专利号:US-6531591-B1 优先权日:1999-07-07 标 题 :Synthesis of stable quinone and photoreactive ketone phosphoramidite reagents for solid phase synthesis of photoreactive-oligomer conjugates 发明人:FENSHOLDT JEF 权利人:EXIQON AS 摘要:Quinone phosphoramidite reagents as well as photoreactive ketone phosphoramidite reagents, such as anthraquinone phosphoramidite reagents and benzophenone phosphoramidite reagents were synthesized and used for the solid phase synthesis of photoreactive-oligonucleotide conjugates. These phosphoramidite reagents are stable, suitable for large-scale synthesis and designed for automated solid phase synthesis of oligomers terminating in a photoreactive moiety.
专利号:EP-1202998-B1 优先权日:1999-07-07 标 题 :Synthesis of stable quinone and photoreactive ketone phosphoramidite reagents for solid phase synthesis of photoreactive-oligomer conjugates 发明人:FENSHOLDT JEF 权利人:EXIQON AS 摘要:Quinone phosphoramidite reagents as well as photoreactive ketone phosphoramidite reagents, such as anthraquinone phosphoramidite reagents and benzophenone phosphoramidite reagents were synthesized and used for the solid phase synthesis of photoreactive-oligonucleotide conjugates. These phosphoramidite reagents are stable, suitable for large-scale synthesis and designed for automated solid phase synthesis of oligomers terminating in a photoreactive moiety.
专利号:US-5424421-A 优先权日:1990-07-17 标 题:Synthesis of carminic acid and principal intermediates 发明人:TYMAN JOHN H P; FIECCHI ALBERTO 权利人:EUROP COLOUR PLC 摘要:The invention relates to the synthesis of 6-deoxykermesates, 6-deoxykermesic acid, and carminic acid, based on a reaction of a 2-halogenonapthazarin with a bis-trimethylsilyl-diene.
专利号:US-2022378721-A1 优先权日:2019-10-24 标 题 :Protein kinase inhibitors and use thereof for treatment of neurodegenerative diseases 发明人:SRIDHAR JAYALAKSHMI; BRATTON MELYSSA; GOYAL NAVNEET; JHA VISHWAJEET; SCHROEDER RICHARD 权利人:XAVIER UNIV OF LOUISIANA 摘要:The present disclosure relates to compounds that act as protein kinase inhibitors, especially CK1δ and/or CK1ε inhibitors, which can be used to treat a serine threonine kinase-dependent disease and condition, such as neurodegenerative diseases like Alzheimer's Disease, and the synthesis of the same. Further, the present disclosure teaches the utilization of such compounds in a treatment for neurodegenerative diseases, including Alzheimer's disease.
专利号:US-4739062-A 优先权日:1985-07-09 标题:Method of producing paraquinones 发明人:BIGI FRANCA; CASIRAGHI GIOVANNI; CASNATI GIUSEPPE; SARTORI GIOVANNI 权利人:CONSIGLIO NAZIONALE RICERCHE 摘要:A new widely-applicable method has been found for synthesis of 9,10-anthraquinones and similar chemical compounds of wide use in industry and pharmacology, by reacting suitable aromatic substrates with activated dicarboxylic acids (more particularly dichlorides) in the presence of metal halides. The special characteristics of the reaction are the good yields, high selectivity, the possibility of operating in a single reactor and the use of starting compounds which are cheap and easily available on the market.
专利号:WO-2005059046-A1 优先权日:2003-12-10 标 题:Improved process for the production of printing inks 发明人:NIVEN STUART COOK; WILCOX JOYCE 权利人:CIBA SC HOLDING AG; NIVEN STUART COOK; WILCOX JOYCE 摘要:Process for preparing a polar organic solvent-based printing ink composition which comprises reacting a dye precursor of a cationic indole dye with an organic non-abietyl resin acid, preferably an organic sulfonic acid, in a polar organic solvent suitable for printing inks or in the printing ink medium. The synthesis of the coloured ink via an in-situ generation of the cationic dye offers many procedural advantages such the avoidance of isolation and purification steps for the dye. The printing inks obtained show for example high colour strength and excellent rheological properties and can be used in publication or packaging gravure flexographic, lithographic or letterpress printing processes.
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