在 Fluorophores体系中,化学反应生成 联苯酸酐 参考文献:Steinfatt,Manfred F.D.,Journal Of Chemical Research,Miniprint,1984,# 4,P. 1040-1062 标题:Steinfatt,Manfred F.D.,Journal Of Chemical Research,Miniprint,1984,# 4,P. 1040-1062
专利号:US-6469065-B1 优先权日:1996-02-02 标 题:Nitrosated and nitrosylated α-adrenergic receptor antagonist, compositions and methods of use 发明人:GARVEY DAVID S; SCHROEDER JOSEPH D; DE TEJADA INIGO SAENEZ; GASTON RICKY D; SHELEKHIN TATIANA E; WANG TIANSHENG 权利人:NITROMED INC 摘要:The present invention describes novel nitrosated and/or nitrosylated α-adrenergic receptor antagonists, and novel compositions containing at least one nitrosated and/or nitrosylated α-adrenergic receptor antagonist, and, optionally, one or more compounds that donate, transfer or release nitric oxide, elevate endogenous levels of endothelium-derived relaxing factor, stimulate endogenous synthesis of nitric oxide or are a substrate for nitric oxide synthase, and/or one or more vasoactive agents. The present invention also provides novel compositions containing at least one α-adrenergic receptor antagonist, and one or more compounds that donate, transfer or release nitric oxide, elevate endogenous levels of endothelium-derived relaxing factor, stimulate endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or one or more vasoactive agents. The present invention also provides methods for treating or preventing sexual dysfunctions in males and females, for enhancing sexual responses in males and females, and for treating or preventing benign prostatic hyperplasia, hypertension, congestive heart failure, variant (Printzmetal) angina, glaucoma, neurodegenerative disorders, vasospastic diseases, cognitive disorders, urge incontinence, or overactive bladder, and for reversing the state of anesthesia.
专利号:US-8017323-B2 优先权日:2003-03-26 标 题 :Free reactant use in nucleic acid-templated synthesis 发明人:LIU DAVID R; SAKURAI KAORI 权利人:HARVARD COLLEGE 摘要:The present invention provides methods and compositions for expanding the scope of chemical reactions that can be performed during nucleic acid-templated organic syntheses. In particular, nucleic acid-templated chemistries are used to produce reaction intermediates attached to an oligonucleotide that can be used to identify the reaction intermediates and/or the resulting reaction products. The reaction intermediates then are reacted with free reactants (for example, reactants that are difficult or impractical to couple to an oligonucleotide) to produce a reaction product. This approach expands the scope of reagents useful in nucleic acid-templated syntheses to reagents that do not need to be or cannot be tethered to an oligonucleotide. The reagents, however, still permit the synthesis of reaction products attached to oligonucleotides that can be used to identify the reaction products.
专利号:US-2005187222-A1 优先权日:1996-02-02 标题:Nitrosated and nitrosylated alpha-adrenergic receptor antagonist compounds 发明人:GARVEY DAVID S; DE TEJADA INIGO S; GASTON RICKY D; KHANAPURE SUBHASH P; SHELEKHIN TATIANA E; WANG TIANSHENG 权利人:NITROMED INC 摘要:The present invention describes novel nitrosated and/or nitrosylated α-adrenergic receptor antagonists, and novel compositions containing at least one nitrosated and/or nitrosylated α-adrenergic receptor antagonist, and, optionally, one or more compounds that donate, transfer or release nitric oxide, elevate endogenous levels of endothelium-derived relaxing factor, stimulate endogenous synthesis of nitric oxide or are a substrate for nitric oxide synthase, and/or one or more vasoactive agents. The present invention also provides novel compositions containing at least one α-adrenergic receptor antagonist, and one or more compounds that donate, transfer or release nitric oxide, elevate endogenous levels of endothelium-derived relaxing factor, stimulate endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or one or more vasoactive agents. The present invention also provides methods for treating or preventing sexual dysfunctions in males and females, for enhancing sexual responses in males and females, and for treating or preventing benign prostatic hyperplasia, hypertension, congestive heart failure, variant (Printzmetal) angina, glaucoma, neurodegenerative disorders, vasospastic diseases, cognitive disorders, urge incontinence, or overactive bladder, and for reversing the state of anesthesia.
专利号:US-4786755-A 优先权日:1985-06-03 标题 :Diphenic acid monoamides 发明人:KIELY JOHN S; HUANG SUCHIN 权利人:WARNER LAMBERT CO 摘要:The present invention provides various novel diphenic acid monoamide compounds, novel pharmaceutical compositions and methods of use thereof, as well as novel methods of synthesis therefor. The novel diphenic acid monoamides of the present invention are leukotriene antagonists, 5-lipoxygenase inhibitors, and mediator release inhibitors providing activity useful for treating asthma, allergies, cardiovascular diseases, migraines, and immunoinflammatory conditions.
专利号:US-4602023-A 优先权日:1985-06-03 标题 :Diphenic acid monoamides 发明人:KIELY JOHN S; HUANG SUCHIN 权利人:WARNER LAMBERT CO 摘要:The present invention provides various novel diphenic acid monoamide compounds, novel pharmaceutical compositions and methods of use thereof, as well as novel methods of synthesis therefor. The novel diphenic acid monoamides of the present invention are leukotriene antagonists, 5-lipoxygenase inhibitors, and mediator release inhibitors providing activity useful for treating asthma, allergies, cardiovascular diseases, migraines, and immunoinflammatory conditions.
参考标题:Room-Temperature Synthesis Of Pharmaceutically Important Carboxylic Acids Bearing The 1,2,4-Oxadiazole Moiety 作者:Marina Tarasenko,Nikolay Duderin,Tatyana Sharonova,Sergey Baykov,Anton Shetnev,Alexey V. Smirnov |发布日期:2017.9 摘要:An Efficient And Mild One-Pot Protocol Has Been Developed For The Synthesis Of 1,2,4-Oxadiazoles Via The Reaction Of Amidoximes With Dicarboxylic Acid Anhydrides In A Naoh/dmso Medium. The Method Allows The Synthesis Of Diversely Substituted Carboxylic Acids Bearing The 1,2,4-Oxadiazole Motif, - A Popular Building Block For Pharmaceutical Research, In Moderate To Excellent Yields. The Reaction Scope
合成参考文献
参考文献:10.1002/jssc.200900723 摘要:Micó‐Tormos A, Simó‐Alfonso EF, Ramis‐Ramos G. Single‐pump bi‐dimensional LC applied to the characterization of derivatized fatty alcohol ethoxylates. J of Separation Science. 2010 May 19;33(10):1398–404. doi: 10.1002/jssc.200900723.