CAS: 700-00-5; 9-Methyl-9H-Purin-6-Amine

上下游产品

6-chloro-9-methyl-9H-purine 2-Chloro-9-methyladenine 7H-purin-6-ylamine methyl iodide 6-Phenyl-9-methyladenineN6-Phenyl-9-methyladenine 9-methyl-6-phenyl-9H-purine H-purin-6-ylamine9-methyl-1-oxy-9H-purin-6-ylamine 9-methylhypoxanthine

Ethyl N-(4-Cyano-1-Methyl-1H-Imidazol-5-yl)Formimidate置于氨体系中,用 甲醇 作为反应溶剂,化学反应 1.0H,以87%的收率获得产物9-甲基腺嘌呤
参考文献:主体(β沸石)-客体(铜(II)-甲基腺嘌呤配合物)纳米材料:合成与表征
标题:主体(β沸石)-客体(铜(II)-甲基腺嘌呤配合物)纳米材料:合成与表征
摘要:来宾铜(II)-甲基腺嘌呤络合物被截留在β中沸石 (bea)作为主体,方法是依次引入液相中的各组分,然后 部件 在空隙的内部 沸石.测试版沸石是用原始技术准备的.选择用于原位复合物合成的合适方法是使用9-甲基腺嘌呤 配体:铜(II)的摩尔比为4:1.索氏提取.东亚银行沸石铜(II)-甲基腺嘌呤配合物的特征在于几种技术:扫描电镜 和 X射线衍射,化学分析(ca),光谱法(电子病历,红外光谱,紫外可见 和 Xps) 和 Tga(热分析).数据分析表明,客体铜(II)配合物被有效地固定在bea中,而其形态和结构没有任何改变.沸石.的协调9-甲基腺嘌呤 配体在主体纳米材料中以铜(II)离子作为客体以优选的1:1化学计量比获得.
DOI:10.1039/b807904H

专利信息

专利号:US-10730904-B2
优先权日:2012-11-14
标 题:Method for liquid-phase synthesis of nucleic acid
发明人：NONOGAWA MITSURU; NAGATA TOSHIAKI; SAITO HIDEKI; YASUMA TSUNEO
权利人:TAKEDA PHARMACEUTICALS CO
摘要:In this method, an oligonucleotide represented by formula (II) [wherein Y 1 , Q, Base, r and r′ are each as defined in claim 1 ] is prepared by using, as a synthesis unit, a novel nucleoside monomer compound represented by formula (I) [wherein X, R 1 , Y, Base, Z, Ar, R 2 , R 3 and n are each as defined in claim 1 ]. The novel nucleoside monomer compound is a nucleoside, the base moiety of which is substituted with an aromatic-hydrocarbon-ring-carbonyl or -thiocarbonyl group having at least one hydrophobic group. The method can dispense with column-chromatographic purification in every reaction, and enables base elongation not only in the 3′-direction but also in the 5′-direction, thus attaining efficient liquid-phase mass synthesis of an oligonucleotide.

专利号:US-6040439-A
优先权日:1997-09-05
标题 :Method for chemical synthesis of oligonucleotides
发明人：HAYAKAWA YOSHIHIRO; KATAOKA MASANORI
权利人:JAPAN SCIENCE & TECH CORP
摘要:The present invention provides a practical method capable of chemically synthesizing a 100-mer or more long-chain oligonucleotide easily and reliably and a novel compound used in said method. The present invention relates to a method for chemical synthesis of an oligonucleotide by the phosphoroamidite method, which comprises preparing a base moiety-unprotected nucleoside phosphoroamidite from a base moiety-unprotected nucleoside by use of an imidazole trifluoromethanesulfonate represented by the following chemical formula, and coupling said base moiety-unprotected nucleotide phosphoroamidite in a predetermined order to chemically synthesize an oligonucleotide consisting of a specific nucleotide sequence, as well as to an imidazole trifluoromethanesulfonate represented by the chemical formula. ##STR1##

专利号:US-7122693-B2
优先权日:1988-04-11
标题 :Acetaldehyde acetal compounds, their synthesis, and uses thereof
发明人：BELLEAU EXECUTRIX OF ESTATE PI; DIXIT DILIP M; NGUYEN-BA NGHE
权利人:SHIRE BIOCHEM INC
摘要:The acetaldehyde compounds, 2-thiobenzoylacetaldehyde diethylacetal, 2-benzoyloxyacetaldehyde bis(2-methoxyethyl)acetal, 2-hydroxyacetaldehyde bis( 2-methoxyethyl)acetal, 2-thiobenzoylacetaldehyde bis(2-methoxy-ethyl)acetal, and 2-thioacetaldehyde bis(2-methoxyethyl)acetal, are useful as intermediates in the synthesis of substituted 1,3-oxathiolanes and substituted 1,3-dioxolanes.

专利号:US-2023212204-A1
优先权日:2020-01-16
标题:Reagents and their use for modular enantiodivergent synthesis of c-p bonds
发明人：XU DONGMIN; RIVAS-BASCÓN NAZARET; KNOUSE KYLE W; PADIAL NATALIA; ZHENG BIN; VANTOUROUT JULIEN; SCHMIDT MICHAEL; EASTGATE MARTIN D; BARAN PHI
权利人:BRISTOL MYERS SQUIBB CO; SCRIPPS RESEARCH INST
摘要:The disclosure describes chiral P(V)-based reagents and their uses for the modular, scalable, and stereospecific synthesis of chiral phosphines, phosphine oxides and particular oligonucleotides.

专利号:US-2008206850-A1
优先权日:2007-02-28
标 题:Methods and compositions for DNA synthesis
发明人：DELLINGER DOUGLAS J; DELLINGER GERALDINE F; CARUTHERS MARVIN H
权利人:DELLINGER DOUGLAS J; DELLINGER GERALDINE F; CARUTHERS MARVIN H
摘要:In some embodiments, the present disclosure relates to new phosphoramidite compositions, that have Silyl-containing carbonate or thiocarbonate or ether as 5′-hydroxyl protecting groups useful of the synthesis of DNA, and in particular for the synthesis of long sequences of DNA (e.g., >50 mer). In some embodiments, there are provided methods for simultaneous oxidation of the internucleoside phosphate triester linkages and removal of the 5′-hydroxyl-protecting group, making this process a new 2-step DNA synthesis, that involves the use of peroxyanions in combination with fluoride anions.

专利号:US-2008206851-A1
优先权日:2007-02-28
标题:Methods and compositions for RNA synthesis
发明人：DELLINGER DOUGLAS J; DELLINGER GERALDINE F; CARUTHERS MARVIN H
权利人:DELLINGER DOUGLAS J; DELLINGER GERALDINE F; CARUTHERS MARVIN H
摘要:In some embodiments, the present disclosure relates to new phosphoramidite compositions, that have Silyl-containing carbonate or thiocarbonate or ether as 5′-hydroxyl protecting groups useful fo the syntheis of RNA, and in particular for the synthesis of long sequences of RNA (e.g., >50 mer). In some embodiments, there are provided methods for simultaneous oxidation of the internucleoside phosphate triester linkages and removal of the 5′-hydroxyl-protecting group, making this process a new 2-step RNA synthesis, that involves the use of peroxyanions in combination with fluoride anions.