CAS: 56523-47-8; (R)-2-Phenylpyrrolidine

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CAS号700-91-4 5-苯基-3,4-二氢-2H-吡咯 | CAS号860640-20-6 (R)-1-((R)-2-me... | CAS号167642-19-5 (S)-(-)-4-nitro... | CAS号167642-29-7 (R)-N-trityl 2-... | CAS号445433-35-2 (1S,2S)-2-benzy... | CAS号445433-30-7 [2(1R),4R,5R]-4... | CAS号174311-02-5 (R)-n-b°C-2-苯基吡咯烷 | CAS号186249-76-3 (RS,E)-N-benzyl... | CAS号167642-27-5 (S)-(-)-4-amino... | CAS号700-91-4 5-苯基-3,4-二氢-2H-吡咯

5-苯基-3,4-二氢-2H-吡咯置于cp*ir(Biot-P-L)Cl,Masmtggqqmgrdqagitgtwynqlgstfivtagadgaltgtyesavgnaesryvltgrydsapatdgsgtalgwtvawknnyrnahsattwsgqyvggaearintqwlltsgtteanawkstlvghdtftkvkpsaasidaakkagvnngnpldavqqgsgggngggngggngggnidgrgggnasmtggqqmgrdqagitgtwynqlgstfivtagadgaltgtyvtargnaesryvltgrydsapatdgsgtalgwtvawknnyrnahsattwsgqyvggaearintqwlltagtteanawastlvgcdtftkvkpsaasidaakkagvnngnpldavqq体系中,用 二甲基亚砜 作为反应溶剂,化学反应 48.0H,以97%的收率获得产物
参考文献:打破对称性:工程化单链二聚链霉亲和素作为人工金属酶的宿主
标题:打破对称性:工程化单链二聚链霉亲和素作为人工金属酶的宿主
摘要:生物素-链霉亲和素技术已被广泛用于设计可催化十几种不同反应的人工金属酶 (Arm).尽管具有多功能性,链霉亲和素 (Sav) 的同源四聚体性质和生物素化辅因子的非合作结合对 Arm 的遗传优化施加了两个限制:(I) 点突变反映在 Sav 的所有四个亚基中,以及 (II) 非合作结合生物素化辅因子对 Sav 的影响可能会导致催化性能下降,这取决于辅因子:生物素结合位点的比例.为了应对这些挑战,我们报告了我们努力设计(单价)单链二聚链霉亲和素 (Scdsav) 作为基于 Sav 的 Arms 支架的努力.使用 [cp*ir(Biot-Pl)Cl] 作为辅因子对前手性亚胺进行不对称转移氢化,突出了 Scdsav 作为宿主蛋白的多功能性.通过对生物素结合前庭进行更精确的遗传微调,在减少具有挑战性的前手性亚胺方面实现了无与伦比的活性和选择性水平.[cp*ir(Biot-Pl)Cl].scdsav 与结构相关的
DOI:10.1021/jacs.9B06923

专利信息

专利号:US-9434968-B2
优先权日:2009-06-22
标题:Transaminase reactions
发明人：HUGHES GREGORY; DEVINE PAUL N; FLEITZ FRED J; GRAU BRENDAN T; LIMANTO JOHN; SAVILE CHRISTOPHER; MUNDORFF EMILY
权利人:CODEXIS INC
摘要:The present disclosure relates to methods of using transaminase polypeptides in the synthesis of chiral amines from prochiral ketones.

专利号:US-9695191-B2
优先权日:2009-08-05
标题 :Conformationally constrained, fully synthetic macrocyclic compounds
发明人：OBRECHT DANIEL; ERMERT PHILIPP; OUMOUCH SAID; LACH FRANCK; LUTHER ANATOL; MARX KARSTEN; MÖHLE KERSTIN
权利人:OBRECHT DANIEL; ERMERT PHILIPP; OUMOUCH SAID; LACH FRANCK; LUTHER ANATOL; MARX KARSTEN; MÖHLE KERSTIN; POLYPHOR AG
摘要:Conformationally restricted, spatially defined 12-30 membered macrocyclic ring systems of type (I) are constituted by three distinct building blocks: an aromatic template a, a conformation modulator b and a spacer moiety c as detailed in the description and the claims. Macrocycles of type (I) are readily manufactured by parallel synthesis or combinatorial chemistry. They are designed to interact with specific biological targets. In particular, they show agonistic or antagonistic activity on the motilin receptor (MR receptor), on the serotonin receptor of subtype 5-HT 2B (5-HT 2B receptor), and on the prostaglandin F2•receptor (FP receptor). They are thus potentially useful for the treatment of hypomotility disorders of the gastrointestinal tract such as diabetic gastroparesis and constipation type irritable bowl syndrome; of CNS related diseases like migraine, schizophrenia, psychosis or depression; of ocular hypertension such as associated with glaucoma and preterm labour.