CAS: 1665-00-5; Dichloromethane-D2

上下游产品

CAS号865-49-6 氘代氯仿-d | CAS号758-12-3 乙酸-D{1} | CAS号3017-23-0 Hydr°Cyanic acid-d | CAS号1665-01-6 二氯甲烷-d | CAS号506-77-4 氯化氰 | CAS号14243-64-2 三苯基膦氯金 | CAS号676-55-1 甲烷-d2 | CAS号994-30-9 三乙基氯硅烷 | CAS号15729-58-5 二碘甲烷-d2 | CAS号7698-05-7 氘代盐酸

氘代氯仿,乙酸-D1置于锌体系中,化学反应生成二氯甲烷-D2
参考文献:The Microwave Spectra,Structure,Dipole Moment,And Chlorine Nuclear Quadrupole Coupling Constants Of Methylene Chloride
标题:The Microwave Spectra,Structure,Dipole Moment,And Chlorine Nuclear Quadrupole Coupling Constants Of Methylene Chloride
摘要:The Microwave Spectra Of Ch2Cl235,Ch2Cl35Cl37,Ch2Cl237,Cdhcl235,Cdhcl35Cl37,Cd2Cl235,And Cd2Cl35Cl37 Have Been Examined And Effective Moments Of Inertia Have Been Determined For These Seven Isotopic Species. From These Data The Effective Bond Distances And Angles Were Determined As C-cl Distance=1.7724+/-0.0005A,Cl-c-cl Angle=111°47'+/-1',C-h Distance=1.068+/-0.005A (Average Of All Species),Or 1.082A (Extrapolated To Infinite Hydrogen Mass),And H-c-h Angle=112°0'+/-20' (Average Of All Species) Or 112°58' (Extrapolated To Infinite Hydrogen Mass). The Best Value For The Dipole Moment Of Methylene Chloride Was Found From The Stark Splitting To Be 1.62+/-0.02x10−18 Esu. The Chlorine Nuclear Quadrupole Coupling Constants Were Also Determined And Their Relationship To The Structure Is Discussed.
Doi:10.1063/1.1700773

专利信息

专利号:US-6504041-B2
优先权日:1996-11-15
标题 :Synthesis of ruthenium or osmium metathesis catalysts
发明人：GRUBBS ROBERT H; BELDERRAIN TOMAS R; BROWN SETH N; WILHELM THOMAS E
权利人:CALIFORNIA INST OF TECHN
摘要:The present invention relates to the synthesis of highly active ruthenium and osmium carbene metathesis catalyst in good yield from readily available starting materials. The catalysts that may be synthesized are of the general formula n wherein: n M is ruthenium or osmium; n X and X 1 are independently any anionic ligand; n L and L 1 are any neutral electron donor ligand; and, n R and R 1 are each hydrogen or one of the following substituent groups: C 2 -C 20 alkenyl, C 2 -C 20 alkynyl, C 1 -C 20 alkyl, aryl, C 1 -C 20 carboxylate, C 1 -C 20 alkoxy, C 2 -C 20 alkenyloxy, C 2 -C 20 alkynyloxy, aryloxy, C 2 -C 20 alkoxycarbonyl, C 1 -C 20 alkylthio, C 1 -C 20 alkylsulfonyl and C 1 -C 20 alkylsulfinyl. Optionally, the substituent group may be substituted with one or more groups selected from C 1 -C 5 alkyl, halogen, C 1 -C 5 alkoxy, and aryl. When the substitute aryl group is phenyl, it may be further substituted with one or more groups selected from a halogen, a C 1 -C 5 alkyl, or a C 1 -C 5 alkoxy. Specific synthetic protocols for vinyl alkylidene catalysts wherein R is hydrogen and R 1 is —CHCR 12 R 13 and non-vinyl alkylidene catalysts are also disclosed. In addition to the ease of synthesis (typically a one-step synthesis), the reactions generally may be run at or above room temperature and the resulting products usually may be used without extensive post synthesis purification.

