专利号:US-2025236633-A1 优先权日:2022-03-28 标 题:Synthesis of isomerically pure polyol-based phosphoramidites 发明人:BANASIK BRENT; DIAZ CORRAL JULIAN ANDRES; JACOBS AARON; JUD LUKAS; KUCHELMEISTER HANNES; NBAVI MELUD; PFAFFENEDER TONI; SIMONYIOVA SONA; TABONE JOHN C; THUER WILMA 权利人:ROCHE SEQUENCING SOLUTIONS INC 摘要:The present disclosure relates to a process for the regiochemically and enantiomerically controlled synthesis of phosphoramidite-containing monomers, and to intermediate products of this process. In some embodiments, the phosphoramidite-containing monomers or their precursors are regioisomerically and/or enantiomerically pure and may be polymerized into polymers or copolymers.
专利号:US-9273184-B1 优先权日:2009-12-24 标题:Synthesis of highly fluorinated amines for use in polymers and biomaterials 发明人:WILLIAMS TRAVIS J; BOZ EMINE 权利人:WILLIAMS TRAVIS J; BOZ EMINE; UNIV SOUTHERN CALIFORNIA 摘要:A method for forming a fluorinated compound includes a step of forming a sulfonate ester of a polyethylene glycol. The sulfonate ester is then reacted with a fluorinated diol in the presence of a base such that the polyethylene glycol is attached to one of the hydroxyl groups in the fluorinated diol. The other hydroxyl group in the fluorinated diol is reacted is converted into a leaving group and reacted with an number of nucleophiles. Complexes of the fluorinated compounds that as useful in Magnetic Resonance Imaging are also provided.
专利号:US-7932311-B2 优先权日:2005-12-23 标题 :Synthesis of particles in dendritic structures 发明人:AYMONIER CYRIL; CANSELL FRANCOIS; MECKING STEFAN; MOISAN SANDY; MARTINEZ VICTOR 权利人:CENTRE NAT RECH SCIENT 摘要:The invention relates to a method of preparing a particle-based composition, comprising: (i) bringing into contact a mixture comprising a dendritic structure and a metal compound precursor in a fluid, under temperature and pressure conditions such that the mixture is not soluble in the fluid; and (ii) chemically converting the metal compound precursor.
专利号:US-9175026-B2 优先权日:2011-03-23 标题:Synthesis of thioether containing trialkoxysilanes 发明人:GARRELL ROBIN L; TUCKER-SCHWARTZ ALEXANDER K 权利人:GARRELL ROBIN L; TUCKER-SCHWARTZ ALEXANDER K; UNIV CALIFORNIA 摘要:The invention relates to a radical-initiated thiol-ene or thiol-yne “clickâ€? reaction that provides a simple and efficient route to diverse trialkoxysilanes. Trialkoxysilanes made in this way are obtained in quantitative to near-quantitative yields with high purity without any or minimal purification. A wide range of functional groups is tolerated in this approach, and even complex alkenes click with the silane precursors. The modular nature of these radical-based thiol-ene or thiol-yne “clickâ€? reactions allows a wide variety of pendant groups to be coupled to silane compounds that can then be coupled to a wide variety surfaces in order to modify their material properties. Consequently, such radical initiated thiol-ene and thiol-yne reactions provide facile and efficient methods for preparing an enormous number of surface-active functional trialkoxysilanes.
专利号:US-6822121-B2 优先权日:2000-06-07 标题:Production process of cyclohexenyl ketones 发明人:WATANABE SHINYA; UJIHARA HIDEO; YAMAMOTO TAKESHI; HAGIWARA TOSHIMITSU 权利人:TAKASAGO PERFUMERY CO LTD 摘要:An economical process for producing (2- and/or 1-)cyclohexenyl methyl ketones which are intermediates for the synthesis of alpha- or beta-damascone. In the presence of a catalyst, a 3-cyclohexenyl methyl ketone represented by the following formula (1a):wherein, R1, R2 and R3 each independently represents a hydrogen atom or a methyl group and at least two of R1, R2 and R3 are methyl groups, is isomerized.
专利号:US-10787576-B2 优先权日:2015-04-30 标 题 :Method for the preparation of a coating comprising oligomeric alkynes 发明人:FRAUENRATH HOLGER; SCHRETTL STEPHEN; SCHULTE BJOERN; LETERRIER YVES 权利人:ECOLE POLYTECHNIQUE FED DE LAUSANNE EPFL EPFL TTO 摘要:The invention relates to a method for the preparation of a coating comprising at least one coating layer on a substrate, the method comprising the steps of a. providing monomers of the type R—(N) x -(L) m -(Câ•?C) n -(L′) o -(N′) y —R′, wherein R is a head moiety, R′ is a tail moiety, (C≡C) n is an oligoyne moiety, L and L′ are linker moieties, N and N′ independently are branched or unbranched optionally substituted C 1 -C 25 alkyl moieties optionally containing 1 to 5 heteroatoms, x, m, o, and y are independently 0 or 1, n is 4 to 12, and wherein the head moiety allows for an interaction with the surface of the substrate; b. bringing the monomers into contact with the substrate wherein the interaction of the head moieties of the monomers with the surface of the substrate induces at least a part of the monomers to align in a defined manner thereby forming a film on the surface and bringing the oligoyne moieties of the monomers into close contact with each other; c. inducing a reaction between oligoyne moieties by providing an external stimulus so as to at least partially cross-link the aligned monomers, thereby forming a coating layer on the substrate. The invention further relates to a coating obtainable according to the method of the invention, the use of a coating obtainable according to the method of the invention, a substrate comprising a coating obtainable according to the invention and the use of solid substrate. The invention further relates to a method for the synthesis ofthe monomers according to the invention.
1: Brown A, Patel S, Ward C, Lorenz A, Ortiz M, DuRoss A, Wieghardt F, Esch A, Otten EG, Heiser LM, Korolchuk VI, Sun C, Sarkar S, Sahay G. PEG-lipid micelles enable cholesterol efflux in Niemann-Pick Type C1 disease-based lysosomal storage disorder. Sci Rep. 2016 Aug 30;6:31750. doi: 10.1038/srep31750. 2: Saifer MG, Williams LD, Sobczyk MA, Michaels SJ, Sherman MR. Selectivity of binding of PEGs and PEG-like oligomers to anti-PEG antibodies induced by methoxyPEG-proteins. Mol Immunol. 2014 Feb;57(2):236-46. doi: 10.1016/j.molimm.2013.07.014. Epub 2013 Nov 5. doi: 10.1517/17425247.2012.720969. Epub 2012 Aug 30.
合成参考文献
摘要:International Journal of Toxicology 31(Suppl. 2):169-244, 2012