CAS: 1195-66-0; 2-Methoxy-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane

相似化合物

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CAS号629-05-0 1-辛炔 | CAS号76-09-5 频哪醇 | CAS号121-43-7 硼酸三甲酯 | CAS号67-56-1 甲醇 | CAS号51608-60-7 N-亚苄基-4-甲基苯磺酰胺 | CAS号73183-34-3 双戊酰二硼 | CAS号732301-91-6 cis-Me(allyl)CC... | CAS号1050423-91-0 2-(2-氟-4-碘苯基)-4... | CAS号408492-28-4 3-碘苯硼酸频哪酯 | CAS号936728-22-2 3-氟-5-(4,4,5,5-... | CAS号937591-48-5 4-methoxy-2-(4,... | CAS号150-76-5 4-甲氧基苯酚(MEHQ) | CAS号365564-11-0 N-TIPS-吡咯-3-硼酸频哪醇酯 | CAS号857934-82-8 2-(2-碘苯基)-4,4,5... | CAS号877399-74-1 4-[4-(4,4,5,5-四... | CAS号287944-10-9 2-(1-环戊基)-4,4,5... | CAS号73852-88-7 4-碘苯硼酸频呢醇酯

Methyl (2E)-2-[(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)Methyl]-But-2-Enoate置于苯甲醛体系中,用 二氯甲烷 用作溶剂,化学反应生成2-甲氧基-4,4,5,5-四甲基-1,3,2-二氧硼戊环
参考文献:新型异构纯四取代烯丙基硼酸酯:α-外亚甲基γ-内酯作为具有立体四元碳中心的类醛醇加合物的立体控制合成
标题:新型异构纯四取代烯丙基硼酸酯:α-外亚甲基γ-内酯作为具有立体四元碳中心的类醛醇加合物的立体控制合成
摘要:尽管它们固有的异构化倾向和低反应性,1-烷氧基羰基乙烯基铜 (I) 中间体在 Hmpa 存在下与碘甲基硼酸酯以非常高的顺式加成选择性捕获了有机铜酸盐与炔酸酯的共轭加成.所得的异构纯 3,3-二取代烯丙基硼酸酯以高度非对映选择性和对映选择性方式与醛反应,提供具有立体异构四元 β-碳中心的 α-外亚甲基 γ-内酯.
Doi:10.1021/ja016391E

专利信息

专利号:US-2011130591-A1
优先权日:2009-06-03
标 题:Steroselective synthesis of certain trifluoromethyl-substituted alcohols
发明人：FANDRICK DANIEL R; REEVES JONATHAN T; SONG JINHUA J
权利人:BOEHRINGER INGELHEIM INT
摘要:A process for synthesis of a compound of Formula (X) n n n n n n n n n n wherein:n R 1 is an aryl group substituted with one to three substituent groups,n wherein each substituent group of R 1 is independently C 1 -C 5 alkyl, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, halogen, carboxy, cyano, or trifluoromethyl,n wherein each substituent group of R 1 is optionally independently substituted with one to three substituents selected from C 1 -C 3 alkyl, C 1 -C 3 alkoxy, phenyl, and alkoxyphenyl; and n n R 2 and R 3 are each independently C 1 -C 5 alkyl.

专利号:US-2025101006-A1
优先权日:2022-01-31
标题:Process for the synthesis of pyrazolyl derivatives useful as anti-cancer agents
发明人：BAENZIGER MARKUS; GALLOU FABRICE; GUO FENGFENG; HÄNGGI RUDOLF; HAN ENJIAN; JORDINE GUIDO; LI JIALIANG; LIU WEIPENG; MIAO BUKEYAN; RONG SHAOFENG; SANTANDREA ERNESTO; SCHIRNER PAUL BERND; SHEN XIAODONG; WANG CAN; ZHANG HAO
权利人:NOVARTIS AG
摘要:The invention provides a novel process, novel process steps and novel intermediates useful in the synthesis of pharmaceutically active compounds, especially KRAS G12C inhibitors. The present invention provides a direct enantioselective chemical manufacturing method of making Compound A, or a pharmaceutically acceptable hydrate or solvent thereof: (I). The invention provides a process for preparing Intermediate B6* comprising reacting Intermediate B4* with Intermediate B5* in an atroposelective coupling reaction, using a chiral catalyst.

专利号:US-2024010638-A1
优先权日:2020-11-13
标题:Improved synthesis of crac channel inhibitors
发明人：STAUDERMAN KENNETH; DUNN MICHAEL; OLMSTEAD KAY
权利人:CALCIMEDICA INC
摘要:Provided herein is an improved synthetic method for the production of CRAC channel inhibitors. The synthetic method provides a method for producing highly pure CRAC channel inhibitors for clinical testing.

专利号:US-9328061-B2
优先权日:2012-03-01
标题:Simple organic molecules as catalysts for practical and efficient enantioselective synthesis of amines and alcohols
发明人：HOVEYDA AMIR H; SILVERIO DANIEL L; PILYUGINA TATIANA; TORKER SEBASTIAN; ROBBINS DANIEL
权利人:TRUSTEES BOSTON COLLEGE
摘要:The present invention provides organic molecules and methods thereof for reactions between organoboron reagents and double bonds, such as imines or carbonyls, to stereoselectively provide chiral products including amines and alcohols, entities useful for the preparation of biologically active molecules.

专利号:US-2012289733-A1
优先权日:2011-05-11
标 题 :Novel borate derivatives and their applications
发明人：HEISE GLENN L; MYSLINSKA MALGORZATA
权利人:HEISE GLENN L; MYSLINSKA MALGORZATA; ANDERSON DEV CO
摘要:Borates, compositions comprising chiral (cyclic and acyclic) and achiral (cyclic and acyclic) borates; chiral (cyclic and acyclic) and achiral (cyclic and acyclic) biborates; and methods for their synthesis. Additionally, a significantly improved synthetic protocol for the synthesis of wide range of boronates starting from borates or biborates and Grignard or organolithium reagents that can be used for kilo lab and commercial scale production.

专利号:WO-2023143605-A1
优先权日:2022-01-31
标 题:Process for the synthesis of pyrazolyl derivatives useful as anti-cancer agents