CAS: 621-36-3; 2-(M-Tolyl)Acetic Acid

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CAS号201230-82-2 carbon monoxide | CAS号620-19-9 间甲基氯化苄 | CAS号40061-55-0 间甲苯乙酸乙酯 | CAS号620-13-3 3-甲基苄溴 | CAS号85267-34-1 N,N-diethyl-N-(... | CAS号1878-67-7 3-溴苯乙酸 | CAS号544-97-8 二甲基锌 | CAS号108-38-3 间二甲苯 | CAS号585-74-0 间甲基苯乙酮 | CAS号7023-80-5 2-diazonio-1-(3... | CAS号105279-22-9 3-[(3-methylphe... | CAS号1086390-21-7 6-[2-(m-tolyl)a... | CAS号4242-15-3 5-甲基-2-四氢萘酮 | CAS号40061-55-0 间甲苯乙酸乙酯 | CAS号203314-29-8 2-(2-溴-5-甲基苯基)乙酸 | CAS号220991-52-6 (2-碘-5-甲基-苯基)-乙酸 | CAS号1875-89-4 3-甲基苯乙醇 | CAS号72927-80-1 2-甲苯基乙醛 | CAS号61924-25-2 3-甲基苄基异氰酸酯 | CAS号53088-69-0 3-甲基苯乙酸甲酯

N,N-二甲基氨基甲基-1-甲基-4-苯置于disodium Hydrogenphosphate,(4,4'-Di-Tert-Butyl-2,2'-Dipyridyl)-Bis-(2-Phenylpyridine(-1H))-Iridium(Iii) Hexafluorophosphate,Caesium Carbonate体系中,用 乙醚,N,N-二甲基甲酰胺 作为反应溶剂,化学反应 36.0H,反应生成 3-甲基苯乙酸
参考文献:四烷基铵盐的可见光驱动的无外部还原剂交叉电偶偶联
标题:四烷基铵盐的可见光驱动的无外部还原剂交叉电偶偶联
摘要:两个亲电子试剂之间的交叉亲电子试剂偶联是在化学计量外部还原剂存在下反应生成 Cc 键的有效且经济的方法.在此,我们报告了一种通过可见光光氧化还原催化实现第一个无外部还原剂的交叉亲电子偶联的新策略.各种带有伯,仲和叔 Cn 键的四烷基铵盐与醛/酮和 Co2 进行选择性偶联.值得注意的是,原位反应生成的副产物三甲胺被有效地用作电子供体.此外,该协议表现出温和的反应条件,低催化剂负载,广泛的底物范围,非常好的官能团耐受性和容易的可扩展性.机理研究表明,苄基自由基和阴离子可能是通过光催化产生的关键中间体,
DOI:10.1021/jacs.8B08792

专利信息

专利号:US-2007015260-A1
优先权日:2002-03-14
标 题:Synthesis of synthons for the manufacture of bioactive compounds
发明人：WONG CHI-HUEY; LIU JUNJIE; DESANTIS GRACE; BURK MARK
权利人:SCRIPPS RESEARCH INST
摘要:The present invention is based on the discovery that 2-deoxyribose-5-phosphate aldolase (DERA, EC 4.1.2.4) and variants thereof can be used to catalyze sequential asymmetric aldol reactions between a wide variety of donor and acceptor aldehydes. The reaction products typically contain at least two new stereogenic centers and can be produced in enantiomerically pure form. As such, DERA catalyzed asymmetric aldol chemistry can be exploited to produce synthons for the synthesis of a variety of bioactive molecules.

专利号:US-12037623-B2
优先权日:2018-07-09
标 题 :Enzymatic synthesis of 4′-ethynyl nucleoside analogs
发明人：HUFFMAN MARK A; FRYSZKOWSKA ANNA; KOLEV JOSHUA N; DEVINE PAUL N; CAMPOS KEVIN R; TRUPPO MATTHEW; NAWRAT CHRISTOPHER C
权利人:MERCK SHARP & DOHME; MERCK SHARP & DOHME LLC
摘要:The present invention relates to an enzymatic synthesis of 4′-ethynyl-2′-deoxy nucleosides and analogs thereof, for example EFdA, that eliminates the use of protecting groups on the intermediates, improves the stereoselectivity of glycosylation and reduces the number of process steps needed to make said compounds. It also relates to the novel intermediates employed in the process.

专利号:US-9181292-B2
优先权日:2011-01-05
标题 :Methods for preparation of glycosphingolipids and uses thereof
发明人：LIANG PI-HUI
权利人:LIANG PI-HUI
摘要:Methods for synthesis and preparation of alpha-glycosphingolipids are provided. Methods for synthesis of α-galactosyl ceramide, and pharmaceutically active analogs and variants thereof are provided. Novel alpha-glycosphingolipids are provided, wherein the compounds are immunogenic compounds which serve as ligands for NKT (natural killer T) cells.

专利号:US-4216171-A
优先权日:1977-11-21
标题:Novel compositions having a base of aminoalkoxy amines
发明人：LE LUDEC JOEL; SOULA GERARD
权利人:RHONE POULENC IND
摘要:Compositions containing at least one aminoalkoxy amine of the formula: (I) in which x is a whole number of from 1 to 3, are provided. They are prepared by cyanoethylation of tris(5-hydroxy-3-oxa-pentyl)amine with acrylonitrile followed by hydrogenation. They are useful as manufacturing intermediates, additives for lubricating oils, and in the synthesis of polyurethanes.

专利号:US-6664282-B2
优先权日:1999-09-17
标 题:Synthesis of [3,5,7]-1H-imidazo [1,5-a]imidazol-2 (3H)- one compounds
发明人：ELABDELLAOUI HASSAN M; OSTRESH JOHN M; HOUGHTEN RICHARD A
权利人:TORREY PINES INST
摘要:Individual substituted [3,5,7]-1H-imidazo[1,5-a]imidazol-2(3H)-one compounds and their pharmaceutically-acceptable salts are disclosed, as are libraries of such compounds. Methods of preparing and using the libraries of compounds as well as individual compounds of the libraries are also disclosed.

专利号:US-3553260-A
优先权日:1967-05-29
标 题 :Radiopaque derivatives of alpha-phenoxy-phenylacetic acid
发明人：FELDER ERNST; PITRE DAVIDE
权利人:BRACCO IND CHIMICA SPA
摘要:A - (3 - N-ALKYL-N-ACETYLAMINO-2,4,6-TRIIODOPHENOXY)PHENYLACETIC ACID AND CLOSELY RELATED DERIVATIVES OF THE FORMULA 1,3,5-TRI(I-),2-((R3-PHENYL)-CH(-COOH)-O-),4-(R2-CO- N(-R1)-)BENZENE WHEREIN R1 IS LOWER ALKYL, R2 IS HYDROGEN OR LOWER ALKYL, AND R3 IS HYDROGEN, HALOGEN OR LOWER ALKYL, AND THE PHYSIOLOGICALLY TOLERATED, WATER SOLUBLE METAL OR AMINE SALTS THEREOF ARE RADIOPAQUE, TEND TO ACCUMULATE IN THE GALL BLADDER WHEN APPLIIED ORALLY, AND ARE NON-TOXIC IN EFFECTIVE AMOUNTS. THE CORRESPONDING LOWER ALKYL ESTERS ARE INTERMEDIATES IN THE SYNTHESIS OF THE ACIDS AND SALTS.