CAS: 23357-46-2; (R)-1,2,3,4-Tetrahydronaphthalen-1-Amine

上下游产品

CAS号2217-40-5 1,2,3,4-四氢-1-萘胺 | CAS号298-12-4 乙醛酸 | CAS号1055321-32-8 (R)-(+)-1-azido... | CAS号529-34-0 1-四氢萘酮 | CAS号68253-36-1 1-tetralone oxime | CAS号119-64-2 1,2,3,4-四氢萘(THN) | CAS号53732-47-1 (S)-(+)-1,2,3,4... | CAS号6094-36-6 N-苯甲酰-L-谷氨酸 | CAS号960128-64-7 (R)-8-(二苯基膦)-1,... | CAS号114419-88-4 (R)-n-甲基-1,2,3,...

1,2,3,4-四氢-1-萘酚置于(R)-Amine Trans-Aminase,Sodium Anthraquinone-2-Sulfonate,氧气体系中,用 水,乙腈 用作溶剂,化学反应 22.5H,反应生成(R)-(-)-1,2,3,4-四氢-1-萘胺
参考文献:结合光有机氧化还原和酶催化促进不对称 Ch 键功能化
标题:结合光有机氧化还原和酶催化促进不对称 Ch 键功能化
摘要:在这项研究中,我们将光有机氧化还原催化和生物催化相结合,实现了简单烷烃原料的不对称 C-H 键功能化.使用光有机催化剂蒽醌硫酸盐 (Sas) 将烷烃氧官能化为醛和酮.我们将这种光驱动反应与不对称酶促功能化相结合,以产生具有高达 99% Ee 的手性羟基腈,胺,酰基和 α-手性酮.此外,我们展示了官能团与醇,酯和羧酸的相互转化.转化可以作为并发串联反应进行.由于光催化步骤中产生的活性氧,我们确定底物的降解和生物催化剂的抑制是影响相容性的限制因素.这些不相容性通过反应工程解决,例如应用两相系统或催化剂的时间和空间分离.使用精选的 11 种起始烷烃,一种光有机催化剂和 8 种不同的生物催化剂,我们合成了 26 种产品,并在克级报告了模型化合物安息香和扁桃腈 > 97% Ee.
Doi:10.1002/ejoc.201801692

专利信息

专利号:US-7452994-B2
优先权日:2001-09-12
标 题 :Synthesis of enantiomerically pure amino-substituted fused bicyclic rings
发明人：MCEACHERN ERNEST J; BRIDGER GARY J; SKUPINSKA KRYSTYNA A; SKERLJ RENATO T; YANG WEN
权利人:ANORMED INC
摘要:This invention describes various processes for synthesis and resolution of racemic amino-substituted fused bicyclic ring systems. One process utilizes selective hydrogenation of an amino-substituted fused bicyclic aromatic ring system. An alternative process prepares the racemic amino-substituted fused bicyclic ring system via nitrosation. In addition, the present invention describes the enzymatic resolution of a racemic mixture to produce the (R)- and (S)-forms of amino-substituted fused bicyclic rings as well as a racemization process to recycle the unpreferred enantioner. Further provided by this invention is an asymmetric synthesis of the (R)- or (S)-enantiomer of primary amino-substituted fused bicyclic ring systems.

专利号:US-2023278959-A1
优先权日:2020-05-04
标题:Synthesis of Optically Active Indoline Derivatives Via Ruthenium(II)-Catalyzed Enantioselective C-H Functionalization
发明人：CUI XIN; LI ZHONG-YUAN; CHAMINDA LAKMAL HETTI HANDI
权利人:UNIV MISSISSIPPI STATE
摘要:Provided herein are a method of Ru(II)-catalyzed enantioselective synthesis of a cyclic compound and cyclic compounds formed therefrom. The method includes providing a precursor compound having an unfunctionalized C—H bond and activating the unfunctionalized C—H bond by reacting the precursor compound in the presence of co-catalysts including a Ru(II) arene complex and a chiral transient directing group (CTDG).

专利号:US-5574186-A
优先权日:1995-03-08
标 题 :Enantioselective synthesis of cyclic amino alcohols
发明人：BOUDREAU CHARLES; TILLYER RICHARD D; TSCHAEN DAVID M
权利人:MERCK & CO INC
摘要:There is disclosed a novel process for the enantioselective synthesis of chiral amino alcohols from keto oxime ethers, which are derived from cyclic ketones, via catalytic asymmetric reduction, employing oxazaborolidine-borane complex (OAB-BH 3 ). In this catalytic reduction process two chiral centers are created in a single step with high levels of stereoselectivity.

专利号:US-8084630-B2
优先权日:2007-05-31
标 题 :Process for the synthesis of ramelteon and its intermediates
发明人：KANSAL VINOD KUMAR; MISTRY DHIRENKUMAR N; VASOYA SANJAY L; RAFILOVICH MICHAL; MOHA-LERMAN ELENA BEN; LIFSHITZ-LIRON REVITAL
权利人:KANSAL VINOD KUMAR; MISTRY DHIRENKUMAR N; VASOYA SANJAY L; RAFILOVICH MICHAL; MOHA-LERMAN ELENA BEN; LIFSHITZ-LIRON REVITAL; TEVA PHARMA
摘要:The present invention provides processes and intermediates for the synthesis of ramelteon.

专利号:US-8759584-B2
优先权日:2007-12-14
标 题 :Synthesis of biguanidines and triazines, and biguanidino-aluminium complexes as intermediates
发明人：FORD MARK JAMES
权利人:FORD MARK JAMES; BAYER CROPSCIENCE AG
摘要:Compounds of formula (I) or salts thereof, n nin which R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , X and Y are defined as in claim 1 , can be prepared by a process characterized in that a compound of the formula (II) or a salt thereof,n n nis reacted to a compound of the formula (III) or a salt thereof,n n nand an aluminium(III) source, optionally, in the presence of a protic additive or solvent selected from the group consisting of alcohols or amines.n n The compounds (I) are suitable to be used for the preparation of heterocyclic compounds corresponding to (I) where the group Al(X)(Y) is replaced with an optionally substituted carbon atom, or s-triazine derivatives thereof.

专利号:US-2009281176-A1
优先权日:2007-11-01
标题:Process for the synthesis of ramelteon and its intermediates
发明人：KANSAL VINOD KUMAR; MISTRY DHIRENKUMAR N; VASOYA SANJAY L; PATEL RAKESH; JADAV ARPAN M
权利人:KANSAL VINOD KUMAR; MISTRY DHIRENKUMAR N; VASOYA SANJAY L; PATEL RAKESH; JADAV ARPAN M
摘要:A process for the preparation of ramelteon and intermediates useful in the process. The process suitable for industrial scale provides increased yield and/or greater purity with fewer process steps.