3-氯-6-甲基哒嗪置于硝酸体系中,化学反应生成6-甲基-3(2H)-哒嗪酮 参考文献:Homer Et Al.,Journal Of The Chemical Society,1948,P. 2191,2194 标题:Homer Et Al.,Journal Of The Chemical Society,1948,P. 2191,2194
专利信息
专利号:US-2008269233-A1 优先权日:2005-08-04 标 题:Piperidinoyl-Pyrrolidine and Piperidinoyl-Piperidine Compounds 发明人:ANDREWS MARK DAVID; BROWN ALAN DANIEL; SEBASTIEN DAVID; LANSDELL MARK IAN 权利人:ANDREWS MARK DAVID; BROWN ALAN DANIEL; SEBASTIEN DAVID; LANSDELL MARK IAN 摘要:The present invention relates to a class of compounds of general formula (I) n n n n n n n n n n and the salts, hydrates, solvates, polymorphs and prodrugs wherein n, R 6 , R 7 and R 10 are as defined herein and especially to MCR4 agonist compounds of formula (I), to their use in medicine, particularly in the treatment of sexual dysfunction and obesity, to intermediates useful in their synthesis and to compositions containing them.
专利号:US-8138188-B2 优先权日:2006-02-23 标题 :Melanocortin type 4 receptor agonist piperidinoylpyrrolidines 发明人:ANDREWS MARK DAVID; BROWN ALAN DANIEL; LANSDELL MARK IAN; SUMMERHILL NICHOLAS WILLIAM 权利人:ANDREWS MARK DAVID; BROWN ALAN DANIEL; LANSDELL MARK IAN; SUMMERHILL NICHOLAS WILLIAM; PFIZER 摘要:The present invention relates to a class of melanocortin MCR4 agonists of general formula (I) n nwherein the variables and substituents are as defined herein and especially to selective MCR4 agonist compounds, to their use in medicine, particularly in the treatment of sexual dysfunction and obesity, to intermediates useful in their synthesis and to compositions containing them.
专利号:US-9533996-B2 优先权日:2012-06-18 标 题 :Therapeutic thiophene-, furan-, and pyridine-fused azolopyrimidin-5-(6h)-ones 发明人:BRANSTETTER BRYAN; BREITENBUCHER JAMES; DYCK BRIAN; GOMEZ LAURENT; HUDSON ANDREW RICHARD; MARRONE TAMI JO; PETERS MARCO; VICKERS TROY; WEINHOUSE MICHAEL 权利人:DART NEUROSCIENCE (CAYMAN) LTD 摘要:Described herein are compounds of Formula I and Formula II, methods of their synthesis, compositions comprising the compounds, and use of the compounds and compositions in treating numerous diseases and disorders, including cognitive deficits associated with CNS diseases and disorders.
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