CAS: 132201-32-2; (2R,3S)-3-Phenylisoserine Hydrochloride

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Methyl Cinnamate置于palladium On Activated Charcoal 盐酸,Sodium Azide,N-甲基吲哚酮,Hydroquinone 1,4-Phthalazinediyl Diether,Potassium Dioxotetrahydroxoosmate(Vi),乙酰溴,氢气,对甲苯磺酸体系中,用 甲醇,二氯甲烷,水,N,N-二甲基甲酰胺,叔丁醇 用作溶剂,-15.0~50.0 °C,101.33 Kpa 条件下,反应 80.0H,反应生成(2R,3S)-3-苯基异丝氨酸盐酸盐
参考文献:Large-Scale And Highly Enantioselective Synthesis Of The Taxol C-13 Side Chain Through Asymmetric Dihydroxylation
标题:Large-Scale And Highly Enantioselective Synthesis Of The Taxol C-13 Side Chain Through Asymmetric Dihydroxylation
摘要:
Doi:10.1021/jo00096A072

专利信息

专利号:US-5932758-A
优先权日:1995-07-04
标 题 :Process for the production β-amino-α-hydroxycarboxylic acids and derivatives thereof
发明人：STINGL KLAUS; KOTTENHAHN MATTHIAS; DRAUZ KARLHEINZ
权利人:DEGUSSA
摘要:Disclosed is a process for producing β-amino-α-hydroxycarboxylic acid derivatives of general formula (2R,3S)- or (2S,3E)-N-(X,Y)-3-amino-2-hydroxy-3-phenyl propionic acid-Z of Formula I, ##STR1## e.g. of (2E,3S)-3-amino-2-hydroxy-3-phenyl propionic acid or (2R,3S)-N-benzoyl-3-amino-2-hydroxy-3-phenyl propionic acid methylester. Compounds of type I are valuable intermediates in the total synthesis of Taxols which can be used in the treatment of various forms of cancer.