CAS: 69249-22-5; 3-Amino-6-Bromo-1,2,4-Triazine

上下游产品

CAS号1120-99-6 3-氨基-1,2,4-三嗪 | CAS号18915-36-1 1,2,4-Triazin-3...

1,2,4-三嗪-3-胺置于溴体系中,用 甲醇,水 作为反应溶剂,化学反应生成 6-溴-1,2,4-噻嗪-3-胺
参考文献:Reactions Of 3-Amino-1,2,4-Triazine With Coupling Reagents And Electrophiles
标题:Reactions Of 3-Amino-1,2,4-Triazine With Coupling Reagents And Electrophiles
摘要:摘要 在钯催化剂存在下,3-氨基-1,2,4-三嗪与硼酸等偶联试剂和末端炔烃发生反应,获得了一种新杂环系统的类似物.还进行了其他反应,如三嗪第 5 位的胺化反应,然后与苯基异氰酸酯和苯甲酰氯发生亲电反应,反应生成新的单酰基和苯甲酰基化合物.
DOI:10.1515/hc-2022-0149

专利信息

专利号:US-2010004245-A1
优先权日:2006-10-20
标 题:Azacycloalkane derivatives as inhibitors of stearoyl-coenzyme a delta-9 desaturase
发明人：OBALLA RENATA M; DESCHENES DENIS; GAGNON MARC; LEBLANC YVES; POWELL DAVID; RAMTOHUL YEEMAN K
权利人:MERCK FROSST CANADA LTD
摘要:Azacycloalkane derivatives of structural formula (I) are selective inhibitors of stearoyl-coenzyme A delta-9 desaturase (SCD1) relative to other known stearoyl-coenzyme A desaturases. The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease, such as atherosclerosis; obesity; diabetes; neurological disease; metabolic syndrome; insulin resistance; and liver steatosis.