CAS: 614-97-1; 5-Methyl-1H-Benzo[d]Imidazole

相似化合物

582-60-5 6287-83-8 1792-41-2

上下游产品

2-巯基-5-甲基苯并咪唑 5-Methyl-1H-Benzoimidazole-2-Thiol 27231-36-3
(9Ci)-1H-苯并咪唑-5-乙腈 (1(3)H-Benzimidazol-5-yl)-Acetonitrile 110925-52-5
1-(5-Methyl-1H-Benzo[d]Imidazol-2-yl)Ethane-1,2-Diol

2-巯基-5-甲基苯并咪唑置于rose Bengal Sodium Salt,水,氧气,Sodium Chloride体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,化学反应 48.0H,以98%的收率获得产物5-甲基苯并咪唑
参考文献:可见光诱导的亚硫酰基对2-巯基苯并咪唑的好氧氧化脱硫
标题:可见光诱导的亚硫酰基对2-巯基苯并咪唑的好氧氧化脱硫
摘要:发现温和的不含过渡金属的无毒需氧光氧化还原系统可实现2-巯基苯并咪唑的高效脱硫.这种可行的催化系统包括低催化剂含量的rose Bengal作为光敏剂,以及廉价的无毒nacl(催化量)作为添加剂,并与氧气气氛相结合.该方案提供了重要的替代途径,可以以通常的高收率获得各种苯并咪唑和氘代苯并咪唑产品,并且对各种合成和药学上有用的功能具有非常好的耐受性.机理研究表明,单电子转移和能量转移都可能在初始步骤发生,并且亚硫酰基自由基中间体参与了关键的脱硫过程.
DOI:10.1039/d0Gc02269A

专利信息

专利号:WO-2023072966-A1
优先权日:2021-10-26
标题:Imidazolone derivatives as inhibitors of protein kinases in particular dyrk1a, clk1 and/or clk4
发明人：DEAU EMMANUEL; GEORGE PASCAL; MEIJER LAURENT; MIEGE FRÉDÉRIC
权利人:PERHA PHARMACEUTICALS
摘要:The present invention relates to a compound of formula (I) wherein R 1 represents a (C 4 -C 6) alkyl group, a (C 3 -C 8) cycloalkyl group, a bridged (C 6 -C 10 )cycloalkyl group, a fused phenyl group, a substituted phenyl group, a R'-L- group, wherein L is either a single bond or a (C 1 -C 3 )alkanediyl group, and R' represents, a (C 3 -C 8 )heterocycloalkyl group, or a (C 3 -C 8 )heteroaryl group, or a R''-L- group wherein L is a (C 1 -C 3 )alkanediyl group, and R'' is an optionally substituted phenyl group; R 2 is selected from the group consisting of a hydrogen atom and a (C 1 -C 3 )alkyl group; R 5 represents a hydrogen atom, a (C 1 -C 4 )alkyl group or a (C 3 -C 6 )cycloalkyl group or any of its pharmaceutically acceptable salt. The present invention further relates to a composition comprising a compound of formula (I) and a process for manufacturing said compound as well as its synthesis intermediates. It also relates to said compound for use as a medicament, in particular in the treatment and/or prevention of cognitive deficits and neuroinflammation associated with Down syndrome; Alzheimer's disease; dementia; tauopathies; Parkinson's disease; CDKL5 Deficiency Disorder; Phelan-McDermid syndrome; autism; type 1 and type 2 diabetes; abnormal folate and methionine metabolism; osteoarthritis and tendinopathy; Duchenne muscular dystrophy; cancers and leukemias; neuroinflammation, anemia, infections caused by unicellular parasites, viral infections and for regulating body temperature.

专利号:US-6140505-A
优先权日:1995-03-10
标 题:Synthesis of benzo fused heterocyclic sulfonyl chlorides

专利号:US-8088884-B2
优先权日:2007-09-27
标 题 :Multi-armed forms of activated polyoxazoline and methods of synthesis thereof
发明人：HARRIS J MILTON; BENTLEY MICHAEL DAVID; YOON KUNSANG; FANG ZHIHAO
权利人:HARRIS J MILTON; BENTLEY MICHAEL DAVID; YOON KUNSANG; FANG ZHIHAO; SERINA THERAPEUTICS INC
摘要:The present disclosure provides novel POZ-2 derivatives, methods for synthesizing POZ-2 derivatives and intermediates useful in such methods. In one embodiment, the POZ-2 derivative comprises two linear POZ chains of the present disclosure linked directly or indirectly to a branching moiety that contains a functional group for linking the POZ-2 derivative to the target molecule. Target molecule-POZ-2 conjugates are also described. In certain embodiment, the POZ-2 derivatives have low polydispersity values and a decreased amount of impurities produced by unwanted side reactions, such as, but not limited to, chain transfer.

专利号:US-11518933-B2
优先权日:2016-05-25
标题:Precursor based method of synthesis and fabrication of hybrid lighting phosphors with high quantum efficiency, and significantly enhanced thermal and photostability
发明人：LI JING; FANG YANG; LIU WEI
权利人:UNIV RUTGERS
摘要:Highly thermal and photo-stable inorganic-organic hybrid phosphor compounds, in which a copper (I) halide module is coordinated with a multi-dentate organic ligand. Also disclosed are semiconductor and light emitting devices comprising these materials, including light emitting diodes, and methods of preparing these materials and devices.

专利号:EP-1600451-A2
优先权日:1999-11-12
标题 :Synthesis of 2'-deoxy-l-nucleosides

专利号:EP-1600452-A2
优先权日:1999-11-12
标题 :Synthesis of 2'-deoxy-L-nucleosides