乙酸丁酯置于bismuth(III) Bromide 三甲基溴硅烷体系中,用 Neat (No Solvent) 用作溶剂,化学反应 2.25H,以90%的收率获得正溴丁烷 参考文献:Labrouillere,Mireille; Roux,Christophe Le; Oussaid,Abdelouahad,Bulletin De La Societe Chimique De France,1995,Vol. 132,P. 522-530 标题:Labrouillere,Mireille; Roux,Christophe Le; Oussaid,Abdelouahad,Bulletin De La Societe Chimique De France,1995,Vol. 132,P. 522-530
专利号:US-8084007-B2 优先权日:2004-01-30 标题 :Methods of synthesis of isotropically enriched borohydride and methods of synthesis of isotropically enriched boranes 发明人:SPIELVOGEL BERNARD; COOK KEVIN S 权利人:SPIELVOGEL BERNARD; COOK KEVIN S; SEMEQUIP INC 摘要:The invention provides new methods for the synthesis of isotopically enriched metal borohydrides, metal tetrahydroundecaborate salts, and decaborane from isotopically enriched 10 B-boric acid or 11 B-boric acid. The invention is particularly useful for synthesis of isotopically enriched sodium or lithium borohydride, MB 11 H 14 (where M is Li, Na, K, or alkylammonium), and decaborane.
专利号:WO-2013091696-A1 优先权日:2011-12-21 标题 :Synthesis of intermediates for preparing anacetrapib and derivatives thereof 发明人:HUMLJAN JAN; MARAS NENAD 权利人:LEK PHARMACEUTICALS; HUMLJAN JAN; MARAS NENAD 摘要:The present invention relates to the field of organic chemistry, more specifically to the synthesis of intermediate compounds which can be used in the synthesis of pharmaceutically active agents such as anacetrapib or derivatives thereof.
专利号:EP-2468735-A1 优先权日:2010-12-23 标 题:Synthesis of intermediates for preparing anacetrapib and derivates thereof 权利人:LEK PHARMACEUTICALS 摘要:The present invention relates to the field of organic chemistry, more specifically to the synthesis of intermediate compounds which can be used in the synthesis of pharmaceutically active agents such as anacetrapib or derivatives thereof.
专利号:US-6951932-B2 优先权日:2001-10-25 标 题:Synthesis of 2-aralkoxyadenosines and 2-alkoxyadenosines 发明人:MOORMAN ALLAN R 权利人:KING PHARMACEUTICALS RES & DEV 摘要:The invention provides new methods for synthesis of 2-aralkyloxyadenosines and 2-alkoxyadenosines. The invention is particularly useful for synthesis of 2-[2-(4-chlorophenyl)ethoxy]adenosine. Preferred methods of the invention include activating a guanosine compound followed by hydrolysis; alkylating the hydrolyzed compound with subsequent animation to provide a 2-aralkyloxyadenosine or a 2-alkoxyadenosine compound.
专利号:US-5248815-A 优先权日:1991-12-27 标 题 :Stereo-selective synthesis of 2-aryl-propionic acids of high optical purity by using chiral oxazolines 发明人:PARADIES HENRICH H 权利人:PARADIES HENRICH H 摘要:The present invention relates to a stereospecific chemical synthesis of optically pure enantiomers of 2-aryl-alkanoic acids, especially those of the biologically active (S)-aryl-propionic acids, in good chemical yields, useful for preparing large quantities thereof, and having a high optical purity.
专利号:WO-2023148680-A1 优先权日:2022-02-04 标 题 :Methods for large scale synthesis of radionuclide complexes 发明人:BARBATO DONATO; BO MICHELE; ROSSETTO MATTIA; TEDESCO MATTIA; VALERIO FEDERICO 权利人:ADVANCED ACCELERATOR APPLICATIONS 摘要:The present disclosure relates to methods of large scale synthesis of radionuclide complex solutions having a high activity for diagnostic and/or therapeutic purposes, their use in the commercial production of radioactive drug substances, and to respective solutions as well as containers comprising said solutions.