CAS: 144230-50-2; 4-Methylenepiperidine Hydrochloride

相似化合物

3522-98-3 159635-49-1 138163-12-9

Ethyl 4-Methylenepiperidine-1-Carboxylate置于盐酸,Sodium Hydroxide体系中,用 乙醇,乙二醇 用作溶剂,化学反应生成4-亚甲基哌啶盐酸盐
参考文献:鲁棒性制备高质量4-亚甲基哌啶盐酸盐的方法的开发
标题:鲁棒性制备高质量4-亚甲基哌啶盐酸盐的方法的开发
摘要:设计了制备4-亚甲基哌啶盐酸盐1的有效途径,然后开发了可大规模生产的可行方法,总产率为83.5%,纯度为99.9%.
Doi:10.1021/acs.Oprd.7B00350

专利信息

专利号:US-10626102-B2
优先权日:2015-12-30
标题 :Process for the synthesis of efinaconazol
发明人：VERONESE MARTINO; BETTONI PIERGIORGIO; ROLETTO JACOPO; PAISSONI PAOLO
权利人:PROCOS SPA
摘要:Disclosed is a process for the synthesis of efinaconazole (I), starting from 1-[[(2R,3S)-2-(2,4-difluorophenyl)-3-methyloxiranyl]methyl]-1H-1,2,4-triazole and 4-methylenepiperidine, as free base or hydrochloride, in an organic solvent, under anhydrous conditions and in the presence of neutralising agents and reaction-promoting metal species. (1) The process is particularly advantageous because it gives rise to efinaconazole in high yields and purity, and uses little more than the stoichiometric amount of 4-methylenepiperidine, a rather expensive commercially available reagent.

专利号:EP-3091007-A1
优先权日:2015-05-08
标 题 :Process for the preparation of piperidine compounds
发明人：ATTOLINO EMANUELE; RIZZO ELISABETH; ROSSI DAVIDE
权利人:DIPHARMA FRANCIS SRL
摘要:The present invention relates to a process for the preparation of intermediates useful in the synthesis of efinaconazole and their use in the synthesis of efinaconazole.

专利号:CN-116589447-A
优先权日:2023-04-28
标 题 :A chemical-enzyme process synthesis method of efluconazole