CAS: 98-16-8; 3-Aminobenzotrifluoride

上下游产品

3-trifluoromethylnitrobenzene 2-[3-(trifluoromethyl)phenyl]-1H-isoindole-1,3(2H)-dione 1-chloro-2-(trifluoromethyl)benzene diisobutylamine N,N-bis(2-hydroxyethyl)-3-trifluoromethylaniline 3-oxo-N-[3-(trifluoromethyl)phenyl]butanamide 3-(3-trifluoromethyl-phenylazo)-pyridine-2,6-diamine (3-diethylamino-propyl)-[3-(3-trifluoromethyl-anilino)-propyl]-sulfide

3-(三氟甲基)苯硼酸置于n-溴代丁二酰亚胺(Nbs),氰胺,[双(三氟乙酰氧基)碘]苯体系中,用 乙腈 作为反应溶剂,化学反应 1.0H,以71%的收率获得产物间氨基三氟甲苯
参考文献:氰基/芳基氰酰胺基自由基作为氨基物种的硼酸金属和无碱化学选择性伯胺化反应:密度泛函理论的合成和机理研究
标题:氰基/芳基氰酰胺基自由基作为氨基物种的硼酸金属和无碱化学选择性伯胺化反应:密度泛函理论的合成和机理研究
摘要:在环境温度下,由[双(三氟乙酰氧基)碘]苯(pifa)和n-溴代琥珀酰亚胺介导了从相应的硼酸高效,无金属,无金属,化学选择性地合成芳基,杂芳基和烷基伯胺的过程.(nbs)使用氰基酰胺基/芳基氰基酰胺基作为胺化物质.最初以其相应的三氟乙酸铵盐形式获得伯胺化合物,其在用naoh水溶液处理后提供游离胺.最后,伯胺通过硅胶柱色谱分离,使用己烷-Etoac溶剂系统作为洗脱剂.反应足够快,可以在1小时内完成.结合实验观察的量子化学计算验证了ipso 取代的硼酸的氨基化涉及氰基ami基/芳基氰基ami基的形成,随后其腈-N中心与硼酸的硼原子的区域专一性相互作用,导致化学选择性的伯胺化.
DOI:10.1021/acs.Joc.6B00671

专利信息

专利号:US-5811586-A
优先权日:1996-05-29
标 题 :Process for manufacturing 1-(3-trifluoromethyl)-phenyl-propan-2-one intermediate in the synthesis of the fenfluramine
发明人：CANNATA VINCENZO; GALBIATI BARBARA; SPREAFICO ANGELO
权利人:ALFA CHEM ITAL
摘要:A process for manufacturing 1-(3-trifluoromethyl)phenyl-propan-2-one intermediate in the synthesis of the anorexic drug fenfluramine consists of reacting the diazonium salt of 3-trifluoromethylaniline with isopropenyl acetate in a polar solvent in the presence of a catalytic amount of a cuprous salt and, optionally, of a base and purifying the crude product through the bisulfite complex or distillation under vacuum.

专利号:US-4264775-A
优先权日:1976-10-27
标 题:Synthesis of β-aminostyrenes
发明人：WHITE WILLIAM A
权利人:LILLY CO ELI
摘要:A simple process for the preparation of beta -aminostyrenes proceeds from anilines by successively diazotizing, reacting with a vinyl ester, and reacting with a secondary amine without purification of the intermediate products. The compounds are reactive enamines useful in organic synthesis.

专利号:US-4822903-A
优先权日:1981-05-15
标题:Fluorinated silica catalyst and preparation of aromatic/aliphatic nitriles in the presence thereof
发明人：JACQUES ROLAND; REPPELIN MICHEL; SEIGNEURIN LAURENT
权利人:RHONE POULENC SPEC CHIM
摘要:An improved fluorinated siliceous catalyst, well adapted for the catalytic synthesis of aromatic/aliphatic nitriles from their corresponding formamides, formanilides or amides, is comprised of a plurality of silica particulates, the specific surface of which ranging from about 200 to about 300 m 2 /g, having a total pore volume ranging from about 1 to about 1.5 cm 3 /g, with an average pore diameter ranging from about 100 to about 200 â„«, having an exchange pH of less than about 3, and with the fluorine content thereof bonded to the silica, expressed in F 31 , ranging from about 0.05 to about 2% by weight based upon the silica, and the sodium content thereof, expressed as Na 2 O, being less than about 1% by weight, also based upon the silica.

专利号:US-4255581-A
优先权日:1979-08-13
标题 :Process for the preparation of alkyl and aryl esters of 3'-substituted and 2', 3'-disubstituted 2-anilino-3-pyridinecarboxylic acids
发明人：LOS MARIO A
权利人:LAB BAGO S A
摘要:In this disclosure, the synthesis of alkyl and aryl esters of substituted 2-anilino-3-pyridinecarboxylic acids is described. This preparation is performed reacting a previously obtained alkyl or aryl ester of 2-chloro-3-pyridinecarboxylic acid, with 3,2 or 3-substituted aniline.

专利号:US-4897484-A
优先权日:1986-12-19
标题 :Process for the preparation of substituted pyridines
发明人：WEIS CLAUS D; SUTTER PETER
权利人:CIBA GEIGY CORP
摘要:A process is described for the preparation of compounds of the formula (1) in which R and X are as defined in claim 1. The compounds of the formula (1) are valuable intermediates in the synthesis of triarylmethane dyes and triarylmethanelactones.

专利号:WO-2024028893-A1
优先权日:2022-08-01
标 题:Substituted benzimidazoles for treating viral diseases
发明人：CHAUDHARI VINOD DINKAR; THAKUR KRISHAN GOPAL; RINGE RAJESH PRAKASH; SINGH DESHKANWAR; KAUR SIMRAN; CHAWLA RAVNEET SINGH; JOSHI AKSHAY
权利人:COUNCIL OF SCIENT AND INDUSTRIAL RESEARCH AN INDIAN REGISTERED BODY INCORPORATED UNDER THE REGN OF S
摘要:The invention relates to benzimidazole compounds, pharmaceutically acceptable salts thereof and its pharmaceutical compositions for reducing/treating viral infections. The present invention also relates to synthesis of such benzimidazole compounds. The present invention further relates to compositions which comprise such benzimidazole compounds or a pharmaceutically acceptable salt thereof, and a pharmaceutically acceptable carrier, optionally in combination. The compounds of the invention are useful in reducing/treating viral infections particularly coronavirus infections caused by SARS-CoV, MERS-CoV and SARS-CoV-2.