CAS: 2849-93-6; 1H-Benzimidazole-2-Carboxylic Acid

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4856-97-7 3314-30-5 5805-53-8

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CAS号3584-65-4 2-(三氯甲基)-苯并咪唑 | CAS号4856-97-7 2-羟甲基苯并咪唑 | CAS号51-17-2 苯并咪唑 | CAS号95-54-5 邻苯二胺(OPD) | CAS号67162-12-3 2-(α-methylstyr... | CAS号5436-00-0 (9ci)-1H-苯并咪唑-2-羧酸肼 | CAS号74527-53-0 N1-butyl-N2-(2-... | CAS号17293-40-2 ethyl 2-(2-nitr... | CAS号88-74-4 2-硝基苯胺 | CAS号5805-52-7 1H-苯并咪唑-2-甲酰胺 | CAS号51-17-2 苯并咪唑 | CAS号2849-92-5 1-甲基-1H-苯并咪唑-2-羧酸甲酯 | CAS号30183-14-3 1H-Benzimidazol... | CAS号18773-95-0 2-乙酰基苯并咪唑 | CAS号73903-18-1 5-硝基-1H-苯并咪唑-2-羧酸 | CAS号1865-09-4 1H-苯并咪唑-2-羧酸乙酯 | CAS号6965-02-2 (2-苯并咪唑-2-基)-氢苯并咪唑 | CAS号5436-00-0 (9ci)-1H-苯并咪唑-2-羧酸肼

Benzimidazol-2-Carbonsaeureazid 反应生成1H-苯并咪唑-2-甲酸
参考文献:Graubaum,Heinz; Martin,Dieter,Journal Fur Praktische Chemie (Leipzig 1954),1986,Vol. 328,# 4,P. 515-521
标题:Graubaum,Heinz; Martin,Dieter,Journal Fur Praktische Chemie (Leipzig 1954),1986,Vol. 328,# 4,P. 515-521

专利信息

专利号:US-8735586-B2
优先权日:2007-06-26
标 题 :Regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles
发明人：ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARÉ MARC; URMANN MATTHIAS; HALLAND NIS; RKYEK OMAR
权利人:ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARÉ MARC; URMANN MATTHIAS; HALLAND NIS; RKYEK OMAR; SANOFI SA
摘要:The present invention relates to a process for the regioselective synthesis of compounds of the formula I, n nwherein R0; R1; R2; R3; R4; R5; A1; A2; A3; A4, Q and J have the meanings indicated in the claims. The present invention provides a direct copper catalyzed regioselective process to a wide variety of unsymmetrical, multifunctional N-substituted benzimidazoles or azabenzimidazoles of formula I starting from 2-halo-nitroarenes and N-substituted amides.

专利号:US-8188282-B2
优先权日:2006-07-15
标 题:Regioselective palladium catalyzed synthesis of benzimidazoles and azabenzimidazoles
发明人：ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARE MARC; HALLAND NIS; RKYEK OMAR; URMANN MATTHIAS
权利人:ALONSO JORGE; LINDENSCHMIDT ANDREAS; NAZARE MARC; HALLAND NIS; RKYEK OMAR; URMANN MATTHIAS; SANOFI AVENTIS
摘要:The present invention relates to a process for the regioselective synthesis of compounds of the formula I, n nwherein R0; R1; R2; R3; R4; R5; A1; A2; A3; A4, Q and J have the meanings indicated in the claims. The present invention provides a direct palladium catalyzed, regioselective process to a wide variety of unsymmetrical, multifunctional N-substituted benzimidazoles or azabenzimidazoles of formula I starting from 2-halo-nitroarenes and N-substituted amides useful for the production of pharmaceuticals, diagnostic agents, liquid crystals, polymers, herbicides, fungicidals, nematicidals, parasiticides, insecticides, acaricides and arthropodicides.

专利号:US-2023405565-A1
优先权日:2022-06-21
标 题:Catalyst composition for biaryl synthesis by decarboxylative cross-coupling
发明人：LIM CHERN-HOOI; QIAN GANG; ELDER WILLIAM ZACHARY; RILEY PAIGE; KOLVENBACH ROBIN; WALTER PHILIPP; GOCK MICHAEL
权利人:HERAEUS DEUTSCHLAND GMBH & CO KG; NEW IRIDIUM INC
摘要:The present invention relates to a catalyst composition for synthesis of heteroaromatic biaryls by a light-assisted decarboxylative carbon-carbon cross-coupling reaction, wherein the composition comprises(i) a palladium compound which is selected from a palladium salt or a palladium complex or a mixture thereof,(ii) at least one of the following compounds:a compound of Formula (I)a compound of Formula (II)an iridium complex comprising ligands L1, L2 and L3, wherein the ligands L1, L2 and L3 are selected, independently from each other, from a phenylpyridine and a bipyridine.

专利号:US-11673912-B2
优先权日:2018-02-16
标 题 :Continuous, solvent-free and non-enzymatic peptide synthesis by reactive extrusion
发明人：YEBOUE YVES; GALLARD BENJAMIN; LE MOIGNE NICOLAS; LAMATY FRÉDÉRIC; MARTINEZ JEAN; METRO THOMAS-XAVIER
权利人:CENTRE NAT RECH SCIENT; UNIV MONTPELLIER; ENSCM; ECOLE DES MINES DALES; ASSOCIATION POUR LA RECH ET LE DEVELOPPEMENT DES METHODES ET PROCESSUS INDUSTRIELS
摘要:A continuous, solvent-free and non-enzymatic method for synthesizing a compound of formula (I): Ra-POLYPEP-Rc (I) wherein: POLYPEP is a poly-amino acid compound, Ra and Rc are as specified, the method including the steps of: a) feeding an extrusion reactor with (1) a compound of formula (II) Ra-PEPNt-Rg (II) wherein; PEPNt is a mono- or a poly-amino acid compound, Ra and Rg are as specified, and (2) a compound of formula (III) H-PEPCt-Rc (III) wherein: PEPCt is a mono- or a poly-amino acid compound, and Rc is as defined in the absence of any solvent, so that the compound of formula (II) and the compound of formula (III) react together for generating a compound of formula (I), and b) collecting the compound of formula (I) from the extrusion reactor.

专利号:US-2010261909-A1
优先权日:2007-06-26
标题 :Regioselective copper catalyzed synthesis of benzimidazoles and azabenzimidazoles

专利号:US-2023406826-A1
优先权日:2022-06-21
标 题 :Use of a catalyst composition for biaryl synthesis by decarboxylative cross-coupling
发明人：LIM CHERN-HOOI; QIAN GANG; ELDER WILLIAM ZACHARY; RILEY PAIGE; KOLVENBACH ROBIN; WALTER PHILIPP; GOCK MICHAEL
权利人:HERAEUS DEUTSCHLAND GMBH & CO KG; NEW IRIDIUM INC
摘要:The present invention relates to a process for coupling a heterocyclic aromatic ring AR1 and a carbocyclic or heterocyclic aromatic ring AR2 to each other by a light-assisted decarboxylative carbon-carbon cross-coupling reaction, whereinn a reaction medium is provided by mixing a first reactant, a second reactant and a catalyst composition, wherein the catalyst composition comprises (i) a palladium compound which is a palladium salt or a palladium complex or a mixture thereof, and (ii) a polycyclic compound of Formula (I), (II) or (III): nn n n n n n n n n n n n the reaction medium is irradiated by an external light source, thereby coupling the heterocyclic aromatic ring AR1 of the first reactant to the aromatic ring AR2 of the second reactant by a decarboxylative carbon-carbon cross-coupling reaction.