CAS: 5081-36-7; 3-Methoxy-4-Nitrobenzoic Acid

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CAS号185629-31-6 3-氟-4-硝基苯甲酸甲酯 | CAS号67-56-1 甲醇 | CAS号403-21-4 3-氟-4-硝基苯甲酸 | CAS号38512-82-2 5-甲基-2-硝基苯甲醚 | CAS号5081-37-8 3-甲氧基-4-硝基苯甲酸甲酯 | CAS号92241-87-7 3-甲氧基-4-硝基苯甲酰胺 | CAS号446-34-4 3-氟-4-硝基甲苯 | CAS号700-38-9 5-甲基-2-硝基苯酚 | CAS号67579-92-4 3-甲氧基-4-硝基苯甲酰氯 | CAS号80410-57-7 3-甲氧基-4-硝基苯甲醛 | CAS号5081-37-8 3-甲氧基-4-硝基苯甲酸甲酯 | CAS号148459-54-5 4-氨基-3-甲氧基苯甲醇4-... | CAS号41608-64-4 4-氨基-3-甲氧基苯甲酸甲酯 | CAS号90725-63-6 2-溴-1-(3-甲氧基-4-... | CAS号214778-10-6 3-(甲基氨基)-4-硝基苯甲酸 | CAS号211374-82-2 4-氨基-3-甲氧基苯甲酰胺 | CAS号190330-56-4 benzyl 4-amino-... | CAS号35387-92-9 4-碘-3-甲氧基苯甲酸甲酯 | CAS号89-39-4 1,4-二甲氧基-2-硝基苯 | CAS号80866-88-2 3-甲氧基-4-硝基苯甲醇

5-甲基-2-硝基苯甲醚置于偶氮二异丁腈,氧气,Cobalt(II) Diacetate Tetrahydrate,溶剂黄146,Sodium Bromide体系中,130.0 °C,1.2 Mpa 条件下,反应 1.5H,以57%的收率获得产物3-甲氧基-4-硝基苯甲酸
参考文献:取代苯甲酸类有机物的连续化合成方法
标题:取代苯甲酸类有机物的连续化合成方法
摘要:本发明提供了一种取代苯甲酸类有机物的连续化合成方法.该连续化合成方法包括:在催化剂和有机溶剂的存在下,将式(ⅰ)所示的有机物与氧气连续地输入连续化反应装置进行连续氧化反应,得到取代苯甲酸类有机物,并连续排出,取代苯甲酸类有机物具有式(ⅱ)所示结构.氧气为绿色试剂,且廉价易得,反应结束后不会产生大量的三废,体系易处理.使用连续化反应操作能够降低高浓度氧在批次反应中使溶剂闪蒸爆炸的风险.在同等氧化条件中,采用连续化制备工艺能够减少了氧气的逃逸,使氧气利用率大大增加,也简化了操作,提高了反应的安全性和取代苯甲酸类有机物的收率.

专利信息

专利号:WO-2020248278-A1
优先权日:2019-06-14
标题:Method for continuous synthesis of substituted benzoic-acid organic substance
发明人：HONG HAO; ZHANG ENXUAN; LU JIANGPING; LIU ZHIQING; LI CHAO; TANG YANG
权利人:JINLIN ASYMCHEM LABORATORIES CO LTD
摘要:The present invention provides a method for the continuous synthesis of a substituted benzoic-acid organic substance. The continuous synthesis method comprises: in the presence of catalyst and organic solvent, the organic matter represented by formula (I) and oxygen are continuously inputted to a continuous reaction apparatus for continuous oxidation reaction to obtain a substituted benzoic-acid organic substance, which is discharged continuously, the substituted benzoic-acid organic substance having the structure represented by formula (II). Oxygen is a green reagent and is inexpensive and readily available; a large amount of wastewater, waste gas, and solid waste is not generated after the reaction, and the system is easy to handle. The use of a continuous reaction operation can reduce the risk of flash distillation and explosion of solvent due to a high concentration of oxygen in a batch reaction. Under the same oxidation conditions, the continuous preparation process can reduce the escape of oxygen, greatly increasing the oxygen utilization rate and also simplifying the operation, improving the safety of the reaction and the yield of the substituted benzoic-acid organic substance.

专利号:US-10308595-B2
优先权日:2013-02-15
标 题:Albicidin derivatives, their use and synthesis
发明人：SUESSMUTH RODERICH; KRETZ JULIAN; SCHUBERT VIVIEN; PESIC ALEXANDER; HUEGELLAND MANUELA; ROYER MONIQUE; COCIANCICH STEPHANE; ROTT PHILIPPE; KERWAT DENNIS; GRAETZ STEFAN
权利人:UNIV BERLIN TECH
摘要:Antibiotically active compounds characterized by general formula (I), wherein X1, BB, BC, BD, BE and X2 are building blocks with D1, D2, D3, D4 or D5 being linkers which include carbon, sulphur, nitrogen, phosphor and/or oxygen atoms and which are covalently connecting the moities BA and BB, BB and BC, BC and BD, BD and BE and BE and BF, respectively, and wherein in particular the building block BC comprises an amino acid derivative. The compounds for use in a method of treatment of diseases, in particular for use in a method of treatment of bacterial infections are also disclosed.

专利号:US-7745490-B2
优先权日:2004-05-12
标题 :Substituted N-aryl benzamides and related compounds for treatment of amyloid diseases and synucleinopathies
发明人：SNOW ALAN D; NGUYEN BETH P; LAKE THOMAS P; CASTILLO GERARDO M; WEIGELE MANFRED
权利人:PROTEOTECH INC
摘要:Substituted n-aryl benzamides, related compounds and their pharmaceutically acceptable derivatives, their synthesis, pharmaceutical compositions containing them, and their use in the treatment of amyloid diseases, including Aβ amyloidosis, such as observed in Alzheimer's disease, IAPP amyloidosis, such as observed in type 2 diabetes, and synucleinopathies, such as observed in Parkinson's disease, and the manufacture of medicaments for such treatment are provided.

专利号:US-9217012-B2
优先权日:2009-04-08
标题 :Inhibitors of protein tyrosine phosphatases
发明人：ZHANG ZHONG-YIN; ZHANG SHENG
权利人:ZHANG ZHONG-YIN; ZHANG SHENG; UNIV INDIANA RES & TECH CORP
摘要:Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC-PTP. Also provided are methods of using the compounds and formulations containing the compounds. Also described is a fluorescence-tagged combinatorial library synthesis and screening method. And methods of using these compounds to effect enzyme activity both in cells and in vitro as well as method of using these compounds to treat diseases in human and animals.

专利号:RU-2126006-C1
优先权日:1993-07-29
标 题:Tricyclic diazepine vasopressin and oxytocin antagonists, method of their synthesis, pharmaceutical composition, method of treatment

专利号:EP-2968667-A1
优先权日:2013-03-14
标题:Peg-based adhesive phenylic derivatives and methods of synthesis and use