CAS: 24241-18-7; 2-Amino-3,5-Dibromopyrazine

相似化合物

21943-12-4 59489-71-3 957230-70-5

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CAS号5049-61-6 氨基吡嗪 | CAS号886860-50-0 2-氨基-5-碘吡嗪 | CAS号5049-61-6 氨基吡嗪 | CAS号59489-71-3 2-氨基-5-溴吡嗪 | CAS号90674-84-3 2-氨基-5-溴-3-哌啶基吡嗪 | CAS号875781-41-2 5-溴-3-((三甲基硅基)乙... | CAS号89641-34-9 2-氨基-5-溴-3-二甲氨基吡嗪 | CAS号89123-58-0 2,3-二氨基-5-溴吡嗪 | CAS号84539-07-1 3,5-二溴-N,N-二甲基氨基吡嗪 | CAS号21943-15-7 3,5-二溴-2-羟基吡嗪 | CAS号5900-13-0 2-氨基-5-溴-3-甲氧基吡嗪 | CAS号77112-66-4 2-氨基-5-溴-3-乙氧基吡嗪

2-氨基-5-溴吡嗪置于n-溴代丁二酰亚胺(Nbs)体系中,用 氯仿 用作溶剂,化学反应 6.5H,以91%的收率获得2-氨基-3,5-二溴吡嗪
参考文献:含1,2,3-三唑衍生物的吡嗪的设计,合成和分子对接研究
标题:含1,2,3-三唑衍生物的吡嗪的设计,合成和分子对接研究
摘要:在这里,我们论证了含有1,2,3-三唑衍生物(7A,7B,7C,7D,8A,8B,8C,8D和12A,12B,12C,12D的新型吡嗪的设计和合成),按照程序中所述,使用合成的各种化学药品,碱和催化剂,均具有出色的收率(78-92%).这种方法的开发简单,有效且易于处理.还开发了在用于酰胺和酯键形成的通用偶联剂下更温和的反应条件和更高的选择性.由(6A,6B,6C,6D)制备的酰胺偶联衍生物的合成与n-乙基哌嗪偶联得到(7A,7B,7C,7D)和吗啉得到(8A,8B,8C,8D)通过在二氯甲烷中使用1-[双(二甲基氨基)亚甲基]-1 H-1,2,3-三唑并[4,5-B ]吡啶3-氧化六氟磷酸盐(hatu)和n,N-二异丙基乙胺(dipea)在室温下10小时.通过在室温下在二氯甲烷(dcm)中使用n,N'-二环己基碳二亚胺和4-二甲基氨基吡啶,将衍生物(6A,6B,6C,6D)与醇(
Doi:10.1002/jhet.2736

专利信息

专利号:US-11926624-B2
优先权日:2018-06-29
标 题:Synthesis of coelenterazine synthesis intermediate
发明人：DUVVURU RAJAGOPALA REDDY
权利人:INT PAPER CO
摘要:Disclosed herein are synthesis methods for coelenterazine and intermediates. Also disclosed are articles including the coelenterazine and coelenterazine derivatives. Representative absorbent articles include disposable diapers and adult incontinence products.

专利号:US-11939332-B2
优先权日:2018-06-29
标题:Synthesis of coelenterazine
发明人：DUVVURU RAJAGOPALA REDDY; BHATT RAMA; KUMAR ANIL
权利人:INT PAPER CO
摘要:Disclosed herein are synthesis methods for coelenterazine. Also disclosed are articles including the coelenterazine and coelenterazine derivatives. Representative absorbent articles include disposable diapers and adult incontinence products.

专利号:WO-2021229605-A1
优先权日:2020-05-14
标 题 :Process for preparation of savolitinib and its intermediates
发明人：ORUGANTI SRINIVAS; SEN SAIKAT; SAMPATH MAGESH; AEDHUNURI ARUN; PATHIVADA DEEPIKA
权利人:Dr Reddys Laboratories Ltd
摘要:The present application relates to a process for preparation of chiral amine fragment (IV) of savolitinib. The present application also relates to a process for preparation of savolitinib using the chiral amine (IV), as prepared by the process of the present application. The present application also discloses new intermediates useful for the synthesis of savolitinib. The present application further relates to crystalline forms of savolitinib, namely AA1, formic acid solvate and AA2. The present application also relates to amorphous solid dispersion of savolitinib.

专利号:US-2021332044-A1
优先权日:2018-06-29
标题:Synthesis of coelenterazine synthesis intermediate

专利号:US-2020002344-A1
优先权日:2018-06-29
标题 :Synthesis of coelenterazine

专利号:KR-20240121904-A
优先权日:2019-05-08
标题:Synthesis of coelenterazine