CAS: 23214-92-8; 5,12-Naphthacenedione, 10-[(3-Amino-2,3,6-Trideoxy-α-L-Lyxo-Hexopyranosyl)Oxy]-7,8,9,10-Tetrahydro-6,8,11-Trihydroxy-8-(2-Hydroxyacetyl)-1-Methoxy-, (8S,10S)-

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CAS号25316-40-9 盐酸阿霉素 | CAS号1231872-23-3 Ser-Leu-PABC-Do... | CAS号54193-28-1 阿霉素醇 | CAS号791111-74-5 N-[Nα-(9-fluore... | CAS号791111-75-6 [ValPro]-[doxor... | CAS号1353003-29-8 | CAS号188530-64-5 Doxo-MBS | CAS号26295-56-7 N-三氟乙酰基阿霉素 | CAS号24385-10-2 阿霉酮 | CAS号114390-31-7 aconityldoxorubicin | CAS号76634-99-6 5,12-Naphthacen... | CAS号80242-51-9 2,2,3,3,3-penta...

道诺霉素置于cytochrome P450 Monoxygenase Doxa体系中,化学反应生成阿霉素
参考文献:Understanding Of Real Alternative Redox Partner Of Streptomyces Peucetius Doxa: Prediction And Validation Using In Silico And In Vitro Analyses
标题:Understanding Of Real Alternative Redox Partner Of Streptomyces Peucetius Doxa: Prediction And Validation Using In Silico And In Vitro Analyses
摘要:Streptomyces Peucetius Atcc27952 Contains The Cytochrome P450 Monoxygenase Doxa That Is Responsible For The Hydroxylation Of Daunorubicin Into Doxorubicin. Although S. Peucetius Atcc27952 Contains Several Potential Redox Partners,The Most Suitable Endogenous Electron-Transport System Is Still Unclear; Therefore,We Conducted A Study Of Potential Redox Partners Using Accelrys Discovery Studio 3.5. Recombinant Doxa Along With Its Redox Partners From S. Peucetius Fdx1,Fdr2,And Fdx3,And The Putidaredoxin And Putidaredoxin Reductase From Pseudomonas Putida That Are Essential Equivalents Of The Class I Type Of Bacterial Electron-Transport System Were Over-Expressed And Purified. The Successful Development Of An Efficient Redox System Was Achieved By An In Vitro Enzymatic Catalysis Reaction With Doxa. The Optimal Ph For The Activation Of The Heme Was 7.6 And The Optimal Temperature Was 30 Degrees C. Our Findings Suggest A Two-Fold Increase Of Doxa Activity Via The Nadh-> Fdr2-> Fdx1-> Doxa Pathway For The Hydroxylation Of The Daunorubicin,And Indicate That The Usage Of A Native Redox Partner May Increase Daunorubicin-Derived Doxorubicin Production Due To The Inclusion Of Doxa. (C) 2015 Elsevier Inc. All Rights Reserved.
Doi:10.1016/j.Abb.2015.08.019

专利信息

专利号:US-2011245484-A1
优先权日:2010-03-31
标 题 :Stereoselective synthesis of phosphorus containing actives

专利号:WO-2011123668-A2
优先权日:2010-03-31
标 题:Stereoselective synthesis of phosphorus containing actives

专利号:EP-2752422-A1
优先权日:2010-03-31
标 题 :Stereoselective synthesis of phosphorus containing actives

专利号:EP-2752422-B1
优先权日:2010-03-31
标题:Stereoselective synthesis of phosphorus containing actives

专利号:EP-2552931-B1
优先权日:2010-03-31
标题:Stereoselective synthesis of phosphorus containing actives

专利号:US-8859756-B2
优先权日:2010-03-31
标 题 :Stereoselective synthesis of phosphorus containing actives
发明人：ROSS BRUCE S; SOFIA MICHAEL JOSEPH; PAMULAPATI GANAPATI REDDY; RACHAKONDA SUGUNA; ZHANG HAI-REN
权利人:ROSS BRUCE S; SOFIA MICHAEL JOSEPH; PAMULAPATI GANAPATI REDDY; RACHAKONDA SUGUNA; ZHANG HAI-REN; GILEAD PHARMASSET LLC
摘要:Disclosed herein are phosphorus-containing actives, their use as actives for treating diseases, and a stereoselective process for preparing the same. Also disclosed herein are useful synthetic intermediates and processes for preparing the same.