CAS: 86347-14-0; 4-(1-(2,3-Dimethylphenyl)Ethyl)-1H-Imidazole

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CAS号86347-15-1 盐酸美托咪啶 | CAS号60907-90-6 1-(2,3-二甲基苯基)乙醇 | CAS号18156-74-6 三甲基硅咪唑(TSIM) | CAS号576-23-8 3-溴邻二甲苯 | CAS号176721-02-1 (2,3-二甲基苯基)(1-三... | CAS号176721-01-0 ALPHA-(2,3-二甲基苯... | CAS号603-79-2 2,3-二甲基苯甲酸 | CAS号21900-46-9 2,3-二甲基苯甲酰氯 | CAS号86347-15-1 盐酸美托咪啶

(2-(2,3-Xylyl)-2-Propanol)置于盐酸,4-二甲氨基吡啶,Ammonium Hydroxide,5,5-二溴巴比妥酸,3% Pd/c,三乙胺,三氯氧磷体系中,用 四氢呋喃,乙醇,水,甲苯 作为反应溶剂,20.0~120.0 °C,500.01 Kpa 条件下,反应 33.5H,反应生成 美托咪定
参考文献: Processes For The Preparation Of Compounds,Such As 3-Arylbutanals,Useful In The Synthesis Of Medetomidine[fr] Procédés Pour La Préparation De Composés,Tels Que 3-Arylbutanals,Utiles Dans La Synthèse De Médétomidine
标题: Processes For The Preparation Of Compounds,Such As 3-Arylbutanals,Useful In The Synthesis Of Medetomidine[fr] Procédés Pour La Préparation De Composés,Tels Que 3-Arylbutanals,Utiles Dans La Synthèse De Médétomidine
摘要:提供一种制备式(i)化合物的方法,其中该方法包括将式(II)化合物与一种或多种适当的vilsmeier试剂反应,如本文所定义.

专利信息

专利号:US-6867202-B1
优先权日:1997-06-25
标 题 :Treatment of insulin resistance
发明人：CARPINO PHILIP ALBERT; CHIU CHARLES KWOK-FUNG; PAN LYDIA CODETTA; LEFKER BRUCE ALLEN; TREADWAY JUDITH LEE; ZAWISTOSKI MICHAEL PAUL
权利人:PFIZER
摘要:This invention is directed to methods of treating insulin resistance in a mammal which comprise administering an effective amount of a compound of formula I, n n nwhere the variables are defined in the specification, or the stereoisomeric mixtures, diastereomerically enriched, diastereomerically pure, enantiomerically enriched or enantiomerically pure isomers, or the pharmaceutically acceptable salts and prodrugs thereof to said mammal. The compounds of formula I are growth hormone secretagogues and as such are useful for increasing the level of endogenous growth hormone. In another aspect this invention provides certain intermediates which are useful in the synthesis of the foregoing compounds and certain processes useful for the synthesis of said intermediates and th compounds of formula I. This invention is further directed to methods comprising administering to a human or other animal a combination of a functional somatostatin antagonist such as an alpha-2 adrenergic agonist and a compound of formula I.

专利号:US-10053420-B2
优先权日:2015-01-30
标 题 :Processes for the preparation of compounds, such as 3-arylbutanals, useful in the synthesis of medetomidine
发明人：EKLUND LARS; EEK MARGUS; EKAMBARAM RAMESH; MAASALU ANTS
权利人:CAMBREX KARLSKOGA AB
摘要:There is provided a process for the preparation of a compound of formula (I) as defined herein, wherein said process comprises reacting a compound of formula (II) as defined s herein with one or more suitable Vilsmeier reagent.

专利号:US-RE41998-E
优先权日:1990-02-26
标题 :Compositions and methods of treatment of sympathetically maintained pain
发明人：CAMPBELL JAMES N
权利人:ARCLON THERAPEUTICS INC
摘要:Sympathetically maintained pain is treated topically by administering to the site where sympathetically maintained pain is present an α-1-adrenergic antagonist, α-2-adrenergic agonist, or other drug that depletes or blocks synthesis of sympathetic norepinephrine, known collectively as sympatholytic agents. Chemical formulas for several sympatholytic agents are given.

专利号:US-2019314312-A1
优先权日:2016-07-11
标题 :Combination therapy to increase endogenous nitric oxide (no) synthesis
发明人：EREZ AYELET; STETTNER NOA
权利人:YEDA RES & DEV
摘要:Provided are uses of a therapeutically effective amount of citrulline for the manufacture of a medicament for treatment of a subject having an inflammatory bowel disease (IBD) and/or colon cancer. Also provided are pharmaceutical compositions comprising a therapeutic effective amount of citrulline and a therapeutically effective amount of a flavonoid for the treatment of an inflammatory bowel disease (IBD) and/or colon cancer and kits comprising same.

专利号:US-7749985-B2
优先权日:2006-09-15
标 题 :Acyloxyalkyl carbamate prodrugs, methods of synthesis and use
发明人：GALLOP MARK A; XU FENG; PHAN THU; DILIP USHA; PENG GE
权利人:XENOPORT INC
摘要:Acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, methods of making acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, methods of using acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, and pharmaceutical compositions comprising acyloxyalkyl carbamate prodrugs 3-aminopropylphosphinic acid and analogs thereof for treating diseases or disorders such as mild cognitive impairment, cognitive impairment associated with Alzheimer's disease Alzheimer's disease, depression, anxiety, and epilepsy are disclosed. Acyloxyalkyl carbamate prodrugs of 3-aminopropylphosphinic acid and analogs thereof, which are suitable for oral administration and sustained release oral dosage forms are also disclosed.

专利号:US-2012015923-A1
优先权日:2009-03-24
标 题:Use of andrographolide compounds for treating inflammation and airway disorders
发明人：WONG WAI SHIU FRED
权利人:WONG WAI SHIU FRED; UNIV SINGAPORE
摘要:We describe for the first time that andrographolide derivatives such as DDAG effectively reduced OVA-induced inflammatory cell recruitment into BAL fluid, IL-4, IL-5, IL-13 and eotaxin production, serum IgE synthesis, pulmonary eosinophilia, mucus hypersecretion and AHR in a mouse asthma model potentially via inhibition of NF-?B activity. Moreover, low dose of DDAG and glucocorticoid combination treatment synergistically attenuate inflammation in mouse asthma model. These findings support a therapeutic value for DDAG in the treatment of asthma.