, and in particular, (E)-N-hydroxy-3-(3-phenylsulfamoyl-phenyl)-acrylamide, also known as PXD101 and Belinostat®, comprising, for example, the steps of: (SAF) sulfonamide formation; (PUR C ) optional purification; (AAA) alkenyl-acid addition, comprising: either (i): the steps of, in order: (ACAEA) alkenyl-carboxylic acid ester addition; (PUR E ) optional purification; and (CAD) carboxylic acid deprotection; or (ii): the step of: (ACAA) alkenyl-carboxylic acid addition; (PUR F ) optional purification; (HAF) hydroxamic acid formation; and (PUR G ) optional purification.

专利号:US-2025188046-A1
优先权日:2023-12-08
标题:Ultrafast flow synthesis of functionalized sulfonyl fluorides and subsequent sufex connections via lithiated chemistry
发明人：KIM DONG-PYO; KANG JI-HO
权利人:POSTECH RES & BUSINESS DEV FOUND
摘要:Disclosed are ultrafast flow synthesis of functionalized sulfonyl fluorides and subsequent SuFEx connections via lithiated chemistry. In detail, a method of synthesizing an ortho-functionalized benzenesulfonyl fluoride derivative, the method comprises (a) reacting a benzenesulfonyl fluoride derivative represented by structural formula 1 with an organolithium represented by structural formula 2, thus synthesizing an intermediate represented by structural formula 3 in reaction scheme 1 and (b) reacting the intermediate with an electrophile, thus synthesizing a compound represented by structural formula 4 or a compound represented by structural formula 4′. The present disclosure enables the synthesis of several functionalized sulfonyl fluorides within a few seconds under mild temperature conditions in addition to the chemistry of Sulfonyl Fluoride Exchange (SuFEx), which is a next-generation click chemistry, so that sulfonyl fluoride, the main reactant of the SuFEx reaction, can be efficiently secured.

专利号:US-2010286279-A1
优先权日:2007-09-25
标题 :Methods of Synthesis of Certain Hydroxamic Acid Compounds

专利号:CA-2700173-A1
优先权日:2007-09-25
标 题 :Methods of synthesis of certain hydroxamic acid compounds

专利号:CN-117720498-A
优先权日:2023-11-03
标 题 :Synthesis of a new coumarin derivative containing a sulfonamide fragment and preparation method and application of its composition

专利号:EP-2203421-B1
优先权日:2007-09-25
标题:Methods of synthesis of certain n-hydroxy-3-(3-phenylsulfamoyl-phenyl)-acrylamide compounds