CAS: 139-02-6; Sodium Phenolate

该化合物是苯酚的有机化合物,其产物是氢氧基组(-OH),由离子离子取代,看起来是白色到白色晶状固体,在水中高度溶解,由于存在苯酸盐离子而形成基本溶液. 苯甲酸钠具有很强的碱特性,在各种应用中有用,包括作为有机合成的试剂和抗菌剂. 它展示了抗微生物活动,允许将其用于制药配方和防腐剂. 此外,钠苯甲酸盐可以作为化学反应中的核分裂剂,参与电离性芳香替代和其他有机变异.安全考虑包括它可能造成皮肤和眼刺激,在实验室环境中应当以适当的防范方式加以处理.

结构式图片

欧盟法规

ECHA物质ECHA物质C&L通报REACH预注册

上下游产品

methanol dimethyl phenyl phosphate sodium methylate diethyl ether2-Phenoxyethanol (1-bromo-vinyl)-phenyl ether bromo-acetaldehyde diphenylacetal ortho-dimethylaminomethylphenol

合成工艺路线路线简述

    反式-2-十二烯醛,苯酚,钠 以 甲苯 用作溶剂,化学反应 5.0H,以to Obtain A Solution Of 2-Dodecen-1-Ol Sodium Salt And Phenol Sodium Salt的收率获得2-Dodecen-1-Ol Sodium Salt
    参考文献:Resin Composition And Resin Molded Product
    标题:Resin Composition And Resin Molded Product
    摘要:提供的是一种树脂组合物,其中磷氮化合物的侧链中的乙烯基与脂肪族聚酯树脂中的α碳键合.

    海关参考信息

    专利信息


    专利号:US-2024383836-A1
    优先权日:2022-01-28
    标 题:Synthesis of multi-ring disalicylate linkers
    发明人:KAPELEWSKI MATTHEW T; WESTON SIMON C; FALER CATHERINE A
    权利人:EXXONMOBIL TECHNOLOGY & ENGINEERING COMPANY
    摘要:Systems and methods are provided for synthesizing multi-ring disalicylate linkers. The systems and methods can allow for synthesis of disalicylate linkers while using a reduced or minimized amount of solvent (such as down to potentially having no separate solvent) in the reaction environment. The synthesis can be performed by starting with a compound such as 4,4′-biphenol as a starting reagent. The 4,4′-biphenol (and/or other alcohol-substituted biphenyl compound) can then be exposed in a reaction environment to pressurized CO 2 in the presence of a base. The temperature and pressure in the reaction environment can be increased to achieve either supercritical conditions for the CO 2 (based on a phase diagram for neat CO 2 ) and/or sub-critical conditions that are substantially similar to supercritical conditions. This can allow for conversion of the 4,4′-biphenol (or other alcohol-substituted biphenyl compound) into a multi-ring disalicylate linker.

    专利号:US-4751312-A
    优先权日:1984-07-20
    标 题:Process and intermediates for the synthesis of diastereomeric compounds
    发明人:GASTEIGER JOHANN; KAUFMANN KARLHEINZ; MENGEL RUDOLF
    权利人:BAYER AG
    摘要:A new process for the controlled synthesis of the two diasteromeric forms of triazolyl-O,N-acetals of the formula (I) in which R represents optionally substituted phenyl, optionally substituted phenoxy, optionally substituted alkoxy, optionally substituted alkoxy, optionally substituted alkylthio, alkylcarbonyl, nitro or halogen and n represents an integer from 0 to 5, with the proviso that R can represent identical or different radicals, if n represents an integer from 2 to 5. New trans-substituted oxiranes and their use as intermediates for the synthesis of compounds of the formula (I).

    专利号:US-3954709-A
    优先权日:1973-05-29
    标 题:Phenylethyl group containing resins for the synthesis of peptides
    发明人:STEWART JOHN M; MATSUEDA GARY R
    权利人:UNIV COLORADO
    摘要:The phenylethyl group, ##SPC1## n In polymer carriers for the synthesis of peptides and peptide amides, particularly polymer carriers such as styrene-1% divinyl benzene polymers for use in solid phase peptide synthesis. n The invention described herein was made in the course of work under a grant or award from the Department of Health, Education and Welfare.

