CAS: 52554-28-6; Methyl 2,3,5-Tri-O-Acetyl-D-Ribofuranoside

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CAS号28708-32-9 四乙酰核糖

D-吡喃核糖置于吡啶,硫酸体系中,化学反应 4.0H,反应生成 1-甲氧基-2,3,5-三乙酰氧基-D-呋喃核糖苷
参考文献:Glycosides And Glycoconjugates Of The Diterpenoid Isosteviol With A 1,2,3-Triazolyl Moiety: Synthesis And Cytotoxicity Evaluation
标题:Glycosides And Glycoconjugates Of The Diterpenoid Isosteviol With A 1,2,3-Triazolyl Moiety: Synthesis And Cytotoxicity Evaluation
摘要:Several Glycoconjugates Of The Diterpenoid Isosteviol (16-Oxo-Ent-Beyeran-19-Oic Acid) With A 1,2,3-Triazolyl Moiety Were Synthesized,And Their Cytotoxicity Was Evaluated Against Some Human Cancer And Normal Cell Lines. Most Of The Synthesized Compounds Demonstrated Weak Inhibitory Activities Against The M-Hela And Mcf-7 Human Cancer Cell Lines. Three Lead Compounds,54,56 And 57,Exhibited High Selective Cytotoxic Activity Against M-Hela Cells (Ic50 = 1.7-1.9 Mu M) That Corresponded To The Activity Of The Anticancer Drug Doxorubicin (Ic50 = 3.0 Mu M). Moreover,The Lead Compounds Were Not Cytotoxic With Respect To A Chang Liver Human Normal Cell Line (Ic50 > 100 Mu M),Whereas Doxorubicin Was Cytotoxic To This Cell Line (Ic50 = 3.0 Mu M). It Was Found That Cytotoxic Activity Of The Lead Compounds Is Due To Induction Of Apoptosis Proceeding Along The Mitochondrial Pathway. The Present Findings Suggest That 1,2,3-Triazolyl-Ring-Containing Glycoconjugates Of Isosteviol Are A Promising Scaffold For The Design Of Novel Anticancer Agents.
DOI:10.1021/acs.Jnatprod.0C00134

专利信息

专利号:US-6583297-B2
优先权日:2000-08-02
标题:Process and intermediate compounds for the preparation of pyrrolidines
发明人：HOLLINGSWORTH RAWLE I
权利人:UNIV MICHIGAN STATE
摘要:Processes for the preparation of pyrrolidones ( 7 and 8 ) and pyrrolidines ( 9 and 10 ) from tri-O-acetyl-D-erythro-4-pentulosonic acid esters are described. The compounds are aza sugar analogs of D-ribofuranoside and are intermediates to drugs which regulate nucleoside and nucleic acid synthesis.