CAS: 587-88-2; Ethyl 2-(4-Fluorophenyl)Acetate

上下游产品

ethanol p-Fluorophenylacetic acid ethyl 3-phenyl-2-propenoate 2-(4-fluorophenyl)acetamide (4-fluoro-phenyl)-acetic acid-(2-hydroxy-ethylamide) tris-(4-fluoro-phenyl)-ethene ethyl α-formyl-4-fluorophenylacetate 2-(4-fluorophenyl)-3-oxo-3,4-dihydro-2H-1,4-benzothiazine

4-氟苯乙酸置于草酰氯,N,N-二甲基甲酰胺体系中,用 四氢呋喃 作为反应溶剂,化学反应 0.17H,反应生成 对氟苯乙酸乙酯
参考文献:羟烷基叠氮化物与酮的施密特反应中的异常束缚效应:阳离子-π 和伪轴苯基的空间稳定
标题:羟烷基叠氮化物与酮的施密特反应中的异常束缚效应:阳离子-π 和伪轴苯基的空间稳定
摘要:路易斯酸促进的手性 2-芳基-3-叠氮基-1-丙醇与 4-取代环己酮的反应反应生成亚胺醚并最终反应生成己内酰胺(在水解步骤之后).在这项研究中,表明这些反应提供了可变比例的产物,这取决于苯基的电子性质.这些结果在决定产物的反应中间体中阳离子-π 稳定作用的背景下进行解释.值得注意的是,当使用含有季铵盐中心的叠氮基丙醇试剂时,选择性最佳;对照实验表明,在该结果中观测到的高选择性取决于提供主要产物的中间体中假轴芳基的自由旋转.
DOI:10.1021/ja0382361

专利信息

专利号:US-4426536-A
优先权日:1982-06-14
标 题:Synthesis of phenylacetic acid esters
发明人：ROBEY ROGER L
权利人:LILLY CO ELI
摘要:Esters of phenylacetic acids are prepared in a single step by hydrolysis of 2,2,2-trichloro-1-phenylethanes in inorganic basic media.

专利号:DE-102012224021-A1
优先权日:2012-05-09
标 题 :A process for the synthesis of phenylacetic acid by carbonylation of toluene

专利号:JP-2013234166-A
优先权日:2012-05-09
标 题 :Synthesis of phenylacetic acid by carbonylation of toluene

专利号:US-6992097-B2
优先权日:1998-08-18
标 题 :Growth hormone secretagogues
发明人：HAUSER KENNETH LEE; DODGE JEFFREY ALAN; HEIMAN MARK LOUIS; JONES SCOTT ALAN; ALT CHARLES ARTHUR; BRYANT HENRY UHLMAN; COHEN JEFFREY DANIEL; COPP JAMES DENSMORE; FAHEY KENNAN JOSEPH; GRITTON WILLIAM HARLAN; JUNGHEIM LOUIS NICKOLAUS; KENNEDY JOSEPH HENRY; LUGAR III CHARLES WILLIS; MUEHL BRIAN STEPHEN; PALKOWITZ ALAN DAVID; RATZ ANDREW MICHAEL; RHODES GARY ANTHONY; ROBEY ROGER LEWIS; SEYLER DAVID EDWARD; SHEPHERD TIMOTHY ALAN; THRASHER KENNETH JEFF; TRANKLE WILLIAM GEORGE
权利人:LILLY CO ELI
摘要:This invention relates to novel compounds which are useful in the modulation of endogenous growth hormone levels in a mammal. The invention further relates to novel intermediates for use in the synthesis of said compounds, as well as novel processes employed in these syntheses. Also included are methods of treating a mammal which include the administration of said compounds.

专利号:EP-0098058-A1
优先权日:1982-06-14
标 题 :Synthesis of phenylacetic acid esters

专利号:GB-2121798-A
优先权日:1982-06-14
标 题:Synthesis of phenylacetic acid esters