CAS: 305832-67-1; (5-Cyanothiophen-2-yl)Boronic Acid

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CAS号1003-31-2 2-氰基噻吩

2-氰基噻吩置于硼酸三异丙酯,Lithium Hexamethyldisilazane,盐酸体系中,用 四氢呋喃,水 作为反应溶剂,化学反应 0.5H,以89%的收率获得产物5-氰基噻吩-2-硼酸
参考文献:Thio-Oxindole Derivatives
标题:Thio-Oxindole Derivatives
摘要:这项发明涉及激素受体的激动剂化合物,其具有以下一般结构: 其中: R1和r2为h,烷基,取代烷基;oh;o(烷基);o(取代烷基);oac;芳基;取代芳基;杂环芳基;取代杂环芳基;烷基芳基;烷基杂环芳基;1-丙炔基;或3-丙炔基;或r1和r2连接形成烷基,烯基或杂环环;或r1和r2共同包括与cme2形成双键的c(环烷基),O或c(环醚);r3为h,Oh,Nh2,C1至c6烷基,取代c1至c6烷基,C3至c6烯基,炔基,取代炔基,或cora;ra为h,C1至c3烷基,取代c1至c3烷基,C1至c3烷氧基,取代c1至c3烷氧基,C1至c3氨基烷基,或取代c1至c3氨基烷基;r4为h,卤素,Cn,Nh2,No2,C1至c6烷基,或取代c1至c6烷基,C1至c6烷氧基,取代c1至c6烷氧基,C1至c6氨基烷基,或取代c1至c6氨基烷基;r5为可选择取代并选自苯环,具有1,2或3个来自o,S,So,So2或nr6的杂原子的五元或六元杂环环;或吲哚-4-基,吲哚-7-基或苯并-2-噻吩基团;q1为s,Nr7,Cr8R9;或其药学上可接受的盐,以及使用这些化合物诱导避孕或治疗与孕激素相关的癌症和腺癌的方法.

专利信息

专利号:US-2009137557-A1
优先权日:2005-11-22
标题 :Calcilytic Compounds
发明人：KU THOMAS WEN FU; LIN HONG; LUENGO JUAN I; MARQUIS JR ROBERT W; RAMANJULU JOSHI M; TROUT ROBERT; YAMASHITA DENNIS S
权利人:KU THOMAS WEN FU; LIN HONG; LUENGO JUAN I; MARQUIS JR ROBERT W; RAMANJULU JOSHI M; TROUT ROBERT; YAMASHITA DENNIS S
摘要:Novel calcilytic compounds, pharmaceutical compositions, methods of synthesis and methods of using them are provided.

专利号:US-2007275968-A1
优先权日:2004-09-07
标 题 :Substituted Biphenyl Derivative
发明人：KURATA HITOSHI; NISHIMATA TOYOKI; WATANABE YUKIKO; EBISAWA MASAYUKI; FUJIMOTO TEPPEI; KOBAYASHI HIDEKI
权利人:KURATA HITOSHI; NISHIMATA TOYOKI; WATANABE YUKIKO; EBISAWA MASAYUKI; FUJIMOTO TEPPEI; KOBAYASHI HIDEKI
摘要:The present invention relates to a biaryl derivative or a pharmacologically acceptable salt thereof having an excellent collagen-synthesis inhibition activity. A biaryl derivative having a structure represented by the following General Formula (I) or a pharmacologically acceptable salt thereof: n nwherein n R 1 represents a C 6 -C 10 aryl group which is substituted with one to three group(s) each independently selected from the group consisting of a group defined by formula R-L-, a di-(C 1 -C 6 alkyl)amino group, a di-(C 1 -C 6 alkyl)aminosulfonyl group, a hydroxyaminocarbonyl group, and a halogen atom, and so on; R represents a C 1 -C 6 alkyl group, and so on; L represents a sulfonyl group, an aminosulfonyl group, or a sulfonylamino group, and so on; R 2 represents a hydrogen atom, and so on; A represents a group defined by formula (II), (III), or (IV); R 3 represents a C 1 -C 6 alkyl group, and so on; and R 4 represents a C 1 -C 6 alkyl group, and so on.