CAS: 374068-01-6; 2-Chloropyrimidine-5-Carboxylic Acid

相似化合物

1753-50-0 89793-12-4 287714-35-6

上下游产品

2-氯嘧啶-5-羧酸乙酯 Ethyl 2-Chloropyrimidine-5-Carboxylate 89793-12-4
2-羟基嘧啶-5-羧酸 2-Hydroxypyrimidine-5-Carboxylic Acid 38324-83-3

2-羟基嘧啶-5-羧酸乙酯置于水,Sodium Hydroxide,三氯氧磷体系中,用 四氢呋喃 用作溶剂,化学反应 4.5H,反应生成2-氯嘧啶-5-羧酸
参考文献:Heteroaromatic Compounds As Inhibitors Of Stearoyl-Coenzyme A Delta-9 Desaturase
标题:Heteroaromatic Compounds As Inhibitors Of Stearoyl-Coenzyme A Delta-9 Desaturase
摘要:结构式i的杂环芳香化合物相对于其他已知的硬脂酰辅酶a去饱和酶(Scd1),是选择性抑制剂.本发明的化合物对于预防和治疗与异常脂质合成和代谢相关的疾病非常有用,包括心血管疾病,如动脉粥样硬化;肥胖;糖尿病;神经系统疾病;代谢综合征;胰岛素抵抗;和肝脂肪变性.

专利信息

专利号:US-10906888-B2
优先权日:2016-07-14
标 题:Pyrimidine carboxamides as inhibitors of Vanin-1 enzyme
发明人：CASIMIRO-GARCIA AGUSTIN; STROHBACH JOSEPH WALTER; HEPWORTH DAVID; LOVERING FRANK ELDRIDGE; CHOI CHULHO; ALLAIS CHRISTOPHE PHILIPPE; WRIGHT STEPHEN WAYNE
权利人:PFIZER
摘要:Compounds, pharmaceutically acceptable salts thereof, are disclosed wherein the compounds have the structure of (I) as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

专利号:US-2010004245-A1
优先权日:2006-10-20
标 题:Azacycloalkane derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase
发明人：OBALLA RENATA M; DESCHENES DENIS; GAGNON MARC; LEBLANC YVES; POWELL DAVID; RAMTOHUL YEEMAN K
权利人:MERCK FROSST CANADA LTD
摘要:Azacycloalkane derivatives of structural formula (I) are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis.

专利号:US-2011152295-A1
优先权日:2008-09-08
标 题:Heteroaromatic compounds as inhibitors of stearoyl-coenzyme a delta-9 desaturase
发明人：LECLERC JEAN-PHILIPPE; LI CHUN SING; RAMTOHUL YEEMAN K
权利人:LECLERC JEAN-PHILIPPE; LI CHUN SING; RAMTOHUL YEEMAN K
摘要:Heteroaromatic compounds of structural formula I are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis.

专利号:CN-103664796-A
优先权日:2013-12-06
标 题 :Synthesis of 5-[2-(5-carboxy-pyrimidinyl)]-1,3-benzenedicarboxylic acid

专利号:US-RE48547-E
优先权日:2010-08-23
标 题:Aminopyrimidinecarboxamides as CXCR2 modulators
发明人：MAEDA DEAN Y; ZEBALA JOHN A; SCHULER AARON D
权利人:SYNTRIX BIOSYSTEMS INC
摘要:There are disclosed aminopyrimidinecarboxamide compounds useful as pharmaceutical agents, synthesis processes, and pharmaceutical compositions which include aminopyrimidinecarboxamides compounds. More specifically, there is disclosed a genus of CXCR2 inhibitor compounds that are useful for treating a variety of inflammatory and neoplastic disorders.