CAS: 1022-79-3; 4-Amino-5-Bromo-1-((2R,4S,5R)-4-Hydroxy-5-(Hydroxymethyl)Tetrahydrofuran-2-yl)Pyrimidin-2(1H)-One

上下游产品

2'-Deoxycytidine 2'-deoxycytidine monohydr°Chloride 5-bromo-2'-deoxy-5'-O-p-toluenesulfonylcytidine 2'-Deoxycytidine 4-N-benzoyl-5-bromodeoxycytidine 4-N-benzoyl-5-bromo-5'-O-(4,4'-dimethoxytrityl)-deoxycytidine 3'-(2-cyanoethyl N,N-diisopropylphosphoramidite)

2'-脱氧胞苷盐酸盐置于溴体系中,用 水 用作溶剂,化学反应生成5-溴-2'-脱氧胞苷
参考文献:Synthesis And Binding Property Of An Oligonucleotide Containing Tetrafluorophenoxazine
标题:Synthesis And Binding Property Of An Oligonucleotide Containing Tetrafluorophenoxazine
摘要:A Tricyclic Pyrimidine Nucleoside Analog,Termed Tetrafluorophenoxazine,Has Been Synthesized And Incorporated Into An Oligonucleotide. Tm Analyses Demonstrate That This Analog Is Capable Of Enhanced Recognition Of Both A Complementary Adenine And Guanine Within A Dna Helix. (C) 1998 Elsevier Science Ltd. All Rights Reserved.
Doi:10.1016/s0040-4039(98)01932-7

专利信息

专利号:EP-1383732-B1
优先权日:2001-05-04
标题:Labelling reagents, method for synthesis of said reagents and methods for detecting biological molecules
发明人：BOURGET CECILE; LHOMME JEAN; LAAYOUN ALI; KOTERA MITSUHARU; TREVISIOL EMMANUELLE; MENOU LIONEL; BERNAL MENDEZ ELOY
权利人:BIO MERIEUX; UNIV GRENOBLE 1; CENTRE NAT RECH SCIENT
摘要:The invention concerns a temperature-stable labelling reagent of formula (I), wherein: R<1> represents H or an alkyl, aryl or substituted aryl group; R<2> represents a detectable marker or at least two detectable markers linked together by at least a multimeric structure; L is a linking arm comprising a linear catemer concatenation of at least two covalent bonds; and n is an integer equal to 0 or 1; R<3> and R<4> represent, independently of each other: H, NO2, Cl, Br, F, I, R<2>-(L)n-Y-X-, OR, SR, NR2, R, NHCOR, CONHR, COOR with R = alkyl or aryl, A is a linking arm comprising at least a double bond enabling the conjugation of the diazo function with the aromatic cycle; and u is a whole number between 0 and 2, preferably between 0 and 1; and -Y-X- represents -CONH-, -NHCO-, -CH2O-, -CH2S-. The invention also concerns a method for the synthesis of said markers and uses for labelling biological molecules, in particular nucleic acids, with a labelling reagent bearing the diazomethyl function. The invention is particularly applicable in the field of diagnosis.

专利号:US-9605261-B2
优先权日:2008-09-06
标 题:RNA synthesis—phosphoramidites for synthetic RNA in the reverse direction, and application in convenient introduction of ligands, chromophores and modifications of synthetic RNA at the 3′-end
发明人：SRIVASTAVA SURESH C; PANDEY DIVYA; BAJPAI SATYA P; SRIVASTAVA NAVEEN P
权利人:CHEMGENES CORP
摘要:The present invention relates to novel phosphoramidites, A-n-bz, C-n-bz, C-n-ac, G-n-ac and U are produced with an HPLC purity of greater than 98% and 31 P NMR purity greater than 99%. A novel process of reverse 5′→3′ directed synthesis of RNA oligomers has been developed and disclosed. Using that method demonstrated high quality RNA synthesis with coupling efficiency approaching 99%.

专利号:US-8324149-B2
优先权日:2008-11-18
标 题:Encapsidation of heterologous entities into virus-like particles
发明人：BUNDY BRADLEY C; SWARTZ JAMES R; CHAN WEI
权利人:BUNDY BRADLEY C; SWARTZ JAMES R; CHAN WEI; UNIV LELAND STANFORD JUNIOR
摘要:Methods are provided for the utilization of bacterial cell-free extracts in the synthesis of high yields of virus like particles with encapsidated cargo.

专利号:US-2003224420-A1
优先权日:2002-04-05
标题 :Method for isolating and measuring proliferation of long-term label retaining cells and stem cells
发明人：HELLERSTEIN MARC K; KIM SYLVIA JEEWON
摘要:This invention relates to a method for separating long-term label retaining cells or stem cells. In particular, this invention relates to a method for separating long-term label retaining cells and/or stem cells from tissues or individuals and for measuring proliferation rates of long-term label retaining cells and stem cells, as well as determining clonal expansion (proliferative history) of cell lineages from the tissues of the individual. The cells may be double-labeled with a cell-lineage marking label and isotopically labeled DNA synthesis precursor prior to physical separation.

专利号:US-10167523-B2
优先权日:2015-05-05
标题 :Gene impacting biomass formation and recalcitrance and methods of use
发明人：TUSKAN GERALD A; KALLURI UDAYA C
权利人:UT BATTELLE LLC
摘要:The invention provides plants having improved biomass properties of increased biomass quantity and density, increased cellulose content and deceased lignin content and improved sugar release efficiency, methods of generating (genetically modifying) and/or selecting (natural variant collections) plants with such preferred attributes of cellulose, lignin and sugar release, and uses of such plants. The inventors have determined that the expression of the gene, Potri.001G375700 (belonging to IQD signaling protein family containing a canonical calmodulin-binding domain) and/or activity of Potri.001G375700, modulates cellulose, lignin synthesis, sugar release and growth in plants.

专利号:US-9803240-B2
优先权日:2008-04-01
标题 :Stabilized nucleic acid dark quencher-fluorophore probes
发明人：COOK RONALD M; LYTTLE MATT
权利人:BIOSEARCH TECH INC
摘要:The present invention provides a new class of solids supports for synthesis of modified oligomers of nucleic acids, and nucleic acid probes that have a format expediently synthesized on the new supports. Exemplary solid supports include at least one quencher bound through a linker to the solid support. Various exemplary embodiments include a moiety that stabilizes a duplex, triplex or higher order aggregation (e.g., hybridization) of nucleic acids of which the oligomer of the invention is a component. Other components of the solid support include moieties that stabilize aggregations of nucleic acids, e.g., intercalators, minor groove binding moieties, bases modified with a stabilizing moiety (e.g., alkynyl moieties, and fluoroalkyl moieties), and conformational stabilizing moieties, such as those described in commonly owned U.S. Patent Application Publication No. 2007/0059752.