CAS: 1423-26-3; (3-(Trifluoromethyl)Phenyl)Boronic Acid

上下游产品

3-(trifluoromethyl)phenyllithium α,α,α-trifluorotoluene bis(pinacol)diborane 3-bromo-1-trifluoromethylbenzene 3-Trifluormethyl-phenylborsaeure-bis-trimethylsilylester 3'-(trifluoromethyl)-[1,1'-biphenyl]-4-carboxylic acid 4-(3-trifluoromethylphenyl)anisole 3'-(trifluoromethyl)[1,1'-biphenyl]-4-ol

3-(三氟甲基)苯硼酸频哪醇酯置于水体系中,用 1,2-二氯乙烷 用作溶剂,化学反应 12.0H,反应生成3-(三氟甲基)苯硼酸
参考文献:芳硼酸催化喹啉还原烷基化为n-烷基四氢喹啉
标题:芳硼酸催化喹啉还原烷基化为n-烷基四氢喹啉
摘要:已经证明了硼酸催化喹啉单锅串联还原为四氢喹啉,然后通过醛还原烷基化.N-烷基四氢喹啉的这种步骤经济的合成方法是在温和的反应条件下,从容易获得的喹啉,醛和汉茨酯直接完成的.机理研究证明了有机硼催化剂作为路易斯酸和氢键供体的独特行为.
Doi:10.1021/acs.Orglett.1C00302

专利信息

专利号:US-12150934-B2
优先权日:2016-11-30
标 题 :Methods of using substituted pyrazole and pyrazole compounds and for treatment of hyperproliferative diseases
发明人：SIDDIQUI ARSHAD M; CIBLAT STEPHANE; CONSTANTINEAU-FORGET LEA; GRAND-MAITRE CHANTAL; GUO XIANGYU; SRIVASTAVA SANJAY; SHIPPS GERALD W; COOPER ALAN B; OZA VIBHA; KOSTURA MATTHEW W; LUTHER MICHAEL; LEVINE JEDD
权利人:BANTAM PHARMACEUTICAL LLC
摘要:Disclosed are methods of treating hyperproliferative disorders such as cancer, methods of arresting the cell cycle in cancer cells, methods of inhibiting glutathione synthesis in cancer cells, and associated compounds for use and uses in medicaments. In certain embodiments, the methods, uses and compounds are provided with reference to compounds of the structural formula (I), in which X1, X2, Z1, Z2, the ring system denoted by “aâ€?, R1, L1, L2, Q, L3, R3, L4, R4, L5, and R5 are as described herein. In certain embodiments, compounds disclosed herein are especially active against cancers having a mutant KRAS gene.

专利号:US-11066447-B2
优先权日:2016-08-08
标 题:Aureobasidium derivatives and methods of synthesis
发明人：WUTS PETER; ELHAMMER AKE P
权利人:AUREOGEN BIOSCIENCES INC; AUEROGEN BIOSCIENCES INC
摘要:In general, the invention relates to AbA derivatives that are useful for treating infection. These novel compounds are shown to be effective in treating various fungal infections. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various fungal infections.

专利号:US-2011021532-A1
优先权日:2008-04-22
标题 :Novel substituted heteroaromatic compounds as inhibitors of stearoyl-coenzyme a delta-9 desaturase
发明人：POWELL DAVID; LEBRUN MARIE-EVE; BHAT SATHESH; RAMTOHUL YEEMAN K
权利人:MERCK FROSST CANADA LTD
摘要:Substituted heteroaromatic compounds of structural formula I are inhibitors of stearoyl-coenzyme A delta-9 desaturase. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; Type 2 diabetes; insulin resistance; hyperglycemia; Metabolic Syndrome; neurological disease; cancer; and liver steatosis. Formula (I).

专利号:US-7250410-B2
优先权日:2001-06-07
标题:Cyclic nucleotide phosphodiesterase inhibitors, preparation and uses thereof
发明人：BOURGUIGNON JEAN-JACQUES; LAGOUGE YAN; LUGNIER CLAIRE; KLOTZ EVELINE; MACHER JEAN-PAUL; RABOISSON PIERRE; SCHULTZ DOMINIQUE
权利人:VIA PHARMACEUTICALS INC
摘要:The invention concerns novel benzodiazepine derivatives and their uses in the field of therapeutics particularly for treating pathologies involving the activity of a cyclic nucleotide phosphodiesterase. It also concerns methods for preparing them and novel synthesis intermediates. The inventive compounds more particularly correspond to general formula (I):

专利号:US-2009137557-A1
优先权日:2005-11-22
标题 :Calcilytic Compounds
发明人：KU THOMAS WEN FU; LIN HONG; LUENGO JUAN I; MARQUIS JR ROBERT W; RAMANJULU JOSHI M; TROUT ROBERT; YAMASHITA DENNIS S
权利人:KU THOMAS WEN FU; LIN HONG; LUENGO JUAN I; MARQUIS JR ROBERT W; RAMANJULU JOSHI M; TROUT ROBERT; YAMASHITA DENNIS S
摘要:Novel calcilytic compounds, pharmaceutical compositions, methods of synthesis and methods of using them are provided.

专利号:WO-2018031521-A1
优先权日:2016-08-08
标 题:Aureobasidium derivatives and methods of synthesis