专利号:US-6841559-B1 优先权日:1999-11-19 标 题:Pyridinones to treat and prevent bacterial infections 发明人:ALMQVIST FREDERIC; EMTENAS HANS; HULTGREN SCOTT J; PINKNER JEROME S 权利人:WASHINGTON UNIVERSITY OF ST LO 摘要:Novel pyridinones and their derivatives which are effective in treating or preventing Gram-negative bacterial infections are provided. The pyridinones are stable and easily derivatized; the methods by which these derivatizations occur is described. Two regioselective and functional group tolerant methods for the synthesis of the novel pyridinones are also provided. One such synthetic method involves reacting an imine and a Meldrum's acid derivative in solution. The other synthetic method is a solid phase synthesis of the pyridinones in which an imine is prepared bound to a solid support and a Meldrum's acid derivative is reacted with the imine. Novel imine intermediates useful in the solid phase and solution methods of synthesizing the pyridionones are also described.
专利号:CN-1233644-C 优先权日:2003-03-03 标 题 :Synthesis method of 4-[[3-(1,6-dihydro-6-oxo-9H-purin-9-yl)-1-oxopropyl]amino]benzoic acid and its salt or ester
专利号:CN-1125020-C 优先权日:1999-10-21 标题:A kind of catalytic synthesis method of methylbenzaldehyde
专利号:CN-1257060-A 优先权日:1999-10-21 标题 :A kind of catalytic synthesis method of methylbenzaldehyde