CAS: 345-16-4; 5-Fluoro-2-Hydroxybenzoic Acid

上下游产品

CAS号368422-23-5 5-fluoro-2-(met... | CAS号1998-90-9 3-(2-acetyloxy-... | CAS号347-54-6 5-氟水杨醛 | CAS号2357-33-7 Benzenemethanol... | CAS号89-57-6 5-氨基水杨酸 | CAS号445-93-2 2-ethoxy-5-fluo... | CAS号371-41-5 4-氟苯酚 | CAS号141362-06-3 1-fluoro-4-(met... | CAS号394-04-7 5-氟-2-甲氧基苯甲酸 | CAS号394-32-1 5-氟-2-羟基苯乙酮 | CAS号391-92-4 5-氟-2-羟基苯甲酸甲酯 | CAS号2728-74-7 Benzoyl chlorid... | CAS号67127-05-3 5-Fluoro-2-hydr... | CAS号443-12-9 5-氟-2-羟基苯甲酸乙酯 | CAS号610797-33-6 2-ethenyl-4-flu... | CAS号610797-48-3 5-fluoro-2-prop... | CAS号4068-62-6 3-氟-5-氟水杨酸

5-氨基水杨酸置于氟化氢吡啶,Sodium Nitrite体系中,用90%的收率获得产物5-氟水杨酸
参考文献:氟化氢与碱结合,通过氨基芳烃的脱氨基氟化,轻松制备芳族氟化物
标题:氟化氢与碱结合,通过氨基芳烃的脱氨基氟化,轻松制备芳族氟化物
摘要:通过将氟化氢与碱溶液结合使用,成功地实现了包括杂芳族化合物在内的氨基芳烃的一锅式脱氨氟化,即氨基芳烃的重氮化,然后将相应的重氮离子进行原位氟脱氮,以高产率生产了氟芳烃.已发现重氮化阶段在有效生产氟代芳烃中起着最重要的作用.它受到hf溶液组成的极大影响,并通过在谨慎控制的条件下使用适量的碱(例如吡啶)来增强.光化学方法有效地促进了氟脱重氮化阶段,从而以高收率提供了具有极性取代基(如羟基,硝基等)的氟代芳烃.
DOI:10.1016/0040-4020(95)00867-8

专利信息

专利号:US-10005720-B2
优先权日:2013-04-05
标题:Compounds useful for the treatment of metabolic disorders and synthesis of the same
发明人：SEXTON JONATHAN Z; BRENMAN JAY E; MUSSO DAVID L
权利人:NORTH CAROLINA CENTRAL UNIV; UNIV NORTH CAROLINA CHAPEL HILL
摘要:The present invention provides compounds of Formula (I): wherein variables X, Y, Z and R1 are as described herein. Some of the compounds described herein are glutamate dehydrogenase activators. The invention is also directed to pharmaceutical compositions comprising these compounds, uses of these compounds and compositions in the treatment of metabolic disorders as well as synthesis of the compounds.

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-2018370905-A1
优先权日:2013-04-05
标题:Compounds Useful for the Treatment of Metabolic Disorders and Synthesis of the Same

专利号:WO-2010126607-A2
优先权日:2009-04-30
标 题:Synthesis of tetracyclines and intermediates thereto

专利号:CN-105503601-A
优先权日:2014-09-25
标 题:Method for the synthesis of 3-acetoxy propionaldehyde by hydroformylation of vinyl acetate

专利号:US-9217012-B2
优先权日:2009-04-08
标题 :Inhibitors of protein tyrosine phosphatases
发明人：ZHANG ZHONG-YIN; ZHANG SHENG
权利人:ZHANG ZHONG-YIN; ZHANG SHENG; UNIV INDIANA RES & TECH CORP
摘要:Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC-PTP. Also provided are methods of using the compounds and formulations containing the compounds. Also described is a fluorescence-tagged combinatorial library synthesis and screening method. And methods of using these compounds to effect enzyme activity both in cells and in vitro as well as method of using these compounds to treat diseases in human and animals.