专利号:US-6683189-B1
优先权日:1996-02-26
标 题 :Method for the synthesis of pyrrole and imidazole carboxamides on a solid support
发明人：DERVAN PETER B; BAIRD ELDON
权利人:CALIFORNIA INST OF TECHN
摘要:The present invention describes a novel method for the solid phase synthesis of polyamides containing imidazole and pyrrole carboxamides. The polyamides are prepared on a solid support from aromatic carboxylic acids and aromatic amines with high stepwise coupling yields (>99%), providing milligram quantities of highly pure polyamides. The present invention also describes the synthesis of analogs of the natural products Netropsin and Distamycin A, two antiviral antibiotics. The present invention also describes a novel method for the solid phase synthesis of imidazole and pyrrole carboxamide polyamide-oligonucleotide conjugates. This methodology will greatly increase both the complexity and quantity of minor-groove binding polyamides and minor-groove binding polyamide-oligonucleotide conjugates which can be synthesized and tested.

专利号:US-6479685-B2
优先权日:1998-01-09
标题 :Metallocene catalysts for synthesis of high-melting polyolefin copolymer elastomers
发明人：WAYMOUTH ROBERT M; KRAVCHENKO RAISA L; MACIEJEWSKI PETOFF JENNIFER; HUNG JOYCE
权利人:TRUSTEES OF THE LELAND STANDAR
摘要:Metallocene catalysts having plural coordination geometries for synthesis of high melting polyolefin copolymers suitable as thermoplastic elastomers. The inventive catalysts comprise unbridged, substituted or unsubstituted cyclopentadienyl metallocene catalysts that are capable of inter-converting between states with different polymerization or copolymerization characteristics, which interconversion is controlled by selecting the substituents of the cyclopentadienyl ligands so that the rate of interconversion of the two states is within several orders of magnitude of the rate of formation of a single polymer chain. Where r i >r f the polymer can be characterized as multiblock; where r i
专利号:US-11548898-B2
优先权日:2017-07-06
标题 :Synthesis of halichondrins
发明人：KISHI YOSHITO; AI YANRAN; YE NING; WANG QIAOYI; YAHATA KENZO; ISO Kentaro; NAINI SANTHOSH REDDY; YAMASHITA SHUJI; LEE JIHOON; OHASHI ISAO; FUKUYAMA TAKASHI
权利人:HARVARD COLLEGE; EISAI R&D MAN CO LTD
摘要:The present invention provides methods for the synthesis of ketones involving a Ni/Zr-mediated coupling reaction. The Ni/Zr-mediated ketolization reactions can be used in the synthesis of halichondrins (e.g., halichondrin A, B, C; homohalichondrin A, B, C; norhalichondrin A, B, C), and analogs thereof. Therefore, the present invention also provides synthetic methods useful for the synthesis of halichondrins, and analogs thereof. Also provided herein are compounds (i.e., intermediates) useful in the synthesis of halichondrins, and analogs thereof. In particular, the present invention provides methods and compounds useful in the synthesis of compound of Formula (H3-A).

专利号:WO-2024012791-A1
优先权日:2022-07-11
标题 :Electrochemical synthesis of pyrazolines and pyrazoles
发明人：BÄR ROBIN MAXIMILIAN; FORD MARK JAMES; KALDAS SHERIF JAMES; WALDVOGEL SIEGFRIED; HOFMANN SILJA; LINDEN MARTIN
权利人:BAYER AG
摘要:The present invention relates to an electrochemical process for the synthesis of pyrazolines and pyrazoles of formula (I). The process can be especially used for the synthesis of the herbicide safener mefenpyr-diethyl.

专利号:WO-2012047907-A9
优先权日:2010-10-04
标题 :Synthesis of c5-substituted tetracyclines, uses thereof, and intermediates thereto
发明人：MYERS ANDREW G; WRIGHT PETER M; HECKER EVAN
权利人:HARVARD COLLEGE; MYERS ANDREW G; WRIGHT PETER M; HECKER EVAN
摘要:The tetracycline class of antibiotics has played a major role in the treatment of infectious diseases for the past 50 years. However, the increased use of the tetracyclines in human and veterinary medicine has led to resistance among many organisms previously susceptible to tetracycline antibiotics. The recent development of a modular synthesis of tetracycline analogs through a chiral enone intermediate has allowed for the efficient synthesis of novel tetracycline analogs never prepared before. The present invention provides more efficient routes for preparing the enone intermediate and allows for a wide variety of substituents at position 5 of the tetracycline ring system.