专利号:WO-2024163733-A1 优先权日:2023-02-01 标题:Electrochemical synthesis with redox stable nucleotides 发明人:WU TIANDI; LACKEY JEREMY; LIN YANYOU; PITSCH STEFAN 权利人:TWIST BIOSCIENCE CORP 摘要:Provided herein are compositions, devices, systems and methods for constructing and storing polynucleotides encoding information with redox resistant bases. The compositions, devices, systems, and methods described herein provide for storage or synthesis of a library comprising a plurality of polynucleotides with one or more redox resistance bases. Further provided herein are methods to increase DNA synthesis yield and fidelity.
专利号:US-8790537-B2 优先权日:2008-06-09 标题:Process for the preparation of solid polymer electrolytes using ionic liquids 发明人:AHMAD SHAHZADA; AGNIHOTRY SUHASINI AVINASH; DEEPA MELEPURATH 权利人:AHMAD SHAHZADA; AGNIHOTRY SUHASINI AVINASH; DEEPA MELEPURATH; COUNCIL SCIENT IND RES 摘要:The present invention provides a process for the preparation of solid polymer electrolytes using ionic liquids useful for electrochromic devices or electrochromic windows, which used an insitu polymerized solid polymer electrolyte encompassing an ionic liquid. Therefore the electrolyte is free from leakage, corrosion, side reaction and moisture sensitivity. The synthesis of polymeric electrolyte comprising of Ionic liquid containing at least one of the anions selected from the group of trifluoromethylsulfonate (CF 3 SO 3 − ), bis(trifluoromethylsulfonyl)imide [(CF 3 SO 2 ) 2 N − ] and bis(perfluoroethylsulfonyl)imide [(C 2 F 5 SO 2 ) 2 N − ], while varying the alkyl chain of the imidazolium ring is described and a simple method for preparing Ionic liquids has also been discussed. A method for preparing substantially pure molten salts i.e. ionic liquids is also described. Another objective of the present invention is to provide an electrochromic device utilizing these systems.
专利号:WO-9925385-A1 优先权日:1997-11-17 标 题:A method of increasing nucleic acid synthesis with ultrasound 发明人:UNGER EVAN C; MCCREERY THOMAS; SADEWASSER DAVID 权利人:IMARX PHARMACEUTICAL CORP 摘要:The present invention is directed to a method of increasing nucleic acid synthesis in a cell comprising administering to the cell a therapeutically effective amount of ultrasound for a therapeutically effective time such that said administration of said ultrasound results in said increased nucleic acid synthesis. The nucleic acid sequence may comprise an endogenous sequence or an exogenous sequence.
专利号:US-2022323924-A1 优先权日:2021-03-24 标题:Electrochemical polynucleotide synthesis 发明人:LACKEY JEREMY; HABIBIAN MARYAM; LIN YANYOU 权利人:TWIST BIOSCIENCE CORP 摘要:Provided herein are compositions, devices, systems and methods for generation and use of biomolecule-based information for storage. Further provided are devices comprising addressable electrodes controlling polynucleotide synthesis (deprotection, extension, or cleavage, etc.) Further provided are compositions for low voltage deprotection of polynucleotides.
专利号:US-12357959-B2 优先权日:2018-12-26 标题:Highly accurate de novo polynucleotide synthesis 发明人:PECK BILL JAMES; NOE MARY; PITSCH STEFAN; WEISS PATRICK A 权利人:TWIST BIOSCIENCE CORP 摘要:Methods, systems, compositions, and devices for the manufacturing of high-quality building blocks, such as polynucleotides, are described herein. Processes described herein provide for efficient washing of residual reagents, solvents, or byproducts from previous synthetic steps to allow for the generation of polynucleotides with low error rates. Processes described herein also provide for reduction in deletion rates during chemical nucleic acid synthesis. Further, methods and devices described herein allow for the rapid construction and assembly of large libraries of highly accurate polynucleotides.
专利号:US-2023366125-A1 优先权日:2003-03-31 标 题:Compartmentalised combinatorial chemistry by microfluidic control 发明人:GRIFFITHS ANDREW DAVID; WEITZ DAVID A; LINK DARREN ROY; AHN KEUNHO; BIBETTE JEROME 权利人:HARVARD COLLEGE; RES & INNOVATION UK 摘要:The invention describes a method for the synthesis of compounds comprising the steps of: (a) compartmentalising two or more sets of primary compounds into microcapsules; such that a proportion of the microcapsules contains two or more compounds; and (b) forming secondary compounds in the microcapsules by chemical reactions between primary compounds from different sets; wherein one or both of steps (a) and (b) is performed under microfluidic control; preferably electronic microfluidic control The invention further allows for the identification of compounds which bind to a target component of a biochemical system or modulate the activity of the target, and which is co-compartmentalised into the microcapsules.