双(二乙胺)苯膦置于三乙胺体系中,用 乙醚 用作溶剂,化学反应生成苯基膦酸二乙酯 参考文献:Andreev,N.A.; Grishina,O.N.,Journal Of General Chemistry Of The Ussr,1979,Vol. 49,P. 1959-1964 标题:Andreev,N.A.; Grishina,O.N.,Journal Of General Chemistry Of The Ussr,1979,Vol. 49,P. 1959-1964
专利号:WO-2025082632-A1 优先权日:2023-10-16 标 题:Method and composition for oligonucleotide synthesis 发明人:SAITO MASAHARU 权利人:BACHEM HOLDING AG 摘要:The invention pertains to a method for the synthesis of oligonucleotides using pseudo solid-phase protecting groups, wherein said method comprises a step of subjecting a solution comprising a component (C-0)# to one or more aqueous extractions, wherein the organic phase comprises the component (C-0)#. Said component (C-0)# is a nucleoside or an oligonucleotide, which is covalently bonded to a pseudo solid-phase protecting group and comprises a free backbone hydroxyl group. The aqueous phase of each of said one or more aqueous extractions has a pH-value in the range of 4-7.
专利号:EP-4605403-A1 优先权日:2022-10-17 标 题:Method and composition for oligonucleotide synthesis 发明人:SAITO MASAHARU; TAKEDA KAZUTAKA; OKADA YOHEI; LUTHER ANATOL 权利人:BACHEM HOLDING AG 摘要:The invention pertains to methods for the synthesis of oligonucleotides using pseudo solid-phase protecting groups, wherein said method comprises at least one aqueous extraction carried out in the presence of one or more amide solvents SA, wherein each amide solvent SA is an amide solvent comprising one or more alkyl groups, wherein these one or more alkyl groups together comprise in total 6−24 carbon atoms. The invention further pertains to compositions comprising an oligonucleotide which is covalently bonded to a pseudo solid-phase protecting group and a mixed solvent comprising on or more of the aforementioned amide solvents SA.
专利号:WO-2024083746-A1 优先权日:2022-10-17 标 题 :Method and composition for oligonucleotide synthesis 发明人:SAITO MASAHARU; TAKEDA KAZUTAKA; OKADA YOHEI; LUTHER ANATOL 权利人:BACHEM HOLDING AG 摘要:The invention pertains to methods for the synthesis of oligonucleotides using pseudo solid-phase protecting groups, wherein said method comprises at least one aqueous extraction carried out in the presence of one or more amide solvents SA, wherein each amide solvent SA is an amide solvent comprising one or more alkyl groups, wherein these one or more alkyl groups together comprise in total 6−24 carbon atoms. The invention further pertains to compositions comprising an oligonucleotide which is covalently bonded to a pseudo solid-phase protecting group and a mixed solvent comprising on or more of the aforementioned amide solvents SA.
专利号:US-3992456-A 优先权日:1969-04-16 标题:Synthesis of alkadienols 发明人:ATKINS KENNETH EARL; MANYIK ROBERT MICHAEL; O'CONNOR GEORGE LAWRENCE 权利人:UNION CARBIDE CORP 摘要:Alkadienols are prepared by reacting a conjugated diolefin, such as butadiene, with water in the presence of palladium or platinum catalyst and in the presence of solvents. The addition of carbon dioxide to the reaction mixture greatly increases the yield of alkadienols. The products can be hydrogenated to saturated alcohols, useful for making plasticizers.
专利号:US-3711534-A 优先权日:1968-09-04 标题 :Synthesis of octadienyl esters 发明人:MANYIK R; WALKER W 权利人:UNION CARBIDE CORP 摘要:OCTADIENYL ESTERS ARE PREPARED BY REACTING BUTADIENE WITH CARBOXYLIC ACIDS IN THE PRESENCE OF PALLADIUM CATALYSTS, PREFERABLY COMPLEXED WITH PHOSPHITE OR PHOSPHINE LIGANDS, AND TERTIARY AMINES HAVING A BASICITY CONSTANT KB GREATER THAN 10**-7 AS REACTION MODIFIERS. THE TERTIARY AMINES ALSO ASSIST IN THE SEPARATION OF THE PRODUCTS.
专利号:US-12071507-B2 优先权日:2014-01-10 标 题:Method and composition for improving adhesion of metathesis compositions to substrates 发明人:STEPHEN ANTHONY R; CRUCE CHRISTOPHER J; TRIMMER MARK S; GIARDELLO MICHAEL A 权利人:MATERIA INC 摘要:A method of improving the adhesion of metathesis compositions, such as ring-opening metathesis polymerization (ROMP) compositions, to a substrate is disclosed, in which an adhesion promoter is added to a polymerizable resin composition in order to improve the adhesion of the polymerizing resin to a substrate material. The addition of the adhesion promoter has been found to provide beneficial improvements in the adhesion of metathesis, especially ROMP, compositions to substrates, particularly glass surfaces, leading to improved characteristics in ROMP materials formed therefrom. The adhesion promoter generally comprises a functionalized silane compound and a peroxide compound. A ROMP composition is further disclosed comprising a cyclic olefin, a ROMP metathesis catalyst, and the adhesion promoter. Polymer products produced via metathesis (ROMP) reactions of the invention may be utilized to provide a wide range of materials and in a variety of composite applications. The invention has utility in the fields of catalysis, organic synthesis, and polymer and materials chemistry and manufacture.