专利号:US-7714063-B2 优先权日:2007-11-15 标 题 :Solid support for Fmoc-solid phase synthesis of peptides 发明人:SRIVASTAVA KRIPA SHANKER; DAVIS MATTHEW RYAN 权利人:MALLINCKRODT INC 摘要:The present invention provides compositions and processes for the solid phase synthesis of polypeptides. In particular, the present invention provides solid supports and processes for preparing solid supports for the synthesis of polypeptides.
专利号:WO-2014175623-A1 优先权日:2013-04-26 标 题 :Novel tubulin polymerization inhibitor and method for synthesizing same 发明人:KIM BO YEON; N R THIMMEGOWDA; KIM SUN OK; SOUNG NAK KYUN; SAKCHAISRI KRISADA; RYOO INJA; PARK CHAN-MI; AHN JONG SEOG; JANG JAE-HYUK 权利人:KOREA RES INST OF BIOSCIENCE 摘要:The present invention relates to (E)-ethyl 2-(2-methyl-3-((2-(naphtho[2,1-b]furan-2-carbonyl)hydrazono)methyl)-1H-indol-1-yl)acetate as a novel tubulin polymerization inhibitor and a method for synthesizing the same. The compound of the present invention can inhibit mitosis and induce apoptosis and thus be used as an anticancer agent, by binding to tubulin to inhibit microtube polymerization. According to the synthesis method of the present invention, the reaction is simplified and the efficiency is 60% or higher, leading to a very high yield, thereby providing an effective synthesis method.
专利号:EP-3515880-B1 优先权日:2017-03-17 标题:Methods and compositions for synthesis of encoded libraries 发明人:LI JIN; MORGAN BARRY A; Wan jinqiao; DOU DENGFENG; LIU GUANSAI; CHANG YONG; CHEN QIUXIA; WANG XING; XU YANSHAN; HU DONGYAN; LIU JIAN; CHENG XUEMIN 权利人:HITGEN INC
专利号:US-2020149034-A1 优先权日:2017-03-17 标题:Methods and Compositions for Synthesis of Encoded Libraries
专利号:US-2009131587-A1 优先权日:2007-11-15 标题:Solid Support for Fmoc-Solid Phase Synthesis of Peptides
专利号:WO-0050406-A1 优先权日:1999-02-22 标 题 :Isoquinoline derivatives and isoquinoline combinatorial libraries 发明人:LEBL MICHAEL 权利人:TREGA BIOSCIENCES INC 摘要:The present invention provides the synthesis of heterocyclic compounds based on the isoquinoline ring. More specifically, the invention provides novel isoquinoline derivatives as well as novel libraries comprised of such compouds.
[参考文献]: Ming-Zhi Zhang, Et Al. Synthesis And Antifungal Activity Of Novel Streptochlorin Analogues. Eur J Med Chem. 2015 Mar 6:92:776-83. [参考文献]: Xingkuan Chen, Et Al. Functionalization Of Benzylic C(Sp(3))-H Bonds Of Heteroaryl Aldehydes Through N-Heterocyclic Carbene Organocatalysis. Angew Chem Int Ed Engl. 2013 Oct 11;52(42):11134-7.
合成参考文献
摘要:Joule, J. A., Science of Synthesis Knowledge Updates, (2010) 2, 244. 摘要:Harris, P. A., Science of Synthesis Knowledge Updates, (2021) 3, 31. 摘要:F. Terrier, F. Millot and R. Schaal, Bull. Soc. Chim. Fr. 1969, 3003.