    专利号:US-5545568-A
    优先权日:1992-09-14
    标题:Solid phase and combinatorial synthesis of compounds on a solid support
    发明人:ELLMAN JONATHAN A
    权利人:UNIV CALIFORNIA
    摘要:Methods, compositions, and devices for synthesizing combinatorial libraries of various useful compounds, such as benzodiazepines, prostaglandins, β-turn mimetics and glycerol-derived drugs is described. In order to expediently synthesize such combinatorial libraries of derivatives based upon these core structures, a general methodology for the solid phase synthesis of these derivatives is also provided. This disclosure thus also describes an important extension of solid phase synthesis methods to nonpolymeric organic compounds.

    专利号:US-4684749-A
    优先权日:1985-05-31
    标 题:Process for the synthesis of phenol
    发明人:PAPARATTO GIUSEPPE
    权利人:MONTEDIPE SPA
    摘要:A process for the synthesis of phenol by means of a hydrolysis of iodobenzene in the liquid phase and in the presence of a Cu containing catalyst, carried out at 120 DEG -260 DEG C. in the presence of a basic acidity acceptor, selected from the group consisting of alkali metal hydroxides and alkali metal salts coming from inorganic or organic acids, showing a pKa equal to or higher than 4.5.

    专利号:US-3972945-A
    优先权日:1974-12-23
    标 题:Process for the selective synthesis of salicylaldehydes
    发明人:ALBRIGHT CHARLES F
    权利人:GARRETT CORP
    摘要:The classical Reimer-Tiemann reaction for the synthesis of phenolic aldehydes has been modified from an aqueous to a non-aqueous system to provide an improved route for the formation of salicylaldehydes and, preferably, 3-substituted salicylaldehydes, e.g. 3-fluorosalicylaldehyde. Heretofore, compounds such as 3-substituted salicylaldehydes have proven to be extremely difficult to prepare in other than small laboratory quantities from the corresponding ortho-substituted phenol, since, in the final salicylaldehyde, each position ortho to the hydroxyl group contains substitution. In particular, with respect to 3-fluorosalicylaldehyde, one of the positions is occupied by the strongly electronegative fluorine atom so that the principal reaction product in the aqueous Reimer-Tiemann reaction has always been the para-isomer (3-fluoro-4-hydroxy-benzaldehyde), only negligible quantities of the desired ortho-isomer being obtained. In the process of the present invention, o-fluorophenol is caused to react with sodium hydroxide and chloroform in a hydrocarbon diluent (preferably benzene), maintaining the reaction under essentially anhydrous conditions by taking up the water of reaction with excess sodium hydroxide. It is necessary that an aprotic solvent, such as N,N-dimethylformamide, be employed as a catalyst. The use of boron oxide, while not absolutely necessary to the reaction, has been found to be advantageous in that the reaction proceeds more smoothly if the phenoxyboroxine is formed initially. The boron oxide also acts as a dehydrating agent and aids in removing the water of reaction. The preferential reaction product is the desired 3-fluorosalicylaldehyde, no paraisomer having been found. After hydrolysis and neutralization, the 3-fluorosalicylaldehyde can be recovered by azeotropic distillation along with a substantial quantity of unreacted o-fluorophenol which can be purified for recycle in subsequent preparations.
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    合成参考文献


    摘要:Weast, R.C. (ed.) Handbook of Chemistry and Physics, 68th ed. Boca Raton, Florida: CRC Press Inc., 1987-1988., p. B-132
    摘要:Lewis, R.J. Sr.; Hawley's Condensed Chemical Dictionary 15th Edition. John Wiley & Sons, Inc. New York, NY 2007., p. 1153
    摘要:U.S. Department of Transportation. 2012 Emergency Response Guidebook. Washington, D.C. 2012
    摘要:Gosselin, R.E., R.P. Smith, H.C. Hodge. Clinical Toxicology of Commercial Products. 5th ed. Baltimore: Williams and Wilkins, 1984., p. III-346
    摘要:Gilman, A.G., L.S.Goodman, and A. Gilman. (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 7th ed. New York: Macmillan Publishing Co., Inc., 1985., p. 970
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