CAS: 622-95-7; 1-(Bromomethyl)-4-Chlorobenzene

上下游产品

brom°Cyane (4-bromo-benzyl)-(4-chloro-benzyl)-methyl-amine (4-chloro-benzyl)-methyl-(4-nitro-benzyl)-amine (4-chloro-benzyl)-methyl-(3-nitro-benzyl)-amine 2-(4-chlorobenzyl)pyridine N-(4-chlorobenzyl)-pyridinium bromide N-(4-chlorobenzyl)-2-(piperidin-1-yl)ethan-1-amine (4-chloro-benzyl)-(3-piperidino-propyl)-amine

4-氯苯甲醇置于氢溴酸体系中,化学反应生成 4-氯苄溴
参考文献:新型嘌呤-三唑杂合体作为潜在的抗乳腺癌药物:合成,抗增殖活性和 Admet 计算机研究
标题:新型嘌呤-三唑杂合体作为潜在的抗乳腺癌药物:合成,抗增殖活性和 Admet 计算机研究
摘要:以苄基叠氮化物和嘌呤炔为原料,通过 Cu(I) 催化的 1,3-偶极环加成反应,以相当高的收率(高达 87%)合成了两个系列的新型 1,2,3-三唑-嘌呤杂化物.第一个 (7A-K)和第二个 (8A-K)系列杂交体分别采用激动素和腺嘌呤作为前体.所有合成的化合物均在体外评估其针对两种乳腺癌细胞系(mcf-7 和 Mda-Mb-231)和非肿瘤细胞系(mcf-10A)的抗增殖活性,以估计其选择性.从 22 种合成化合物中,有 8 种(4,7A-E,7 H和8A)对两种肿瘤细胞系都有活性,尤其是激动素衍生物,其效果比腺嘌呤衍生物更好.原始的激动素分子没有活性,表明其衍生物的结构变化有利于在测试细胞中诱导细胞毒性作用.化合物7C和7D活性最强,Mcf-7的ic 50分别为22.3 µm和22.9 µm,Mda-Mb-231的ic 50分别为9.3 µm和16.7 µm.此外,Admet
DOI:10.1007/s00044-023-03115-W

专利信息

专利号:US-7102023-B2
优先权日:1999-11-24
标 题:Protecting groups useful in the synthesis of polysaccharides, natural products, and combinatorial libraries
发明人：BUCHWALD STEPHEN L; PLANTE OBADIAH J; SEEBERGER PETER H
权利人:MASSACHUSETTS INST TECHNOLOGY
摘要:One aspect of the present invention relates to optionally substituted halogenated benzyl halides and the like. These compounds are useful as halogenated benzyl ether-based protecting groups for a variety of functional groups. Another aspect of the present invention relates to use of said protecting groups in an orthogonal protecting group strategy for the synthesis of complex molecules that comprise a number of suitable functional groups. Another aspect of the present invention relates to saccharides bearing various arrays of protecting groups of the present invention. Another aspect of the present invention relates to a method of synthesizing an oligosaccharide or glycoconjugate, comprising the steps of: using a saccharide bearing at least one protecting group of the present invention to glycosylate a second molecule to give a product comprising said saccharide; and removing a protecting group of the present invention from said product.

专利号:US-2025026768-A1
优先权日:2023-06-30
标题:Method for the synthesis of axially chiral organoboron compounds
发明人：PING YIFAN; CHE CHI-MING
权利人:LABORATORY FOR SYNTHETIC CHEMISTRY AND CHEMICAL BIOLOGY LTD
摘要:A highly efficient and atroposelective Rh-catalyzed [2+2+2] cycloaddition for the synthesis of axially chiral aryboron compounds is developed. The reactions of diynes and alkynylborons smoothly occur in an atom-economical manner, affording a variety of C—B atropisomers in excellent yields and enantioselectivities. The protocol features mild conditions, broad substrate scope, and good functional tolerance. The obtained C—B atropisomers show powerful synthetic applications in terms of producing novel chiral phosphine ligands.

专利号:US-5554753-A
优先权日:1993-08-25
标 题:Catalytic enantioselective synthesis of α-amino acid derivatives by phase-transfer catalysis
发明人：O'DONNELL MARTIN J; WU SHENGDE; ESIKOVA IRENA; MI AIQIAO
权利人:INDIANA UNIVERSITY FOUNDATION
摘要:Described are improved processes for the enantioselective synthesis of α-amino acids which involve combinations of solvents, highly-mixed and low-temperature reaction conditions, and novel catalysts. Also described are novel catalysts and precursors to α-amino acid derivatives.

专利号:US-9556140-B2
优先权日:2013-01-26
标 题 :Approach for synthesis of catechins
发明人：DUGAR SUNDEEP; MAHAJAN DINESH; RAI KUMAR SANTOSH; TRIPATHI VINAYAK; PATIL ISHWAR RAKESH
权利人:SPHAERA PHARMA PRIVATE LTD
摘要:A process for synthesis of enatiomerically pure or enatiomerically enriched or racemic mixture of (+ and/or −) epicatechin and its intermediates, comprising the steps of: (i) obtaining penta-protected quercetin; (ii) reducing the penta-protected quercetin obtained from step (i); (iii) optionally deprotecting the compound of step (ii); (iv) reducing the compound obtained from step (ii) or step (iii) in the presence of a chiral/achiral reducing agent to obtain a chiral intermediate; (v) deprotecting and/or hydrogenation of the chiral intermediate obtained from step (iv) to obtain (−)-epicatechin; (vi) optionally simultaneously deprotecting and by drogenation of the compound obtained from step (ii) to obtain racemic epicatechin.

专利号:US-6455680-B1
优先权日:2000-12-21
标 题 :Methods utilizing aryl thioimines in synthesis of erythromycin derivatives
发明人：LUKIN KIRILL A
权利人:ABBOTT LAB
摘要:An efficient deoximation technique for use in synthesis of erythromycin derivatives, involving aryl thioimine intermediates is disclosed. The aryl thioimine intermediates can be utilized in a method for protecting a ketone of a ketone-containing erythromycin derivative as a thioimine; a method for deoximating an oxime-containing erythromycin derivative, or a method for preparing a 6-O-alkyl erythromycin derivative. Presently preferred erythromycin derivatives have a C-9 oxime or a C-9 ketone.

专利号:US-9428482-B2
优先权日:2011-01-27
标 题 :Process for synthesis of polyphenols
发明人：DUGAR SUNDEEP; MAHAJAN DINESH; PANTELIS PETER GIANNOUSIS; SINGH VIJAY; KAPOOR KAMAL KISHORE
权利人:DUGAR SUNDEEP; MAHAJAN DINESH; PANTELIS PETER GIANNOUSIS; SINGH VIJAY; KAPOOR KAMAL KISHORE; SPHAERA PHARMA PTE LTD
摘要:The present invention provides synthetic processes for preparing racemic and/or optically pure epicatechin, epigallocatechin and related polyphenols as such or as their variously functionalized derivatives. A principle objective of the disclosure is to provide a new and useful method of synthesis to obtain polyphenols in isomerically pure and/or racemic forms.