CAS: 199336-83-9; Tert-Butyl (R)-3-(Methylamino)Pyrrolidine-1-Carboxylate

相似化合物

122536-76-9 122536-77-0 131878-23-4

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CAS号1004538-35-5 (R)-1-B°C-3-(Me...

Tert-Butyl (3R)-3-{[(2-Nitrophenyl)Sulfonyl]Amino}Pyrrolidine-1-Carboxylate置于potassium Carbonate体系中,用 N,N-二甲基甲酰胺,乙腈 用作溶剂,化学反应 17.0H,反应生成(R)-3-(甲基氨基)吡咯烷-1-甲酸叔丁酯
参考文献:发现了一种新型的双环化合物ds54360155,它是一种口服有效的止痛药,没有mu阿片类受体激动剂活性.
标题:发现了一种新型的双环化合物ds54360155,它是一种口服有效的止痛药,没有mu阿片类受体激动剂活性.
摘要:我们合成了天然生物碱,可可定的衍生物,并在口服后在ddy小鼠中的乙酸诱导的扭体试验和福尔马林试验中评估了这些衍生物.结果,我们确定了(5 S)-6-甲基-1,3,4,5,6,8-六氢-7H-2,5-甲基[1,5]重氮基[7,8-B]吲哚-7-硫酸盐15A(ds54360155)具有独特的原始双环骨架,比可可啶具有更强的镇痛作用.此外,15A没有表现出μ阿片受体激动剂活性.
Doi:10.1016/j.Bmcl.2019.126748

专利信息

专利号:US-8030501-B2
优先权日:2006-07-28
标题 :Process for producing optically active 3-amino nitrogen-containing compounds
发明人：OHNUKI MASATOSHI; IZUMIDA MASASHI; NISHIYAMA AKIRA; MATSUMOTO SHINGO
权利人:KANEKA CORP
摘要:Aiming at production of an optically active 3-amino nitrogen-containing compound which is useful as an intermediate in synthesis of medicines and pesticides, in particular, an optically active 1-protected-3-aminopyrrolidine derivative, from an inexpensive and readily available raw material by a process which is efficient and can be practiced industrially, an optically active 3-amino nitrogen-containing compound is produced by performing a reaction of an optically active 3-substituted nitrogen-containing compound with ammonia, methylamine, ethylamine or dimethylamine in the presence of water. In addition, a 1-protected-3-aminopyrrolidine derivative is produced by performing a reaction of an optically active 1-protected-3-(sulfonyloxy)pyrrolidine derivative with ammonia, methylamine, ethylamine, or dimethylamine in the presence of methanol, ethanol, n-propanol, or isopropanol under a pressure of less than 30 barr.

专利号:CN-116103257-A
优先权日:2023-03-11
标 题 :Reductive amination enzyme mutant and application thereof in synthesis of alkylated pyrrolidine chiral amine

专利号:CN-116103257-B
优先权日:2023-03-11
标题 :Reductive amination enzyme mutants and their application in the synthesis of alkylated pyrrolidine chiral amines