CAS: 39910-98-0; 4'-Morpholinoacetophenone

上下游产品

4-(4-溴苯基)吗啉 4-Bromophenyl-Morpholine 30483-75-1
4-氨基苯乙酮 4-Aminoacetophenone 99-92-3

4-碘代苯乙酮置于potassium Fluoride,对甲苯磺酸一水合物,间氯过氧苯甲酸体系中,用 水,1,2-二氯乙烷,乙腈 作为反应溶剂,化学反应 25.25H,反应生成 4-(4-吗啉基)苯乙酮
参考文献:芳胺的无金属合成:超越亲核芳香取代
标题:芳胺的无金属合成:超越亲核芳香取代
摘要:描述了一种温和且无金属的c-N偶联方法,该方法使用二芳基碘鎓盐亲电试剂和脂肪族仲胺亲核试剂.该反应导致碘鎓部分直接ipso取代,主要使用不对称的芳基(tmp)碘鎓盐.此外,可以容纳目前对经典的无金属方法构成挑战的芳烃取代基和取代形式,并且此处使用的脂环族胺亲核试剂在其他当代的无金属cn偶联反应中是前所未有的.
DOI:10.1002/anie.201610086

专利信息

专利号:US-6413957-B1
优先权日:1998-04-21
标题:Methods of inhibiting cell proliferation using indeno [1,2-c]pyrazol-4-ones
发明人：NUGIEL DAVID A; CARINI DAVID J; DI MEO SUSAN V; YUE EDDY W
权利人:BRISTOL MYERS SUIBB PHARMA COM
摘要:The present invention relates to the synthesis of a new class of indeno[1,2-c]pyrazol-4-ones of formula (I): n that are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cdk1-7 and their regulatory subunits know as cyclins A-G. This invention also provides a novel method of treating cancer or other proliferative diseases by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative diseases by administering a therapeutically effective combination of one of the compounds of the present invention and one or more other known anti-cancer or anti-proliferative agents.

专利号:US-6689882-B2
优先权日:2000-05-18
标 题 :Process for the synthesis of morpholinylbenzenes
发明人：TIAN WEI
权利人:ASTRAZENECA AB
摘要:A new improved process for synthesizing morpholinylbenzenes of the formula I by reacting morpholine of formula II with a substituted benzene of formula III, wherein morpholine is used as a reactant and as the only one solvent.

专利号:US-7250435-B2
优先权日:1999-10-20
标 题:Acylsemicarbazides as cyclin dependent kinase inhibitors useful as anti-cancer and anti-proliferative agents
发明人：NUGIEL DAVID A; CARINI DAVID J; DI MEO SUSAN V; VIDWANS ANUP P; YUE EDDY
权利人:BRISTOL MYERS SQUIBB PHARMA CO
摘要:The present invention relates to the synthesis of a new class of indeno[1,2-c]pyrazol-4-ones of formula (I): n nthat are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cdk1-7 and their regulatory subunits know as cyclins A-G.n n This invention also provides a novel method of treating cancer or other proliferative diseases by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative diseases by administering a therapeutically effective combination of one of the compounds of the present invention and one or more other known anti-cancer or anti-proliferative agents.

专利号:US-2003171581-A1
优先权日:2000-05-18
标题:Process for the synthesis of morpholinylbenzenes

专利号:US-6407103-B2
优先权日:1998-04-21
标 题:Indeno [1,2-c] pyrazol-4-ones and their uses
发明人：NUGIEL DAVID A; CARINI DAVID J; DI MEO SUSAN V; YUE EDDY W
权利人:BRISTOL MYERS SQUIBB PHARMA CO
摘要:The present invention relates to the synthesis of a new class of indeno[1,2-c]pyrazol-4-ones of formula (I):that are potent inhibitors of the class of enzymes known as cyclin dependent kinases, which relate to the catalytic subunits cdk1-9 and their regulatory subunits know as cyclins A-H.This invention also provides a novel method of treating cancer or other proliferative diseases by administering a therapeutically effective amount of one of these compounds or a pharmaceutically acceptable salt form thereof. Alternatively, one can treat cancer or other proliferative diseases by administering a therapeutically effective combination of one of the compounds of the present invention and one or more other known anti-cancer or anti-proliferative agents.

专利号:US-2008045708-A1
优先权日:2000-05-18
标 题 :New Process for the Synthesis of Morpholinylbenzenes