CAS: 676-58-4; Magnesium Chloride Methanide

上下游产品

CAS号74-87-3 氯甲烷 | CAS号105949-28-8 N,N-diethyl-3-(... | CAS号112182-59-9 2,2-dimethyl-5-... | CAS号107971-38-0 PHENYL 3,4-DIHY... | CAS号10545-34-3 3-Bromopropyltr... | CAS号106685-74-9 1-(2,4,6-trimet... | CAS号10553-07-8 1H-Indole, 7-Me... | CAS号61149-54-0 5-甲基-4-硝基吲哚 | CAS号10528-64-0 4-(4-异丙基苯基)-2-丁酮 | CAS号1104083-23-9 3-羟基-3-甲基氮杂环丁烷-... | CAS号41309-43-7 2-溴乙烯基三甲基硅烷

氯甲烷置于magnesium体系中,用 四氢呋喃 作为反应溶剂,化学反应生成 甲基氯化镁
参考文献:铁催化酰基氯与格氏试剂的交叉偶联反应.温和,通用,方便地合成脂肪族和芳香族酮.
标题:铁催化酰基氯与格氏试剂的交叉偶联反应.温和,通用,方便地合成脂肪族和芳香族酮.
摘要:在催化量的三(乙酰丙酮)铁(iii),Fe(acac)3存在下,室温下将酰氯与格氏试剂偶联.对于两种反应物而言,该反应是通用的,并且提供了用于合成脂族和芳族酮的非常温和且方便的方法.
DOI:10.1016/s0040-4039(01)81525-2

专利信息

专利号:WO-2022256490-A9
优先权日:2021-06-03
标题:Improved synthesis of phosphoramidates for the treatment of hepatitis b virus
发明人：LOCKWOOD MARK
权利人:ANTIOS THERAPEUTICS INC
摘要:The synthesis of phosphoramidate prodrugs useful in the treatment of viral infections is disclosed. Specifically, an improved synthesis of phosphoramidate nucleotides useful in the treatment of Hepatitis B virus is disclosed.

专利号:US-7615169-B2
优先权日:2004-09-20
标题 :Method for synthesis of colloidal nanoparticles
发明人：STROUSE GEOFFREY FIELDING; GERBEC JEFFREY A; MAGANA DONNY
权利人:UNIV CALIFORNIA
摘要:A method for synthesis of high quality colloidal nanoparticles using comprises a high heating rate process. Irradiation of single mode, high power, microwave is a particularly well suited technique to realize high quality semiconductor nanoparticles. The use of microwave radiation effectively automates the synthesis, and more importantly, permits the use of a continuous flow microwave reactor for commercial preparation of the high quality colloidal nanoparticles.

专利号:US-4125735-A
优先权日:1975-03-20
标 题 :Synthesis of esters of acetylenic alcohols
发明人：CLOSE RALPH E; OROSHNIK WILLIAM
权利人:SCM CORP
摘要:A process for the synthesis of perfume products, Vitamin E and intermediates described herein involving a coupling reaction. For instance, a process for the synthesis of dehydrophytol and Vitamin E comprising forming a C15 acetylene from hexahydropseudoionone and then coupling said acetylene with 1-acetoxy-4-chloro-3-methylbut-2-ene to form a C20 acetoxy-enyne. The latter is readily subjected to partial hydrogenation and saponification in that order to form a dehydrophytol, a useful intermediate for the synthesis of Vitamin E and other products.

专利号:US-8426612-B2
优先权日:2009-04-22
标 题:Synthesis of 3-{[(2R)-1-methylpyrrolidin-2-yl]methyl}-5[2-(phenylsulfonyl)ethyl]-1H-indole
发明人：SERAFINI SIRO; CASTELLIN ANDREA; DAL SANTO CLAUDIO
权利人:SERAFINI SIRO; CASTELLIN ANDREA; DAL SANTO CLAUDIO; ITALIANA SINT SPA
摘要:The present invention refers to the synthesis of 3-{[(2R)-1-methylpyrrolidin-2-yl]methyl}-5-[2-(phenylsulfonyl)ethyl]-1H-indole, a drug known by the name Eletriptan, or of its salts. In particular, the present invention regards a process for the synthesis of Eletriptan or of its salt, comprising the following steps: a) Salifying the intermediate of Formula (6), using a dicarboxylic acid to obtain a derived salt; b) Optionally, purifying said raw salt obtained according to step a) by solvent crystallization to obtain a purified salt of the intermediate of Formula (6); c) Converting said salt of the intermediate of formula (6) according to step a) or said purified salt according to step b) into an intermediate of formula (10); d) Converting the intermediate of Formula (10) into Eletriptan or its salt.

专利号:US-7927516-B2
优先权日:2004-09-20
标题 :Method for synthesis of colloidal nanoparticles
发明人：STROUSE GEOFFREY F; GERBEC JEFFREY A; MAGANA DONNY
权利人:UNIV CALIFORNIA
摘要:A method for synthesis of high quality colloidal nanoparticles using comprises a high heating rate process. Irradiation of single mode, high power, microwave is a particularly well suited technique to realize high quality semiconductor nanoparticles. The use of microwave radiation effectively automates the synthesis, and more importantly, permits the use of a continuous flow microwave reactor for commercial preparation of the high quality colloidal nanoparticles.

专利号:US-6022984-A
优先权日:1998-07-27
标 题:Efficient synthesis of furan sulfonamide compounds useful in the synthesis of new IL-1 inhibitors
发明人：URBAN FRANK J; JASYS VYTAUTAS J
权利人:PFIZER
摘要:An efficent synthesis of furan sulfonamide compounds of formula ##STR1## comprising reacting a compound of formula 11 with a Grignard reagent in a reaction inert solvent, wherein R' is (C 1 -C 6 )alkyl. The compound of formula II is prepared by reacting a compound of formula III with a compound of formula IV wherein R' is (C 1 -C 6 )alkyl with a chorinating reagent and an acid scaverger in an inert solvent. The invention also includes a novel compound of the formula ##STR2## wherein R' is (C 1 -C 6 )alkyl and Q is halo, hydroxy or amino.