CAS: 82957-06-0; 6-Hydroxy-2-Naphthimidamide Methanesulfonate Salt

相似化合物

151391-00-3 58200-88-7 66217-10-5

甲基6-羟基-2-萘imidate置于氨体系中,用 甲醇 作为反应溶剂,化学反应 3.0H,反应生成 6-脒-2-萘酚 甲基磺酸
参考文献:Synthesis And Structure-Activity Study Of Protease Inhibitors. Iv. Amidinonaphthols And Related Acyl Derivatives.
标题:Synthesis And Structure-Activity Study Of Protease Inhibitors. Iv. Amidinonaphthols And Related Acyl Derivatives.
摘要:合成了多种 Amidinonaphthol 及其酰基衍生物,并评估了它们对胰蛋白酶,纤溶酶,激肽释放酶,凝血酶,Clr 和 Cls 以及体外补体介导溶血的抑制活性.发现 6-Amidino-2-萘基 4-胍基苯甲酸酯(74,Fut-175)具有强大的抑制活性,尤其对胰蛋白酶(ic50:0.02 μm),Clr(ic50:0.1 μm)和 Cls(ic50:0.02 μm),并且在抑制补体介导溶血方面非常有效(ic50:0.03 μm).此外,Fut-175 在全身性福斯曼休克反应中显示出显著的疗效,该反应中补体系统作为致病因素的作用已被充分证实.
DOI:10.1248/cpb.33.1458

专利信息

专利号:US-2025188022-A1
优先权日:2022-02-07
标 题 :Process for the preparation of nafamostat, camostat and their derivatives
发明人：AHMED RIYAZ; KUMAR GULSHAN; MAHAJAN SHEENA; Verma Praveen Kumar; CHAM PANKAJ SINGH; KUMAR AMIT; AHMED QAZI NAVEED; REDDY DUMBALA SRINIVASA; SHANKAR RAVI; SINGH PARVINDER PAL
权利人:COUNCIL SCIENT IND RES
摘要:The invention provides a novel, economical and practical route for the synthesis of an ester from acid and alcoholic functionalities using Trihalotriazine as coupling agent. Specifically, the invention provides a novel, economical and practical route for the preparation of Nafamostat and Camostat. Synthesis of p-guanidinobenzoic acid (Al) was also achieved from thiourea and p-aminobenzoic acid by using trihalotriazine as coupling reagent.

专利号:CN-117986161-A
优先权日:2024-02-01
标题 :Synthesis method of high-purity anti-hemagglutination medicament

专利号:CN-119504499-A
优先权日:2024-11-13
标题 :Synthesis method of 6-amidino-2-naphthol mesylate