专利号:US-5861532-A 优先权日:1997-03-04 标 题:Solid-phase synthesis of N-alkyl amides 发明人:BROWN EDWARD G; NUSS JOHN M 权利人:CHIRON CORP 摘要:Methods for solid phase synthesis of N-alkyl amides comprise reductive amination of carbonyl compounds using a reducing agent and an amine-containing linker bound to a solid support. The methods afford high yields of linker-bound, monoalkylated amines, and subsequent coupling with acid derivatives provide derivatized N-substituted amides in excellent yields after cleavage from the solid-phase. Compositions useful in solid phase synthesis are also described.
专利号:WO-2012173504-A2 优先权日:2011-06-15 标 题 :Method for synthesis of the substituted azetidinones and intermediates for their synthesis
专利号:US-2002173632-A1 优先权日:2001-01-22 标 题 :Synthesis of furanose and aminofuranose compounds
专利号:US-5196606-A 优先权日:1990-02-06 标题 :Aromatic tertiary amines, enamines, deoxybenzoins and benzils 发明人:HAY ALLAN S; PAVENTI MARTINO 权利人:HAY ALLAN S; PAVENTI MARTINO 摘要:A novel synthesis of aromatic tertiary amines involves reacting an aromatic anil and an aromatic ether in a molar ratio of 1:1; adjusting the ratio to 2:1 produces novel enamines and by employing a two step process for enamine production, various unsymmetrically substituted enamines can be obtained which are readily hydrolyzed to corresponding deoxybenzoins which in turn are readily oxidized to benzils, the aromatic tertiary amines may be used to produce charge transport layers in xerography, while the benzils may be used to produce a variety of desired polymers.
专利号:US-5117062-A 优先权日:1990-02-06 标 题 :Aromatic tertiary amines, enamines, deoxybenzoins and benzils 发明人:HAY ALLAN S; PAVENTI MARTINO 权利人:HAY ALLAN S; PAVENTI MARTINO 摘要:A novel synthesis of aromatic tertiary amines involves reacting an aromatic anil and an aromatic ether in a molar ratio of 1:1; adjusting the ratio to 2:1 produces novel enamines and by employing a two step process for enamine production, various unsymmetrically substituted enamines can be obtained which are readily hydrolyzed to corresponding deoxybenzoins which in turn are readily oxidized to benzils, the aromatic tertiary amines may be used to produce charge transport layers in xerography, while the benzils may be used to produce a variety of desired polymers.
专利号:US-6416861-B1 优先权日:1999-02-16 标题 :Organosilicon compounds and uses thereof 发明人:LEE YOUNGHEE; SILVERMAN RICHARD B 权利人:UNIV NORTHWESTERN 摘要:A compound of the formula: n and a resin-bound compound of the formula: n and their use in combinatorial chemistry and in the synthesis of compounds comprising at least one aromatic moiety is described, where R 1 , R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , L 1 , P, Ar 1 , and X are as herein defined.
[参考文献]: Michael J Hearn, Et Al. Preparation And Antitubercular Activities In Vitro And In Vivo Of Novel Schiff Bases Of Isoniazid. Eur J Med Chem. 2009 Oct;44(10):4169-78.
合成参考文献
摘要:Kwiecień, H., Science of Synthesis Knowledge Updates, (2014) 4, 202. 摘要:Atodiresei, I.; Rueping, M., Science of Synthesis Knowledge Updates, (2017) 1, 384.