CAS: 63069-48-7; 4-Chloro-2-Iodoaniline

上下游产品

4-chloro-aniline N-(4-chloro-2-iodophenyl)-2,2,2-trifluoroacetamide N-(4-chloro-2-iodophenyl)acetamide acetophenone 2,5-dichloroiodobenzene 4-chloro-2,6-diiodoaniline N-(4-chloro-2-iodophenyl)acetamide 4-chloro-2-iodothiophenol

对氯苯胺置于碳酸氢钠,碘体系中,用 水 作为反应溶剂,化学反应 12.5H,反应生成 2-碘-4-氯苯胺
参考文献:Pd/c-Mediated Synthesis Of Indoles In Water
标题:Pd/c-Mediated Synthesis Of Indoles In Water
摘要:我们描述了在水中通过偶联-环化策略使用pd/c-Cu介导方法合成2,5-二取代吲哚的效用.进一步应用这种方法论已经在通过7步过程制备目标吲哚衍生物中得到展示,其中关键步骤是pd/c介导的偶联反应.
DOI:10.3762/bjoc.5.46

专利信息

专利号:US-11427530-B2
优先权日:2018-02-09
标 题 :Synthesis of 4-chlorokynurenines and intermediates
发明人：LEVIN DANIEL; LEEMING PETER; EISENREICH EMERICH; LIU XUEJUN KARL
权利人:VISTAGEN THERAPEUTICS INC
摘要:The invention relates to an overall enantio-specific synthesis of 4-chlorokynurenine compounds, in particular L-4-chlorokynurenine, with improved yields. Large-scale syntheses are disclosed. The invention also relates to novel intermediates in the synthesis of L-4-chlorokynurenine.

专利号:US-7582771-B2
优先权日:2003-09-03
标题:Process for the synthesis of cPLA2 inhibitors
发明人：DEHNHARDT CHRISTOPH M; MEGATI SREENIVASULU; MICHALAK RONALD S; RAVEENDRANATH PANOLIL; REN JIANXIN; WU CHARLES C; WU YANGZHONG
权利人:WYETH CORP
摘要:A process for making the compound of formula (I) n nwherein Ac represents acetate; X represents O or CH 2 ; Y represents C 1 -C 6 alkyl; and Z is selected from the group consisting of H, halogen, CN, CHO, CF 3 , OCF 3 , OH, C 1 -C 6 alkyl, C 1 -C 6 alkoxy, C 1 -C 6 thioalkyl, NH 2 , N(C 1 -C 6 alkyl) 2 , NH(C 1 -C 6 alkyl), NC(O)—(C 1 C 6 alkyl), and NO 2 . In his process, a compound of formula (II)n n nis reacted with hydrazine to form a primary alkylamine, and then the primary alkylamine is reacted with acetic anhydride, to produce the compound of formula (I).

专利号:WO-2025045973-A1
优先权日:2023-08-31
标题 :Synthesis of lanifibranor intermediate
发明人：BOUBIA BENAÃ?SSA; GONZALEZ JÉRÔME; BELL FRÉDÉRIC
权利人:INVENTIVA
摘要:The present disclosure is directed to a process for preparing a compound of formula (I), which comprises a palladium-free coupling reaction between N-(4-chloro-2-iodo-phenyl)-1,3-benzothiazole-6-sulfonamide and methyl 5-hexynoate in the presence of a copper catalyst.

专利号:US-7342119-B2
优先权日:2003-09-30
标题 :Process for the synthesis of a CPLA2 inhibitor
发明人：DEHNHARDT CHRISTOPH M; MEGATI SREENIVASULU; MICHALAK RONALD S; RAVEENDRANATH PANOLIL
权利人:WYETH CORP
摘要:A process for making a substituted indole compound, including the steps of: reacting the compounds n nin a non-protic polar solvent in the presence of a catalyst to form the intermediate compoundn n nwherein Ph and X are as defined herein; and then,n nheating this intermediate compound in the solvent in the presence of the catalyst to form the substituted indole compoundn n nThe invention also includes compounds formed by this process.

专利号:US-2005049296-A1
优先权日:2003-09-03
标 题 :Process for the synthesis of cPLA2 inhibitors

专利号:EP-3749638-A1
优先权日:2018-02-09
标 题 :Synthesis of 4-chlorokynurenines and intermediates