CAS: 1256490-52-4; (2S)-Isopropyl 2-(((Perfluorophenoxy)(Phenoxy)Phosphoryl)Amino)Propanoate

相似化合物

1627824-09-2 1334513-02-8 1337529-56-2

上下游产品

2,3,4,5,6-pentafluorophenol O-phenyl phosphorodichloridate alanine isopropyl ester hydr°Chloride phenyl(isopropoxy-L-alaninyl) phosphor°Chloridatesofosbuvir 22H32N5O8PC22H32N5O8P (2S)-isopropyl 2-(((((2R,3S,4R,5R)-4-amino-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)amino)propanoate 23H30N3O10PC23H30N3O10P

二氯磷酸苯酯置于三乙胺体系中,用 乙酸乙酯 用作溶剂,化学反应 3.5H,反应生成索非布韦中间体
参考文献: 2'-Substituted-N6-Substituted Purine Nucleotides For Rna Virus Treatment[fr] Nucléotides De Purine Substitués En Position 2'-N 6 Pour Le Traitement Du Virus à Arn
标题: 2'-Substituted-N6-Substituted Purine Nucleotides For Rna Virus Treatment[fr] Nucléotides De Purine Substitués En Position 2'-N 6 Pour Le Traitement Du Virus à Arn
摘要:描述的化合物或其药用盐或组合物的使用,用于治疗感染了除hcv之外的rna病毒或其他在本文中更详细描述的疾病.

专利信息

专利号:US-10112967-B2
优先权日:2016-02-25
标 题:Process for the preparation of sofosbuvir
发明人：GABOARDI MAURO; PALLANZA GIUSEPPE; BARATELLA MARCO; CASTALDI GRAZIANO; CASTALDI MARTA
权利人:HC PHARMA AG
摘要:A process for the synthesis of Sofosbuvir n nis provided comprising the steps of selectively mono-deacetylating a compound of formula (V)n n nenzymatically using a resin supported lipase B derived from Candida Antarctica to obtain a compound formula (IV),n n nthen converting the compound of formula (IV) to a compound of formula (II)n n nby reacting the compound of formula (IV) with a compound of formula (III), andn n nthen converting the compound of formula (II) to Sofosbuvir of formula (I) by deacetylation reaction.

专利号:US-10100075-B2
优先权日:2013-12-23
标 题:Process for the preparation of sofosbuvir
发明人：KAUSHIK VIPIN KUMAR; RAVI VIJAYA KRISHNA; VAKITI SRINIVAS; TIRUMALARAJU BHAVANISANKAR
权利人:MYLAN LABORATORIES LTD; MYLAN LABORATORIES LTD
摘要:The present disclosure relates to processes for the preparation of sofosbuvir or of its pharmaceutically acceptable salts. The present disclosure also provides intermediates useful in the synthesis of sofosbuvir.

专利号:US-10344009-B2
优先权日:2015-11-03
标题 :Process for the preparation of sofosbuvir
发明人：JAYACHANDRA SURESHBABU; KAUSHIK VIPIN KUMAR; RAVI VIJAYA KRISHNA; DEV VIKAS CHANDRA; KOTTOLLA SAIPRASAD; RAO POTLA VENKATA SRINIVASA; VAKITI SRINIVAS; MUGGU CHAITANYA; DANDALA SUBRAMANYAM
权利人:MYLAN LABORATORIES LTD
摘要:A process for the preparation of intermediates 9, useful in the synthesis of sofosbuvir, as well as intermediates of formula [12] are disclosed herein.

专利号:US-2011245484-A1
优先权日:2010-03-31
标 题 :Stereoselective synthesis of phosphorus containing actives

专利号:WO-2011123668-A2
优先权日:2010-03-31
标 题:Stereoselective synthesis of phosphorus containing actives

专利号:EP-2752422-A1
优先权日:2010-03-31
标 题 :Stereoselective synthesis of phosphorus containing actives